Representation of the tongue in the cerebellar nuclei of the monkey

Aldes, Leonard D.; Bowman, James P.

doi:10.1016/0014-4886(79)90015-3

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…The INC, a prominent component of the central midbrain, is of particular interest because it is a site of convergence for extrapyramidal inputs from the cerebellar [Chan-Palay, 1977;Faull and Carmen, 1978;Kalil, 19811 and vestibular [Tarlov, 1969, 19701 nuclei and, perhaps, the cerebral cortex [Leichnitz, 1980;Saint-Cyr and Courville, 19801. Recent studies in the rhesus monkey have shown that the cerebellar nuclei exert a profound influence on the tongue musculature [Aldes and Bowman, 1979;Bowman and Aldes, 19801. The INC-NRo projection may serve as part of the substrate by which the cerebellum affects orolingual motor behavior.…”

Section: Discussionmentioning

confidence: 99%

Does the interstitial nucleus of Cajal project to the hypoglossal nucleus in the rat?

Aldes

Boone

1984

J of Neuroscience Research

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The present study sought to determine whether or not the hypoglossal nucleus receives direct afferent projections from the interstitial nucleus of Cajal. Results from anterograde and retrograde labeling experiments in the rat indicated that while projections from the interstitial nucleus of Cajal do not terminate within the hypoglossal nucleus, they do so among a small group of neurons located ventrolateral to the hypoglossal nucleus, the nucleus of Roller. These findings are discussed in relation to orolingual motor behavior.

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Section: Discussionmentioning

confidence: 99%

Does the interstitial nucleus of Cajal project to the hypoglossal nucleus in the rat?

Aldes

Boone

1984

J of Neuroscience Research

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“…In primates, stimulation of the fastigial nucleus moves the tongue predominantly in the ventraldorsal axis, while stimulation of the dentate nucleus moves it mainly in the lateral-medial axis (7). Notably, tongue muscles are most readily activated through stimulation of the fastigial nucleus (as compared to the other cerebellar nuclei) (8), suggesting that the P-cells that are located in the vermis play a prominent role in control of the tongue. Unfortunately, there are no published reports of P-cell activity in the vermis during targeted tongue movements in any species, but more is known regarding activity of P-cells in Crus I and Crus II regions (in rodents).…”

Section: Introductionmentioning

confidence: 99%

Control of tongue movements by the Purkinje cells of the cerebellum

Hage,

Fakharian,

Shoup

et al. 2024

Preprint

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To quantify the cerebellum's contributions to control of the tongue, we trained head-fixed marmosets to make dexterous movements, harvesting food from small tubes that were placed orthogonal to the mouth. We identified the lingual regions in lobule VI of the vermis and recorded from hundreds of Purkinje cells (P-cells), each in sessions where the subject produced thousands of licks. Most movements aimed for one of the small tubes, while other movements groomed the mouth area. To quantify contributions of a P-cell to control of the tongue, we relied on the fact that in a small fraction of the licks, the input from the inferior olive produced a complex spike (CS), which then briefly but completely silenced the P-cell. When the movements were targeting a tube, the CS rates increased during protraction for both ipsilateral and contralateral targets, thus identifying the preferred axis of motion in the olivary input, termed CS-on. However, for grooming movements this modulation was absent. We compared the tongue's trajectory in the targeted movement that had experienced the CS with temporally adjacent targeted licks that had not. When the SS suppression occurred during protraction, the tongue exhibited hypermetria, and when the suppression took place during retraction, the tongue exhibited slowing. These effects amplified when two P-cells were simultaneously suppressed. Therefore, CS-induced suppression of P-cells in the lingual vermis disrupted the forces that would normally decelerate the tongue as it approached the target, demonstrating a specialization in stopping the movement. Because the CS-on direction tended to align with the direction of downstream forces produced during P-cell suppression, this suggests that for targeted licks, the olivary input defined an axis of control for the P-cells.

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