Reprint of “Update of the reference and HBM values derived by the German Human Biomonitoring Commission”

Schulz, Christine; Wilhelm, Michael; Heudorf, U.; Kolossa-Gehring, Marike

doi:10.1016/j.ijheh.2012.01.003

Cited by 75 publications

(32 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few participants exceeded these values (Table 2). The P90 of the biomarker values is far below the guidance values; only the urinary cadmium P90 of mothers and children was within a factor 2 of the concentration below which no risk for adverse health effects is expected (Schulz et al 2012), and for mercury they are below a factor 3.…”

Section: Resultsmentioning

confidence: 92%

See 1 more Smart Citation

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Hond

Govarts

Willems

et al. 2015

Environ Health Perspect

Self Cite

171

View full text Add to dashboard Cite

BackgroundFor Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.ObjectivesWe developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.MethodsIn 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5–11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011–2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.ResultsBiomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.ConclusionsWe have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.CitationDen Hond E, Govarts E, Willems H, Smolders R, Casteleyn L, Kolossa-Gehring M, Schwedler G, Seiwert M, Fiddicke U, Castaño A, Esteban M, Angerer J, Koch HM, Schindler BK, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Koppen G, Katsonouri A, Hadjipanayis A, Krskova A, Maly M, Mørck TA, Rudnai P, Kozepesy S, Mulcahy M, Mannion R, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Gurzau AE, Lupsa IR, Halzlova K, Jajcaj M, Mazej D, Snoj Tratnik J, López A, Lopez E, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G. 2015. First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale. Environ Health Perspect 123:255–263; http://dx.doi.org/10.1289/ehp.1408616

show abstract

Section: Resultsmentioning

confidence: 92%

“…To put the results in a health risk context, we calculated the proportion of individuals with levels above health-based guidance values (Aylward et al 2009a, 2009b; Hays et al 2008; Schulz et al 2012; WHO 2004). …”

Section: Methodsmentioning

confidence: 99%

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Hond

Govarts

Willems

et al. 2015

Environ Health Perspect

Self Cite

171

View full text Add to dashboard Cite

show abstract

“…The median 1-OH-PYR level observed in the pregnant women's urine (0.35 μ g/g creatinine) was higher than that noted in the INMA cohort of nonsmoking pregnant women in Valencia (0.1 μ g/g creatinine) and postpartum nonsmoking women from Saudi Arabia (0.05 μ g/g creatinine) [5, 32]. The Human Biomonitoring Commission of the German Federal Environment Agency established 1-OH-PYR levels in urine of 0.3 μ g/g creatinine as the reference value for the nonsmoking general population aged between 3 and 69 years [33, 34]. In the present study, this reference value was much higher (1.0 μ g/g creatinine).…”

Section: Discussionmentioning

confidence: 99%

Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes: The Polish Mother and Child Cohort Study

Polańska

Dettbarn

Jurewicz

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

The aim of this study was to assess the impact of PAH exposure on various anthropometric measures of birth outcomes. The study population consisted of 210 nonsmoking pregnant women. Urine samples collected between 20th and 24th week of pregnancy were used for analysis of the following PAH metabolites: 1-, 2-, 3-, 4-, and 9-hydroxyphenanthrene (1-, 2-, 3-, 4-, and 9-OH-PHE), 1-hydroxypyrene (1-OH-PYR), 1,6 + 1,8-dihydroxypyrene (DI-OH-PYR), phenanthrene trans-1,2-dihydrodiol (PHE-1,2-diol), and phenanthrene trans-9,10-dihydrodiol (PHE-9,10-diol) by gas chromatography-mass spectrometry. Environmental tobacco smoke exposure (ETS) was assessed by cotinine level in saliva using a stable isotope dilution LC-ESI-MS/MS method. The mean PAH metabolite concentrations were in the range of 0.15 µg/g creatinine for 9-OH-PHE to 5.9 µg/g creatinine for PHE-9,10-diol. It was shown that none of the individual PAH exposure markers demonstrate a statistically significant influence on birth outcomes. Interestingly a statistically significant association was found between the sum of OH-PHE along with cotinine level and the cephalization index after adjusting for potential confounders (P = 0.04). This study provides evidence that combined exposure of pregnant women to common environmental pollutants such as PAH and ETS might adversely affect fetal development. Thus, reduction of human exposure to these mixtures of hazardous compounds would in particular result in substantial health benefits for newborns.

show abstract

“…The Human Biomonitoring Commission in Germany developed a health-based mercury exposure limit of 5 μg/g creatinine, below which no adverse health effects are expected (Schulz et al, 2007(Schulz et al, 2012. The maximum urinary mercury concentration measured in all samples collected in the Flin Flon area of 4.02 μg/g creatinine was below this reference value despite the occurrence of maximum soil mercury concentrations in West Flin Flon that exceeded the CCME soil guideline by a factor of 150.…”

Section: Urinary Inorganic Mercury Analysismentioning

confidence: 94%

“…A urinary reference value of 0.4 μg/L in children 3-14 years of age (without dental amalgam fillings) was derived from the 95% confidence interval for the 95th population percentile of The German Environmental Survey on Children (Schulz et al, 2012). The Human Biomonitoring Commission in Germany developed a health-based mercury exposure limit of 5 μg/g creatinine, below which no adverse health effects are expected (Schulz et al, 2007(Schulz et al, 2012.…”

Section: Urinary Inorganic Mercury Analysismentioning

confidence: 99%

The bioaccessibility of soil-based mercury as determined by physiological based extraction tests and human biomonitoring in children

Safruk

Berger

Jackson³

et al. 2015

Science of The Total Environment

View full text Add to dashboard Cite

Environmental contaminants associated with soil particles are generally less bioavailable than contaminants associated with other exposure media where chemicals are often found in more soluble forms. In vitro methods, such as Physiological Based Extraction Tests (PBET), can provide estimates of bioaccessibility for soil-based contaminants. The results of these tests can be used to predict exposure to contaminants from soil ingestion pathways within human health risk assessment (HHRA). In the current investigation, an HHRA was conducted to examine the risks associated with elevated concentrations of mercury in soils in the northern Canadian smelter community of Flin Flon, Manitoba. A PBET was completed for residential soils and indicated mean bioaccessibilities of 1.2% and 3.0% for total mercury using gastric phase and gastric+intestinal phase methodologies, respectively. However, as many regulators only allow for the consideration of in vitro results for lead and arsenic in the HHRA process, in vitro bioaccessibility results for mercury were not utilized in the current HHRA. Based on the need to assume 100% bioaccessibility for inorganic mercury in soil, results from the HHRA indicated the need for further assessment of exposure and risk. A biomonitoring study was undertaken for children between 2 and 15 years of age in the community to examine urinary inorganic mercury concentrations. Overall, 375 children provided valid urine samples for analysis. Approximately 50% of urine samples had concentrations of urinary inorganic mercury below the limit of detection (0.1 μg/L), with an average creatinine adjusted concentration of 0.11 μg/g. Despite high variability in mercury soil concentrations within sub-communities, soil concentrations did not appear to influence urinary mercury concentrations. The results of the current investigation indicate that mercury bioaccessibility in residential soils in the Flin Flon area was likely limited and that HHRA estimates would have been better approximated through inclusion of the in vitro study results.

show abstract

Reprint of “Update of the reference and HBM values derived by the German Human Biomonitoring Commission”

Cited by 75 publications

References 39 publications

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes: The Polish Mother and Child Cohort Study

The bioaccessibility of soil-based mercury as determined by physiological based extraction tests and human biomonitoring in children

Contact Info

Product

Resources

About