Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry

Roustit, Matthieu; Blaise, S.; Millet, C.; Cracowski, Jean‐Luc

doi:10.1016/j.mvr.2010.01.001

Cited by 171 publications

(146 citation statements)

References 28 publications

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“…LDF has the advantage of having a well-established theory ( [12]). However, it is a single-point monitoring technique with low reproducibility ( [13], [14]). Based on the LDF principle, laser Doppler imagers have been proposed to obtain 2D perfusion images but they rely on a scan of the zone under study (see, e.g., [15], [16]).…”

mentioning

confidence: 99%

Analysis of Laser Speckle Contrast Images Variability Using a Novel Empirical Mode Decomposition: Comparison of Results With Laser Doppler Flowmetry Signals Variability

Humeau-Heurtier

Ábrahám

2015

IEEE Trans. Med. Imaging

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noise (CEEMDAN). CEEMDAN is suitable for non linear and non stationary data and leads to intrinsic mode functions (IMFs). It is based on the ensemble empirical mode decomposition (EEMD) which relies on empirical mode decomposition (EMD). In our work the average frequencies of LSCI IMFsgiven by CEEMDAN are compared with the ones given by EMD and EEMD. Moreover, LDF signals acquired simultaneously to LSCI data are also processed with CEEMDAN, EMD and EEMD. We show that the average frequencies of IMFs given by CEEMDAN depend on the signal to noise ratio (SNR) used in the computation but, for a given SNR, the average frequencies found for LSCI are close to the ones obtained for LDF. By opposition, EEMD leads to IMFs with frequencies that do not vary much when the SNR level is higher than a threshold. The new CEEMDAN algorithm has the advantage of achieving a complete decomposition with no error in the reconstruction but our study suggests that further work is needed to gain knowledge in the adjustment of the added noise level. CEEMDAN, EMD and EEMD are data-driven methods that can provide a better knowledge of LSCI.Index Terms-Laser speckle contrast imaging, Empirical mode decomposition, Biomedical image processing, Laser Doppler flowmetry, Microvascular blood flow.

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mentioning

confidence: 99%

Analysis of Laser Speckle Contrast Images Variability Using a Novel Empirical Mode Decomposition: Comparison of Results With Laser Doppler Flowmetry Signals Variability

Humeau-Heurtier

Ábrahám

2015

IEEE Trans. Med. Imaging

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“…Although such measurements are proportional to flow, the factor of proportionality will be different for different tissues [11]. Because each subject showed individual variations in blood flow, the relative change from the base line measurement for each participant was used to evaluate the impact of the mattress [12].…”

Section: Discussionmentioning

confidence: 99%

Finite Element Analysis and Empirical Analysis of a Cost-effective Pressure Ulcer-Preventing Mattress

Lai

Guo

2015

AUSMT

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Pressure relief mattresses are recommended to prevent pressure ulcers (PU). Passive mattresses offer a cost advantage over dynamic mattresses. This study evaluates a new passive PU-preventing mattress. Finite element analysis was used to determine the curved surface design of a mushroom-shaped support. A novel mattress evaluation platform was developed integrating a pressure mapping sensor, laser doppler flowmetry (LDF) and precise temperature sensors to validate the effectiveness of the new passive mattress. Compared with standard hospital mattresses, the new passive mattress was found to provide a more even body pressure distribution (relative disparity of -0.7%) and better assisted subcutaneous blood flow (relative disparity of 18.78%). Experimental results demonstrated that the new passive mattress can provide an effective and economical solution for preventing PU.

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“…We have previously shown that the inter-individual coefficients of variation (CV) for resting BF and SO 2 measured using the combined probe in a cohort of 10 healthy individuals at ambient room temperature was 0.15 and 0.09, respectively [20] (CV values of <0.35 deemed as acceptable [24]). The inter-individual CVs for oxyHb, deoxyHb, and totalHb were 0.19, 0.09 and 0.10, respectively (n = 10).…”

Section: B Capture Of Laser Doppler and Oxy Signalsmentioning

confidence: 99%

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

Kuliga

Gush

Clough

et al. 2017

IEEE Trans. Biomed. Eng.

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Abstract-Objective:This study investigates the timedependent behaviour and algorithmic complexity of low frequency, periodic oscillations in blood flux and oxygenation signals from the microvasculature. Methods: Microvascular blood flux (BF) and oxygenation (OXY: oxyHb, deoxyHb, totalHb and SO 2 %) was recorded from 15 healthy young adult males using combined laser Doppler fluximetry and white light spectroscopy with local skin temperature clamped to 33°C and during local thermal hyperaemia (LTH) at 43°C. Power spectral density (PSD) of the BF and OXY signals was evaluated within the frequency range (0.0095-1.6Hz). Signal complexity was determined using the Lempel-Ziv (LZ) algorithm. Results: Foldincrease in BF during LTH was 15.6 (10.3,22.8) and in OxyHb 4.8 (3.5,5.9) (median, range). All BF and OXY signals exhibited multiple oscillatory components with clear differences in signal power distribution across frequency bands at 33°C and 43°C. Significant reduction in the intrinsic variability and complexity of the microvascular signals during LTH was found, with mean LZ complexity of BF and OxyHb falling by 25% and 49%, respectively (p<0.001). Conclusion: These results provide corroboration that in human skin microvascular blood flow and oxygenation are influenced by multiple, time-varying oscillators that adapt to local influences and become more predictable during increased haemodynamic flow. Significance: Recent evidence strongly suggests that the inability of microvascular networks to adapt to an imposed stressor is symptomatic of disease risk which might be assessed via BF and OXY via the combination signal analysis techniques described here.

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Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry

Cited by 171 publications

References 28 publications

Analysis of Laser Speckle Contrast Images Variability Using a Novel Empirical Mode Decomposition: Comparison of Results With Laser Doppler Flowmetry Signals Variability

Analysis of Laser Speckle Contrast Images Variability Using a Novel Empirical Mode Decomposition: Comparison of Results With Laser Doppler Flowmetry Signals Variability

Finite Element Analysis and Empirical Analysis of a Cost-effective Pressure Ulcer-Preventing Mattress

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

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