Reproducibility and reliability of the 13C-acetate breath test to measure gastric emptying of liquid meal in infants

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

“…In the current study, we demonstrated a strong relationship between breath test and scintigraphic measurement of GE, in both patients (r 2 =0.44–0.71) and healthy subjects (r 2 =0.37–0.64), with acceptable limits of agreement between the two techniques. This is consistent with studies reported by other groups 45 52 54. These data, therefore, support a potential role for breath testing in critically ill patients for epidemiological, physiological and drug studies on GE.…”

“…However, the emptying of liquid nutrient is more relevant in a critically ill population and this is only the second study validating the use of breath tests for the measurement of liquid nutrient emptying, and the first in an adult population. In the previous study, breath tests were validated to measure GE of milk in a paediatric group 52. Although breath tests have been used to measure GE in critically ill patients,53 the rate of excretion of markers into expiratory gases could possibly be affected by factors other than GE, including small intestinal absorption and hepatic metabolism.…”

Variability of the 13C‐Acetate Breath Test for Gastric Emptying of Liquids in Healthy Children

“…The 13 C-ABT using IRMS has been validated against scintigraphy in adults and children for the measurement of GE of liquids and semisolids (16,21,23,24,30). Braden Applying the 13 C-ABT using NDIRS in healthy children, we obtained a median CV of 8.3% for t 1/2 , a median CV of 16.6% for t lag , and a median CV of 4.3% for GEC for GE of liquids.…”

Developmental Changes in Pharmacokinetics and Pharmacodynamics

“…Another application of stable isotope breath tests resides with the use of the 13 C‐acetate test to assess gastric emptying in infants and children . In a more recent study, Jones et al found a predictive association between scintigraphy‐determined (with 99m‐technetium) gastric emptying time and that estimated using exhaled 13 CO 2 from the 13 C‐acetate breath test.…”