Repository Penicillin Therapy of Yaws in the Haitian Peasant

Rein, Charles R.; Kitchen, Delmas K.; Petrus, Edouard

doi:10.1038/jid.1950.32

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…Following treatment of primary or secondary yaws, skin lesions usually resolve within 2–4 weeks and bone pain may begin to resolve in as little as 48 hours. 41 …”

Section: Clinical Featuresmentioning

confidence: 99%

Endemic treponemal diseases

Marks

Solomon

Mabey

2014

Transactions of the Royal Society of Tropical Medicine and Hygiene

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The endemic treponemal diseases, consisting of yaws, bejel (endemic syphilis) and pinta, are non-venereal infections closely related to syphilis, and are recognized by WHO as neglected tropical diseases (NTDs). Despite previous worldwide eradication efforts the prevalence of yaws has rebounded in recent years and the disease is now a major public health problem in 14 countries. Adequate data on the epidemiology of bejel and pinta is lacking. Each disease is restricted to a specific ecological niche but all predominantly affect poor, rural communities. As with venereal syphilis, the clinical manifestations of the endemic treponemal diseases are variable and can be broken down in to early stage and late stage disease. Current diagnostic techniques are unable to distinguish the different causative species but newer molecular techniques are now making this possible. Penicillin has long been considered the mainstay of treatment for the endemic treponemal diseases but the recent discovery that azithromycin is effective in the treatment of yaws has renewed interest in these most neglected of the NTDs, and raised hopes that global eradication may finally be possible.

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“…Following treatment of primary or secondary yaws, skin lesions usually resolve within 2–4 weeks and bone pain may begin to resolve in as little as 48 hours. 41 …”

Section: Clinical Featuresmentioning

confidence: 99%

Endemic treponemal diseases

Marks

Solomon

Mabey

2014

Transactions of the Royal Society of Tropical Medicine and Hygiene

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“…Failure of targeted treatment of people with active yaws and their contacts with penicillin by WHO and UNICEF in the 1940s and 1950s was thought to be due to continued untreated asymptomatic infection because of the tendency for untreated latent yaws to relapse early. 26,27 Treatment of latent disease is, therefore, a crucial part of eradication efforts. The availability of a well tolerated oral agent prompted WHO to develop an eradication strategy that involved treatment of all members of yaws-endemic communities, irrespective of clinical status.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study

Mitjà

González-Beiras

Godornes

et al. 2017

The Lancet Global Health

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“…Osteoperiostitis, affecting the fingers (resulting in dactylitis) or long bones (forearm, fibula, tibula) is the most common bony manifestation of secondary yaws. Following treatment of early yaws (primary or secondary) skin lesions usually resolve within 2–4 weeks and bone pain may start to resolve in as little as 48 h [ 23 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Early studies conducted in Haiti demonstrated that penicillin-based treatments were highly efficacious in the treatment of yaws [ 23 ] and penicillin-based therapy was subsequently adopted as the standard of care worldwide for all endemic treponematoses [ 14 ]. Different penicillin-based regimes are effective for the treatment of yaws, but long-acting intramuscular benzathine benzylpenicillin was the most commonly used regimen.…”

Section: Penicillin-based Treatmentmentioning

confidence: 99%

Advances in the Treatment of Yaws

Marks

2018

TropicalMed

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Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Recently, oral azithromycin has been shown to be an effective treatment for yaws, facilitating renewed yaws eradication efforts. Resistance to azithromycin is an emerging threat and close surveillance will be required as yaws eradication efforts are scaled up globally.

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Repository Penicillin Therapy of Yaws in the Haitian Peasant

Cited by 11 publications

References 13 publications

Endemic treponemal diseases

Endemic treponemal diseases

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study

Advances in the Treatment of Yaws

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