Reproducibility and least significant differences of oral glucose tolerance test-derived parameters in a postmenopausal population without diabetes

Velde, F.P. Van de; Dierickx, Anneloor; Depypere, Herman; Delanghe, Joris; Kaufman, Jean M.; Lapauw, Bruno

doi:10.1016/j.diabet.2016.12.005

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…High false positive rates were observed in overweight and obese children and in postmenopausal women for prediabetes across different racial and ethnic groups [157,[163][164][165].…”

Section: Monophasic Vs Biphasic Shapementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

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Highlights A 1-hour plasma glucose (1-h PG) threshold >155 mg/dl (8.6 mmol/L) during an oral glucose tolerance test (OGTT) may be a suitable biomarker for identifying normal glucose tolerant (NGT) individuals at risk for future type 2 diabetes (T2D). A one-hour, non-fasting, 50g Glucose Challenge Test (GCT) performed during a routine health care visit has potential for practical screening of glucose disorders. The shape of the glucose curve reflects the cumulative effect of insulin sensitivity and response on glucose concentrations with prospective studies warranted to evaluate its prognostic utility. The continuous glucose monitor (CGM) has facilitated insight into the pathophysiology of prediabetes and phenotypes of T2D and holds promise for detecting glycemic disorders. Metabolomic profiling including amino acids, lipids, carbohydrates and other metabolites may be useful for early diagnosis of glycemic disorders. Non-classical markers for assessing glycemic disorders including fructosamine, glycated albumin, and 1,5-anhydroglucitol that evaluate shorter periods of glucose exposure than HbA1c have potential use as adjunctive tools.

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“…High false positive rates were observed in overweight and obese children and in postmenopausal women for prediabetes across different racial and ethnic groups [157,[163][164][165].…”

Section: Monophasic Vs Biphasic Shapementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

View full text Add to dashboard Cite

show abstract

“…Though the 2-hr OGTT is well-established for the diagnosis of T2DM, more recent analyses have highlighted poor intraindividual reproducibility and decreased reliability for prediabetes diagnosis in youth (28, 29) as well as reduced discriminatory ability in pregnant and post-menopausal women (30–32). Another study found differences in OGTT results were related to sex and/or variations in body size (tall/short) (33).…”

Section: Discussionmentioning

confidence: 99%

Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity

et al. 2018

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Background: During an oral glucose tolerance test (OGTT), morphological features of the glucose curve (monophasic curve, glucose peak >30mins and 1-hr glucose ≥155mg/dL) maybe associated with higher prediabetes risk, but their reproducibility and predictive ability in adolescents with obesity are unknown. Design/Methods: Nondiabetic adolescent girls with obesity underwent a multiple-sample OGTT at baseline (n=93), 6-weeks (n=83), and 1-year (n=72). Short-term reproducibility (baseline to 6-weeks) and the predictive ability for prediabetes (baseline to 1-year) for each feature were compared to standard fasting and 2-hr OGTT diagnostic criteria. Results: There was fair/moderate short-term reproducibility (κ<0.5) for all morphological features. At 1-year, compared to standard OGTT criteria, the ROC-AUCs for glucose peak >30 mins, 1-hr ≥155mg/dL or a combination of the 2 criteria were comparable (all P>0.05), but the monophasic curve had the lowest ROC-AUC (P<0.001). Conclusion: In adolescent girls with obesity, glucose peak > glucose ≥155mg/dL had similar reproducibility and 1-year predictive ability for prediabetes compared to standard OGTT criteria. The shortened 1-hr OGTT may provide diagnostic equivalence for prediabetes risk with the additional advantage of a less time-consuming risk assessment.

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“…122,132,133 The monophasic shape is the predominant shape in individuals with NGT, resulting in high false-positive rates, especially those with prediabetes. 120,122,123,126,132,134 Besides, there is no consistent time factor for categorization, and curve classification may vary depending on the duration of the OGTT. 108 The implications of having a monophasic curve during a 2-h test but a biphasic curve after a 3-h test are unknown.…”

Section: The Ogtt Shape Indexmentioning

confidence: 99%

<p>The Oral Glucose Tolerance Test: 100 Years Later</p>

Jagannathan¹,

Neves²,

Dorcely³

et al. 2020

DMSO

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For over 100 years, the oral glucose tolerance test (OGTT) has been the cornerstone for detecting prediabetes and type 2 diabetes (T2DM). In recent decades, controversies have arisen identifying internationally acceptable cut points using fasting plasma glucose (FPG), 2-h post-load glucose (2-h PG), and/or HbA1c for defining intermediate hyperglycemia (prediabetes). Despite this, there has been a steadfast global consensus of the 2-h PG for defining dysglycemic states during the OGTT. This article reviews the history of the OGTT and recent advances in its application, including the glucose challenge test and mathematical modeling for determining the shape of the glucose curve. Pitfalls of the FPG, 2-h PG during the OGTT, and HbA1c are considered as well. Finally, the associations between the 30-minute and 1-hour plasma glucose (1-h PG) levels derived from the OGTT and incidence of diabetes and its complications will be reviewed. The considerable evidence base supports modifying current screening and diagnostic recommendations with the use of the 1-h PG. Measurement of the 1-h PG level could increase the likelihood of identifying high-risk individuals when the pancreatic ß-cell function is substantially more intact with the added practical advantage of potentially replacing the conventional 2-h OGTT making it more acceptable in the clinical setting.

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Reproducibility and least significant differences of oral glucose tolerance test-derived parameters in a postmenopausal population without diabetes

Cited by 14 publications

References 9 publications

Review of methods for detecting glycemic disorders

Review of methods for detecting glycemic disorders

Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity

<p>The Oral Glucose Tolerance Test: 100 Years Later</p>

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