Reproducibilidad interobservador de un sistema de grado para el carcinoma de células renales tipo cromófobo

Pérez-Pedrosa, A.; Ortiz-Rey, J.A.; Lorenzo-Mahía, Y.; Iglesias-Rodríguez, B.; Peteiro-Cancelo, A.; González-Carreró, Joaquín

doi:10.1016/j.acuro.2012.04.005

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Third, only one pathologist reviewed all pathological features in our study. Perez-Pedrosa et al evaluated interobserver reproducibility of CTG, and found moderate discrete agreement between six participating observers [14]. Therefore, observer bias may have occurred in our study.…”

Section: Discussionmentioning

confidence: 47%

Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC

Lin

Chen

et al. 2019

Open Medicine

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AbstractBackgroundChromophobe renal cell carcinoma (chRCC) has a favorable prognosis. Due to irregular nuclei and nuclear pleomorphism, chRCC has a high Fuhrman nuclear grade (FNG). The chromophobe tumor grade (CTG) is a novel three-tier grading system that has been reported to be a better prognosticator than the traditional FNG. We compared the two nuclear grading systems in terms of patients’ clinical outcomes.Patients and MethodWe performed this retrospective chart review of all patients with chRCC from 2000 to 2017. All pathologic features and CTG and FNG results were re-evaluated.ResultEighteen patients’ records were reviewed with a mean follow-up of 70.6 months. The nuclear grading distribution was as follows: FNG 2, 56%; FNG 3, 39%; FNG 4, 5%; CTG 1, 78%; CTG 2, 17%; and CTG 3, 6%. Only one patient died. This patient had adrenal invasion, lung metastasis, sarcomatoid change and tumor necrosis, and the tumor was graded as FNG 4 and CTG 3. Overall survival was associated with both FNG and CTG.ConclusionChromophobe RCC was associated with a low rate of cancer-specific death and sarcomatoid differentiation. Both FNG and CTG were associated with overall survival.

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Section: Discussionmentioning

confidence: 47%

Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC

Lin

Chen

et al. 2019

Open Medicine

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“…Furman et al and Panel et al's tumor classification schemes have already been proposed for use in staging ChRCC over the past decades [ 4 , 5 ]. However, considering the ambiguity of the grading criteria and the lack of applicability to the characteristics of the nucleus of ChRCC, their prognostic value appears to have been overestimated [ 6 , 7 ]. In order to better standardize treatment and improve patient prognosis, it is critical to elucidate highly specific biomarkers and effective therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Weighted Gene Coexpression Network Analysis to Construct Competitive Endogenous RNA Network in Chromogenic Renal Cell Carcinoma

Chen

Gao

Zhang

et al. 2021

BioMed Research International

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Aim. This study is aimed at constructing the competing endogenous RNA (ceRNA) network in chromophobe renal cell carcinoma (ChRCC). Methods. Clinical and RNA sequence profiles of patients with ChRCC, including messenger RNAs (mRNAs), microRNAs (miRNAs), and long noncoding RNAs (lncRNAs), were obtained from The Cancer Genome Atlas (TCGA) database. “edgeR” and “clusterProfiler” packages were utilized to obtain the expression matrices of differential RNAs (DERNAs) and to conduct gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Weighted gene coexpression network analysis (WGCNA) was performed to screen the highly related RNAs, and miRcode, StarBase, miRTarBase, miRDB, and TargetScan datasets were used to predict the connections between them. Univariate and multivariate Cox proportional hazards regressions were performed in turn to elucidate prognosis-related mRNAs in order to construct the ceRNA regulatory network. Results. A total of 1628 DElncRNAs, 104 DEmiRNAs, and 2619 DEmRNAs were identified. WGCNA showed significant correlation in 1534 DElncRNAs, 98 DEmiRNAs, and 2543 DEmRNAs, which were related to ChRCC. Fourteen DEmiRNAs, 113 DElncRNAs, and 43 DEmRNAs were screened. Nine mRNAs (ALPL, ARHGAP29, CADM2, KIT, KLRD1, MYBL1, PSD3, SFRP1, and SLC7A11) significantly contributed to the overall survival (OS) of patients with ChRCC ( P < 0.05 ). Furthermore, two mRNAs (CADM2 and SFRP1) appeared to be independent risk factors for ChRCC. Conclusion. The findings revealed the molecular mechanism of ChRCC and potential therapeutic targets for the disease.

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Chromophobes Nierenzellkarzinom – Diagnostik und Prognostik

Erlmeier

2019

Pathologe

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Reproducibilidad interobservador de un sistema de grado para el carcinoma de células renales tipo cromófobo

Cited by 5 publications

References 8 publications

Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC

Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC

Weighted Gene Coexpression Network Analysis to Construct Competitive Endogenous RNA Network in Chromogenic Renal Cell Carcinoma

Chromophobes Nierenzellkarzinom – Diagnostik und Prognostik

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