Introduction. Amyloidosis is a disease associated with the extracellular
deposition of insoluble protein material called amyloid. It can be acquired
or hereditary, systemic or organ-limited. Nodular pulmonary amyloidosis is
defined as one or more tumefactive amyloid deposits in the lungs. Case
outlines. This study presents two cases that were hospitalized at the
Institute for Pulmonary Diseases to clarify the origin of lesions detected
on CT scans of lung parenchyma. In the first case, in a 78-year-old woman,
numerous non-calcified nodules were described on the chest CT. The patient
died during hospitalization, and the autopsy revealed diffusely distributed
greyish-yellow nodular lesions in the upper and middle parts of the right
lung, as well as lesions in the form of partially calcified nodules in both
lungs. Histological analysis of samples from macroscopically described
nodules confirmed nodular amyloidosis. The patient from the second presented
case is a male, 58 years old, who was operated on for rectal adenocarcinoma
three years ago. A CT scan of the lung parenchyma shows a tumor nodule
localized in the lower lobe and a nodular lesion localized in the upper lobe
of the right lung. Histological analysis confirmed that the lesion from the
lower lobe corresponds to the metastasis of colorectal cancer, while in the
lesion from the upper lobe amyloid deposits were found. Conclusion.
Pulmonary nodular amyloidosis is a rare condition, and because of the
imaging similarities it is difficult to distinguish it from malignant
nodules in the lung parenchyma. Therefore, as a part of routine practice, a
definitive diagnosis of amyloidosis needs to be confirmed by tissue biopsy.