In Europe, measuring instruments under legal control are responsible for an annual turnover of 500 billion Euros and contribute a significant part to the economy including establishing trust between all stakeholders. In this article, a secure cloud reference architecture for measuring instruments is presented, addressing both requirements and roles in the Legal Metrology framework. With the introduction of Cloud Computing in Legal Metrology, a new role of a Cloud Service Provider has to be established. The general approach of the reference architecture shall be evaluated to determine if Cloud Computing can be integrated into the legal framework. In a bottom‐up approach, each layer of the cloud is addressed and carefully tested against the essential requirements for Legal Metrology. Splitting a well‐contained measuring instrument into a distributed measuring system creates new challenges guaranteeing security and integrity of the measurements. Addressing these problems, technologies such as fully homomorphic encryption are evaluated, improved, and implemented to enable calculations on encrypted measurements. In addition, a secure communication protocol for encrypted data is presented to address the demand of integrity of encrypted measurements throughout their lifecycle. Lastly, a continuous monitoring approach is presented to detect anomalies and to classify the system behavior depending on their severity and impact into three categories: green, yellow, and red.