Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer

Shozu, Kanto; Kaneko, Syuzo; Shinkai, Norio; Dozen, Ai; Kosuge, Hirofumi; Nakakido, Makoto; Machino, Hidenori; Takasawa, Ken; Asada, Ken; Komatsu, Masaaki; Tsumoto, Kouhei; Ohnuma, Shin-ichi; Hamamoto, Ryuji

doi:10.1186/s13148-022-01370-z

Cited by 7 publications

(11 citation statements)

References 67 publications

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“…The protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been investigated in the pathogenesis of Hutchinson-Gilford progeria, psoriatic and rheumatoid arthritis, bladder cancer and respiratory tract infections [50]. ADORA2B gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily.…”

Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

Preprint

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Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell disease (SCD) affecting 6-10% of adult SCD patients. Various mechanisms and theories have been evaluated to explain the pathophysiology of the disease. However, questions remain, particularly regarding the clinical heterogeneity of the disease in terms of symptoms, complications, and survival. Beyond the classical mechanisms that have been thoroughly investigated and include hemolysis, nitric oxide availability, endothelial disorders, thrombosis, and left heart failure, attention is focused nowadays on the potential role of the genes involved in such processes. Potential candidate genes are investigated through next-generation sequencing, with the TGF-β pathway being the initial target. This field of research may also provide novel targets for pharmacologic agents in the future as is already the case with idiopathic PH. The collection and processing of data and samples from multiple centers can yield safe results that will allow a better understanding of SCD-related PH as a part of the disease’s clinical spectrum. The following review attempts to capture the most recent findings of studies on gene polymorphisms that have been associated with PH in SCD patients.

show abstract

Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been investigated in the pathogenesis of Hutchinson-Gilford progeria, psoriatic and rheumatoid arthritis, bladder cancer, and respiratory tract infections [61]. The ADORA2B gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily.…”

Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

IJMS

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell disease (SCD), affecting 6–10% of adult SCD patients. Various mechanisms and theories have been evaluated to explain the pathophysiology of this disease. However, questions remain, particularly regarding the clinical heterogeneity of the disease in terms of symptoms, complications, and survival. Beyond the classical mechanisms that have been thoroughly investigated and include hemolysis, nitric oxide availability, endothelial disorders, thrombosis, and left heart failure, attention is currently focused on the potential role of genes involved in such processes. Potential candidate genes are investigated through next-generation sequencing, with the transforming growth factor-beta (TGF-β) pathway being the initial target. This field of research may also provide novel targets for pharmacologic agents in the future, as is already the case with idiopathic PH. The collection and processing of data and samples from multiple centers can yield reliable results that will allow a better understanding of SCD-related PH as a part of the disease’s clinical spectrum. This review attempts to capture the most recent findings of studies on gene polymorphisms that have been associated with PH in SCD patients.

show abstract

“…Human embryonic kidney cells expressing SV40 large T antigen 293T and the ovarian cancer cell line ES2 were cultured as described previously [22,23]. The immortalized human ovarian endometriotic epithelial cell line HMOsisEC10 was grown in an F-medium supplemented with 5% fetal bovine serum (FBS) (10270106, Thermo-Fisher Scientific, Waltham, MA, USA) and 1% antibiotic-antimycotic (100×; 15240-062, Thermo-Fisher Scientific, Waltham, MA, USA) [24].…”

Section: Cell Culturementioning

confidence: 99%

Tumor Suppressive Role of the PRELP Gene in Ovarian Clear Cell Carcinoma

Dozen

Shozu

Shinkai

et al. 2022

JPM

Self Cite

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Ovarian clear cell carcinoma (OCCC) has a poor prognosis, and its therapeutic strategy has not been established. PRELP is a leucine-rich repeat protein in the extracellular matrix of connective tissues. Although PRELP anchors the basement membrane to the connective tissue and is absent in most epithelial cancers, much remains unknown regarding its function as a regulator of ligand-mediated signaling pathways. Here, we obtained sets of differentially expressed genes by PRELP expression using OCCC cell lines. We found that more than 1000 genes were significantly altered by PRELP expression, particularly affecting the expression of a group of genes involved in the PI3K-AKT signaling pathway. Furthermore, we revealed the loss of active histone marks on the loci of the PRELP gene in patients with OCCC and how its forced expression inhibited cell proliferation. These findings suggest that PRELP is not only a molecule anchored in connective tissues but is also a signaling molecule acting in a tumor-suppressive manner. It can serve as the basis for early detection and novel therapeutic approaches for OCCC toward precision medicine.

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Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer

Cited by 7 publications

References 67 publications

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Tumor Suppressive Role of the PRELP Gene in Ovarian Clear Cell Carcinoma

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