Reprint of “Vitamin D deficiency in pregnant women impairs regulatory T cell function”

Chary, Anchoju Vijayendra; Hemalatha, R.; Seshacharyulu, M.; Murali, M. Vasudeva; Jayaprakash, D.; Kumar, B. Dinesh

doi:10.1016/j.jsbmb.2015.01.026

Cited by 15 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of maternal vitamin D levels may influence perinatal and long-term outcomes through immune, antibacterial, and anti-inflammatory responses [ 99 , 129 ]. A recent study has found associations between vitamin D levels in maternal and cord blood and immune cell type proportions, as well as placental expression of immune system related genes [ 130 ]. Interestingly, vitamin D deficiency was also associated with downregulation of the expression of vitamin D receptor (VDR), FOXP3 (a transcription factor associated with Treg cells), and retinoic acid receptor (RAR).…”

Section: Nutritionmentioning

confidence: 99%

“…Interestingly, vitamin D deficiency was also associated with downregulation of the expression of vitamin D receptor (VDR), FOXP3 (a transcription factor associated with Treg cells), and retinoic acid receptor (RAR). It was also associated with upregulation of the expression of VDRB , complement receptors CD21 and CD23, and a Vitamin D regulatory enzyme ( CYP24A1 ) in the placenta [ 130 ].…”

Section: Nutritionmentioning

confidence: 99%

See 1 more Smart Citation

Epigenetic Biomarkers of Preterm Birth and Its Risk Factors

Knight

Smith

2016

Genes

View full text Add to dashboard Cite

A biomarker is a biological measure predictive of a normal or pathogenic process or response. Biomarkers are often useful for making clinical decisions and determining treatment course. One area where such biomarkers would be particularly useful is in identifying women at risk for preterm delivery and related pregnancy complications. Neonates born preterm have significant morbidity and mortality, both in the perinatal period and throughout the life course, and identifying women at risk of delivering preterm may allow for targeted interventions to prevent or delay preterm birth (PTB). In addition to identifying those at increased risk for preterm birth, biomarkers may be able to distinguish neonates at particular risk for future complications due to modifiable environmental factors, such as maternal smoking or alcohol use during pregnancy. Currently, there are no such biomarkers available, though candidate gene and epigenome-wide association studies have identified DNA methylation differences associated with PTB, its risk factors and its long-term outcomes. Further biomarker development is crucial to reducing the health burden associated with adverse intrauterine conditions and preterm birth, and the results of recent DNA methylation studies may advance that goal.

show abstract

Section: Nutritionmentioning

confidence: 99%

Section: Nutritionmentioning

confidence: 99%

Epigenetic Biomarkers of Preterm Birth and Its Risk Factors

Knight

Smith

2016

Genes

View full text Add to dashboard Cite

show abstract

“…Vitamin D has been shown to play an important role in both the innate and adaptive immune system. In vitro studies have demonstrated vitamin D to correlate with alterations of several cytokines such as IL-4, IL-5, IL-6, IL-10, IL-13, and interferon γ [ 1 – 3 ]. Hence, as a potent immune modulator, vitamin D was shown to be associated with childhood asthma and allergic diseases [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy

Liao

Lai

Tsai

et al. 2016

Mediators of Inflammation

View full text Add to dashboard Cite

Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r = 0.67, p < 0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.

show abstract

“… 149 One association study using data on 153 pregnant Indian women observed that altered maternal 25(OH)D could have a wide range of effects on regulatory T- and B-cells with IgE receptors. 150 In fact, the placental vitamin D-deficient women was characterized by a downregulation of the regulatory T-cell transcription factor FOX3 , VDR, retinoic acid receptor in comparison to control placenta. In contrast, CD23, CD21, and vitamin D-binding protein expression was upregulated by vitamin D. 150 An RCT following 225 infants examining the association of 25(OH)D in cord blood in relation to innate immune response has observed that increasing maternal vitamin D during pregnancy and early life will lessen the risk of allergy induced by cytokines.…”

Section: Discussionmentioning

confidence: 99%

“… 150 In fact, the placental vitamin D-deficient women was characterized by a downregulation of the regulatory T-cell transcription factor FOX3 , VDR, retinoic acid receptor in comparison to control placenta. In contrast, CD23, CD21, and vitamin D-binding protein expression was upregulated by vitamin D. 150 An RCT following 225 infants examining the association of 25(OH)D in cord blood in relation to innate immune response has observed that increasing maternal vitamin D during pregnancy and early life will lessen the risk of allergy induced by cytokines. 151 An observational study from Germany evaluating the association of season at birth, cord blood 25(OH)D, and the markers of allergy (IL-10 and IgE) reported that serum 25(OH)D was correlated with IL-10 levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective

Palaniswamy

Williams

Järvelin

et al. 2015

Nutr Metab Insights

View full text Add to dashboard Cite

Studies linking vitamin D and long-term metabolic health have generated much debate. Recommendations for the intake of vitamin D by the general public and by the health care professionals have been complicated by a number of inconsistencies in the literature. These caveats relate to the methodological approaches, differences in the populations (and the species) of study, and the definitions used for thresholds of vitamin D status. This review addresses current evidence available for assessing the potential programming of long-term metabolic health of offspring by maternal vitamin D status in pregnancy. It summarizes knowledge on the early origins of metabolic health and analyzes evidence for an association between the vitamin D status in pregnancy and maternal and fetal health status. In addition, we analyze the link between the regulation of inflammation and the vitamin D status in the general population to inform on the general mechanisms through which early vitamin D might affect the programming of long-term health. The evidence suggests an association between the vitamin D status in early life and the programming of long-term health. However, to the best of our knowledge, the current finding is insufficient to draw a final conclusion for evidence-based preventive actions. The data warrant replication in prospective studies and additional research substantiating the causal factors and pathways.

show abstract

Reprint of “Vitamin D deficiency in pregnant women impairs regulatory T cell function”

Cited by 15 publications

References 38 publications

Epigenetic Biomarkers of Preterm Birth and Its Risk Factors

Epigenetic Biomarkers of Preterm Birth and Its Risk Factors

Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy

Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective

Contact Info

Product

Resources

About