Reproducibility and validity of ultrasound for the measurement of visceral and subcutaneous adipose tissues

Schlecht, Inga; Wiggermann, Philipp; Behrens, Gundula; Fischer, Beate; Koch, Manja; Freese, J.; Rubin, D L; Nöthlings, Ute; Stroszczynski, Christian; Leitzmann, Michael F.

doi:10.1016/j.metabol.2014.07.012

Cited by 38 publications

(28 citation statements)

References 29 publications

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“…Also, abdominal fat levels were not assessed using the gold standard techniques of CT or MRI scanning but rather used ultrasound. However, this method has been favourably validated against MRI [34, 35]. A further limitation of this study was the lack of assessment of ectopic fat deposition, particularly within the liver.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease

et al. 2016

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BackgroundThe aetiology of the metabolic syndrome and the inter-relationship between risk factors for this syndrome are poorly understood. The purpose of this investigation was to determine the risk factors for metabolic syndrome and their interactions in a cohort of women with a high prevalence of metabolic syndrome.Materials and MethodsAbdominal and whole body composition (ultrasound and dual-energy X-ray absorptiometry), blood pressure, and cardiometabolic and demographic factors were measured in a cross-sectional study of 702 black African women from Soweto, Johannesburg. Data was analysed using multivariate logistic regression.ResultsMetabolic syndrome was present in 49.6% of the study cohort. Logistic regression analysis demonstrated that adiponectin (odds ratio [95% CIs]: 0.84 [0.77, 0.92], p<0.0005) and abdominal subcutaneous fat (0.56 [0.39, 0.79], p = 0.001) reduced metabolic syndrome risk whilst insulin resistance (1.31 [1.16, 1.48], p<0.0005) and trunk fat-free soft-tissue mass (1.34 [1.10, 1.61], p = 0.002) increased risk. Within this group of risk factors, the relationship of adiponectin with metabolic syndrome risk, when analysed across adiponectin hexiles, was the least affected by adjustment for the other risk factors.ConclusionsAdiponectin has a significant protective role against metabolic syndrome and is independent of other risk factors. The protective and possible augmentive effects of abdominal subcutaneous fat and lean trunk mass, respectively on metabolic syndrome risk demonstrate the existence of novel interactions between body composition and cardiometabolic disease.

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Section: Discussionmentioning

confidence: 99%

Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease

et al. 2016

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“…Other measures such as a multisliced MRI provides volume but was not a feasible method in the current studies. Ultrasound is well validated against two-dimensional MRI and CT scans in several studies in different populations 42 43…”

Section: Discussionmentioning

confidence: 99%

Ethnic differences in anthropometric measures and abdominal fat distribution: a cross-sectional pooled study in Inuit, Africans and Europeans

Rønn

Andersen

Lauritzen

et al. 2017

J Epidemiol Community Health

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“…Although gold standard methods to measure VAT and SAT are magnetic resonance imaging (MRI) or computer tomography (CT), these approaches are limited in field conditions due to the associated costs and issues regarding accessibility, and in terms of CT potential adverse effects of radiation. We recently reported that ultrasound represents a suitable technique to assess VAT and SAT accurately and reproducibly in epidemiologic research settings [31]. A further asset of our study is that we considered several different body fat measures and conducted informative stratified analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Measurements were performed according to a strict protocol, details of which are described elsewhere [31]. Briefly, at the median line SAT was measured extending from the skin to the linea alba and VAT was measured reaching from the linea alba to the lumbar vertebra corpus.…”

Section: Methodsmentioning

confidence: 99%

Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites

et al. 2017

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Obesity is a complex multifactorial phenotype that influences several metabolic pathways. Yet, few studies have examined the relations of different body fat compartments to urinary and serum metabolites. Anthropometric phenotypes (visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), the ratio between VAT and SAT (VSR), body mass index (BMI), waist circumference (WC)) and urinary and serum metabolite concentrations measured by nuclear magnetic resonance spectroscopy were measured in a population-based sample of 228 healthy adults. Multivariable linear and logistic regression models, corrected for multiple testing using the false discovery rate, were used to associate anthropometric phenotypes with metabolites. We adjusted for potential confounding variables: age, sex, smoking, physical activity, menopausal status, estimated glomerular filtration rate (eGFR), urinary glucose, and fasting status. In a fully adjusted logistic regression model dichotomized for the absence or presence of quantifiable metabolite amounts, VAT, BMI and WC were inversely related to urinary choline (ß = -0.18, p = 2.73*10−3), glycolic acid (ß = -0.20, 0.02), and guanidinoacetic acid (ß = -0.12, p = 0.04), and positively related to ethanolamine (ß = 0.18, p = 0.02) and dimethylamine (ß = 0.32, p = 0.02). BMI and WC were additionally inversely related to urinary glutamine and lactic acid. Moreover, WC was inversely associated with the detection of serine. VAT, but none of the other anthropometric parameters, was related to serum essential amino acids, such as valine, isoleucine, and phenylalanine among men. Compared to other adiposity measures, VAT demonstrated the strongest and most significant relations to urinary and serum metabolites. The distinct relations of VAT, SAT, VSR, BMI, and WC to metabolites emphasize the importance of accurately differentiating between body fat compartments when evaluating the potential role of metabolic regulation in the development of obesity-related diseases, such as insulin resistance, type 2 diabetes, and cardiovascular disease.

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Reproducibility and validity of ultrasound for the measurement of visceral and subcutaneous adipose tissues

Cited by 38 publications

References 29 publications

Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease

Metabolic and Body Composition Risk Factors Associated with Metabolic Syndrome in a Cohort of Women with a High Prevalence of Cardiometabolic Disease

Ethnic differences in anthropometric measures and abdominal fat distribution: a cross-sectional pooled study in Inuit, Africans and Europeans

Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites

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