Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis

Gaffin, Jonathan M.; Kanchongkittiphon, Watcharoot; Phipatanakul, Wanda

doi:10.1016/j.intimp.2014.09.028

Cited by 9 publications

(5 citation statements)

References 195 publications

(211 reference statements)

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“…It is possible that this level was not exceeded in most of the women in our ETS exposed group. It has been hypothesized that the influence of ETS on the neonate observed in some studies could be due to the volatile organic compounds present in sidestream smoke [30] that may affect development of the fetus. This effect may depend on the conditions of the indoor environment and on climate.…”

Section: Discussionmentioning

confidence: 99%

Environmental tobacco smoke exposure during pregnancy affects complications and birth outcomes in women with and without asthma

Fazel

Kundi

Kazemzadeh

et al. 2020

BMC Pregnancy Childbirth

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Background: It is known that environmental tobacco smoke (ETS) has adverse effects on pregnancy and birth outcomes. We aimed to assess the impact of ETS in pregnant women with and without asthma. Methods: A cohort study was conducted from August 2014 to June 2015 enrolling 1603 pregnant women during their 2nd trimester. Data on tobacco exposure were collected at first visit and women were followed through pregnancy till postpartum. Results: Of the 1603 women, 231 reported passive smoking, 223 non-asthmatics and 8 asthmatics. Women exposed to ETS during pregnancy were more likely to have an infant admitted to the pediatric ward (10.8% vs. 6.5%, p = 0.026) and to have low one-and five-minute Apgar scores (1 min: 6.1% vs. 2.6%, p = 0.011; 5 min: 2.2% vs. 0.7%, p = 0.039). Complications of pregnancy were also elevated in women exposed to ETS (53.7% vs. 42.3%, p = 0.002). Asthma had no additional effect beyond the impact of ETS except for cesarean sections that were more frequent in women with asthma exposed to ETS. Conclusions: Due to the small number of women with asthma exposed to ETS, combined effects of asthma and ETS were only found for cesarean sections. Still counseling of pregnant women about adverse effects of ETS should consider women's asthma as an additional reason to avoid ETS.

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Section: Discussionmentioning

confidence: 99%

Environmental tobacco smoke exposure during pregnancy affects complications and birth outcomes in women with and without asthma

Fazel

Kundi

Kazemzadeh

et al. 2020

BMC Pregnancy Childbirth

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“…Gaffin JM et al revealed that early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO2), ozone (O3), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children [12].…”

Section: Prevalancementioning

confidence: 99%

“…Although presence of pets (OR =2.70) and inadequate ventilation (OR =2.71) were independently associated with bronchial asthma in children of school going age. Multicentre study should be planned to identify modifiable risk factor India [12].…”

Section: Prevalancementioning

confidence: 99%

Asthma prevalence & risk factor in children: Indian Scenario

Gedam

2014

Int J Med Res Rev

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“…Nitrogen dioxide (

) is a gaseous pollutant found in both outdoor and indoor environments. It is emitted via automobile exhaust, fossil fuel combustion, and power plant operations, all of which compose the majority sources of outdoor exposures, whereas indoor exposures are commonly due to emissions from cooking gas, heating systems, and sites with increased occupational exposures such as garages and ferries ( Ezratty et al 2014 ; Gaffin et al 2014 ). Importantly, indoor air

pollution is likely more serious than outdoor pollution ( Ezratty et al 2014 ) with maximum concentrations indoors reaching peaks of

( WHO 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization

Yue

Yan

et al. 2017

Environ Health Perspect

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Background:Fetal stress has been proposed to be associated with diseases in both children and adults. Epidemiological studies suggest that maternal exposure to nitrogen dioxide (NO2) contributes to increased morbidity and mortality of offspring with allergic asthma later in life.Objectives:We aimed to test whether maternal NO2 exposure causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and whether this exposure enhances the likelihood of developing allergic asthma or the intensity of developed allergic airway disease following postnatal allergic sensitization and challenge. In addition, if such consequences and enhancements occurred, we sought to determine the mechanism(s) of these responses.Methods:Pregnant BALB/c mice were exposed to either NO2 (2.5 ppm, 5 h/day) or air daily throughout the gestation period. Offspring were sacrificed on postnatal days (PNDs) 1, 7, 14, 21, and 42, and remaining offspring were sensitized by ovalbumin (OVA) injection followed by OVA aerosol challenge during postnatal wk 7–9. We analyzed the lung histopathology, inflammatory cell infiltration, airway hyper-responsiveness (AHR), immune responses, and gene methylation under different treatment conditions.Results:Maternal exposure to NO2 caused a striking increase in inflammatory cell infiltration and the release of type 2 cytokines in the lungs of offspring at PNDs 1 and 7; however, these alterations were reversed during postnatal development. Following OVA sensitization and challenge, the exposure enhanced the levels of allergic asthma-characterized OVA-immunoglobulin (Ig) E, AHR, and airway inflammation in adult offspring. Importantly, differentiation of T-helper (Th) 2 cells and demethylation of the interleukin-4 (IL4) gene occurred during the process.Conclusions:Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685

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Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis

Cited by 9 publications

References 195 publications

Environmental tobacco smoke exposure during pregnancy affects complications and birth outcomes in women with and without asthma

Environmental tobacco smoke exposure during pregnancy affects complications and birth outcomes in women with and without asthma

Asthma prevalence & risk factor in children: Indian Scenario

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization

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