Reprint of: Effects of the antidepressant venlafaxine on fish brain serotonin and predation behavior

Bisesi, Joseph H.; Bridges, William C.; Klaine, Stephen J.

doi:10.1016/j.aquatox.2014.02.015

Cited by 37 publications

(14 citation statements)

References 51 publications

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“…Other reports have also found abnormal effects by the drug, for example, alterations in the rat prenatal development during pregnancy (Da Silva et al, 1999), or birth defects related with periconceptional use of the antidepressant (Polen et al, 2013). Moreover, ecological damage related with venlafaxine aquatic contamination has also been reported, as shown by alterations in the immune system of the blue mussel (Lacaze et al, 2015), boost of locomotion as a prelude to foot detachment in the oyster drill (Urosalpinx cinerea) and the star snail (Lithopoma americanum) (Fong et al, 2015), decrease in the brain serotonin level and in predation behavior in the striped bass (Bisesi et al, 2014), and disruption of brain monoamine levels and neuroendocrine responses in rainbow trout (Melnyk-Lamont et al, 2014). Also, in a transgenerational study in Daphnia magna (Minguez et al, 2015), authors found that venlafaxine exposure decreased the offspring number of F0 daphnids and caused drug tolerance in the F1 generation.…”

Section: Acute Genotoxic Assaymentioning

confidence: 99%

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

et al. 2024

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The present research was made to determine the micronuclei and cytotoxic capacity of the antidepressant venlafaxine in an in vivo acute and subchronic assays in mouse. In the first study, we administered once 5, 50, and 250 mg/kg of the drug, and included a negative and a daunorubicin treated group. Observations were daily made during four days. The subchronic assay lasted 5 weeks with daily administration of venlafaxine (1, 5, and 10 mg/kg) plus a negative and an imipramine administered groups. Observations were made each week. In the first assay results showed no micronucleated polychromatic erythrocytes (MNPE) increase, except with the high dose at 72 h. The strongest cytotoxic effect was found with 250 mg/kg at 72 h (a 51% cytotoxic effect in comparison with the mean control level). In the subchronic assay no MNPE increase was found; however, with the highest dose a significant increase of micronucleated normochromatic erythrocytes was observed in the last three weeks (a mean of 51% respect to the mean control value). A cytotoxic effect with the two high doses in the last two weeks was observed (a polychromatic erythrocyte mean decrease of 52% respect to the mean control value). Results suggest caution with venlafaxine.

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Section: Acute Genotoxic Assaymentioning

confidence: 99%

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

et al. 2024

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“…Similarly, venlafaxine is a widely prescribed antidepressant that affects the brain serotonin levels of fishes. As this drug has been 14 20 poorly removed in conventional WWTP, advanced treatments such as ozonization are being studied (Bisesi et al, 2014;Li et al, 2015;Rúa-Gómez and Püttmann, 2013).…”

Section: Total Drugs Removalmentioning

confidence: 99%

A comparison between biostimulation and bioaugmentation in a solid treatment of anaerobic sludge: Drug content and microbial evaluation

et al. 2018

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Emerging pollutants can reach the environment through the sludge of Wastewater Treatment Plants. In this work, the use of Trametes versicolor in biopiles at lab-scale was studied, evaluating its capacity to remove the most hydrophobic Pharmaceuticals and assessing the evolution of the biopiles microbial communities. The total removal of drugs at real concentrations from sewage sludge was assessed for non-inoculated and fungal inoculated biopiles, testing if the re-inoculation of the biopiles after 22 days of treatment would improve the removal yields. It was found that 2 out of the 15 initially detected pharmaceuticals were totally degraded after 22 days, and re-inoculated fungal biopiles achieved higher removal rates than non-re-inoculated fungal biopiles for single compounds and for all the drugs simultaneously: 66.45% and 49.18% re-inoculated and non-re-inoculated biopiles, respectively. Finally, the study of the bacterial and fungal communities revealed that fungal inoculated and non-inoculated biopiles evolved to similar communities adapted to the presence of those drugs.

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“…Some of its adverse effects have already been studied and highlighted in non-target aquatic organisms. The following disruptions caused by VLF exposure have been reported in fish species: impairment of embryo production and larval development, alterations in behavior, circadian rhythms, and liver metabolism [ 10 , 11 , 12 ]. At the molecular level, antidepressants modulate neurotransmitters in aquatic organisms [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

et al. 2022

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There is growing evidence of the presence of pharmaceuticals in natural waters and their accumulation in aquatic organisms. While their mode of action on non-target organisms is still not clearly understood, their effects warrant assessment. The present study assessed the metabolome of the Mediterranean mussel (Mytilus galloprovincialis) exposed to a 10 µg/L nominal concentration of the antidepressant venlafaxine (VLF) at 3 time-points (1, 3, and 7 days). Over the exposure period, we observed up- or down-modulations of 113 metabolites, belonging to several metabolisms, e.g., amino acids (phenylalanine, tyrosine, tryptophan, etc.), purine and pyrimidine metabolisms (adenosine, cyclic AMP, thymidine, etc.), and several other metabolites involved in diverse functions. Serotonin showed the same time-course modulation pattern in both male and female mussels, which was consistent with its mode of action in humans, i.e., after a slight decrease on the first day of exposure, its levels increased at day 7 in exposed mussels. We found that the modulation pattern of impacted metabolites was not constant over time and it was gender-specific, as male and female mussels responded differently to VLF exposure.

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Reprint of: Effects of the antidepressant venlafaxine on fish brain serotonin and predation behavior

Cited by 37 publications

References 51 publications

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

A comparison between biostimulation and bioaugmentation in a solid treatment of anaerobic sludge: Drug content and microbial evaluation

Early Biological Modulations Resulting from 1-Week Venlafaxine Exposure of Marine Mussels Mytilus galloprovincialis Determined by a Metabolomic Approach

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