Our aim is to establish relations between Drazin inverses of the pesudo-block matrix (P, Q, R, S ) and the block matrix P R S Q , where R 2 = S 2 = 0. Based on the relations, we give representations for Drazin inverses of the sum P + Q + R + S under weaker restrictions. As its applications, several expressions for Drazin inverses of a 2 × 2 block matrix are presented under some assumptions. Our results generalize several results in the literature.