Representation of hedonics and quality of taste stimuli in the parabrachial nucleus of the rat

Yamamoto, Takashi; Shimura, Tsuyoshi; Sakai, Nobuyuki; N, Ozaki

doi:10.1016/0031-9384(94)90366-2

Cited by 129 publications

(131 citation statements)

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“…The PBN is suggested to be involved in the acquisition of CTA (14,22,34). The present results showed that the loss of Fosmediated signaling in the PBN during the conditioning weakened the acquisition of CTA, resulting in the attenuated retention of CTA.…”

Section: Discussionmentioning

confidence: 47%

“…Neurons in the PBN, the second-order gustatory relay station in the rat central gustatory pathway, are known to induce c-fos expression in response to gustatory and visceral stimuli (16,22,23,31,32). The present study showed that PBN neuronal responses at least at the early phase (15 s) of taste stimulation were not altered after the acute blockage of c-fos mRNA translation (Fos protein synthesis) by AS-ODN within the PBN, and that the same treatment did not affect the expression of LiCl-induced Fos-li-positive cells in the CeA.…”

Section: Discussionmentioning

confidence: 99%

“…In CTA, the patterns of the c-fos gene expression in the brainstem nuclei, including the parabrachial nucleus (PBN), amygdala (AMY), and insular cortex (IC) induced by a taste CS and͞or a visceral US have been extensively reported (16)(17)(18)(19)(20)(21)(22)(23). However, the functional significance of the up-regulation of c-fos gene expression and Fos protein synthesis in these brain sites remains unclear.…”

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confidence: 99%

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Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Yasoshima

Sako

Senba

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Yasoshima

Sako

Senba

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…Training involving peripheral stimulation usually modifies the relative representation in primate auditory cortex (5) or in somatosensory cortices of both humans (23), nonhuman primates (24), and rodents (4,25). However, unlike the above cited studies, in our experiments maps rearrangement is caused not by a modification in the stimulus-receptor interaction at the periphery (the bottom-up inputs) but rather by viscero-gustatory interaction that might occur from top-down modulations in early brainstem relays, such as the nucleus of solitary tract (26,27), the parabrachial nucleus (28,29), or CTA-related forebrain centers, such as basolateral amygdala (10) and primary GC (11,12).…”

Section: Discussionmentioning

confidence: 49%

“…In a series of studies using c-FLI expression, Yamamoto et al (29) conditioned rats to saccharin aversion and individuated subnuclei in the parabrachial nucleus responding only to the hedonic value of the stimulus, with other regions responding to the pure taste modality. Despite the evidence that hedonic value might be determined in the brainstem, altogether the imaging and electrophysiological approaches demonstrate that the GC distinguishes between positive and negative hedonics, although it does not seem to possess an area exclusively dedicated to this processing.…”

Section: Discussionmentioning

confidence: 99%

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Accolla

Carleton²

2008

Proc. Natl. Acad. Sci. U.S.A.

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Primary sensory cortices are remarkably organized in spatial maps according to specific sensory features of the stimuli. These cortical maps can undergo plastic rearrangements after changes in afferent (''bottom-up'') sensory inputs such as peripheral lesions or passive sensory experience. However, much less is known about the influence of ''top-down'' factors on cortical plasticity. Here, we studied the effect of a visceral malaise on taste representations in the gustatory cortex (GC). Using in vivo optical imaging, we showed that inducing conditioned taste aversion (CTA) to a sweet and pleasant stimulus induced plastic rearrangement of its cortical representation, becoming more similar to a bitter and unpleasant taste representation. Using a behavior task, we showed that changes in hedonic perception are directly related to the maps plasticity in the GC. Indeed imaging the animals after CTA extinction indicated that sweet and bitter representations were dissimilar. In conclusion, we showed that an internal state of malaise induces plastic reshaping in the GC associated to behavioral shift of the stimulus hedonic value. We propose that the GC not only encodes taste modality, intensity, and memory but extends its integrative properties to process also the stimulus hedonic value.chemical senses ͉ map plasticity ͉ taste coding

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Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

et al. 1997

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We have analysed in briefly anaesthetised rats (1% halothane for 18 minutes) the effects of innocuous and noxious heat, applied to the hindpaw, on evoked c-Fos immunoreactivity at the levels of the parabrachial area (PB), spinal cord, and nucleus of the solitary tract (NTS). After anaesthesia recovery, animals were left to move freely for 2 hours. At the spinal level, c-Fos was expressed primarily in the ipsilateral superficial laminae, increasing with the applied temperatures in a dependent manner in the noxious range (correlation coefficient r = 0.954, n = 20). At the NTS level, no noxiously evoked c-Fos expression was observed. At the PB level, c-Fos was expressed preferentially contralaterally, increasing with the applied temperatures in a dependent manner in the noxious range (r = 0.971, n = 25). The maximum expression was observed in the outer portion of the external lateral, the lateral crescent, and the superior lateral subnuclei around the pontomesencephalic junction. This was congruent with the densest supraspinal projection of lamina I neurones of the dorsal horn. Labelling in the PB area was highly correlated (r = 0.936, n = 20) with labelling in the superficial laminae. We conclude that, under our experimental procedures, noxious heat-induced c-Fos expression at the PB level depends on the intensity of the noxious stimulation. These data further support the relevance of the recently described spino-PB pain pathway. Because of their location, the Fos-immunoreactive neurones observed in the pontine and the mesencephalic divisions of the PB area were likely PB-amygdaloid and PB-hypothalamic nociceptive neurones, respectively.

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Representation of hedonics and quality of taste stimuli in the parabrachial nucleus of the rat

Cited by 129 publications

References 14 publications

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

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