Compliance of studies with the priority directions of scientific development in the country is an important factor in realizing the research potential of scholars. The article analyzes the directions of scientific research held in the Ural Branch of the Russian Academy of Sciences (UB RAS) organizations and their interdisciplinary interactions in the context of RF priority areas of science and technology development. The research bases on the content analysis of strategic documents at the national and federal levels, programs for the development of the scientific sphere (Forecast of scientific and technological development of the Russian Federation for the period up to 2030) and the analysis of scientific activities of the institutes of the Ural Branch based on scientometric data (Scopus).It is revealed that the leading research directions of Ural scientists enter scientific fields, which, due to the Forecast, are promising for science and technology development. These areas include “Materials Science”, “Biochemistry and Molecular Biology”, “Medicine”, “Immunology and Microbiology”, “Pharmacology, Toxicology, Pharmacy”, “Energy”.Fundamental scientific fields, not dir ectly reflected in the key areas of science and technology development, contribute to their development through the established interdisciplinary ties. They include “Physics and Astronomy”, “Chemistry”, “Engineering”, “Mathematics” and others. Researches on interdisciplinary problems have greater potential for international cooperation.