Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Bisdas, Sotirios; Bohning, Daryl E.; Bešenski, Nada; Nicholas, J. Skye; Rumboldt, Zoran

doi:10.3174/ajnr.a1044

Cited by 74 publications

(59 citation statements)

References 28 publications

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“…There are a few studies reporting ADC 20,47 and FA values in the normal population. 20, 48 The values we found for FA are generally lower than the reference values for the normal population according to Brander et al 20 FA values in the subcortical cerebellum are reported to be higher in normal subjects, as compared with our patients. 39 Also, ADC at the posterior limb of internal capsule and subcortical cerebellum are considerably higher in our population compared with those found by Helenius et al 47 There might be a modification of DTI parameters (reduction of FA and increase in ADC) in patients with acute SAH that has to be confirmed in further studies.…”

Section: August 2017contrasting

confidence: 36%

Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage

Fragata

Alves

Papoila

et al. 2017

Stroke

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Background and Purpose-Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at <72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score ≥3). Methods-DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at <72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at <72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis. Results-At <72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy; P=0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (P=0.061). Conclusions-DTI

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Section: August 2017contrasting

confidence: 36%

Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage

Fragata

Alves

Papoila

et al. 2017

Stroke

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“…Jansen and colleagues performed two scans on 10 healthy subjects, noting median lobar DTI(FA) values for ICC of 0.75–0.86 (Jansen, Kooi, Kessels, Nicolay, & Backes, 2007). Bisdas and colleagues performed two scans separated by 2 weeks on 12 subjects, noting low individual FA tract MCV (0.4%–10%) (Bisdas, Bohning, Besenski, Nicholas, & Rumboldt, 2008). Vollmar and colleagues noted FA MCV of 0.8%–3.0% and ICC of 0.82–0.99 in nine subjects, with the whole‐brain average FA showing the smallest MCV (Vollmar et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of quantitative structural and physiological MRI measurements

et al. 2017

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IntroductionQuantitative longitudinal magnetic resonance imaging and spectroscopy (MRI/S) is used to assess progress of brain disorders and treatment effects. Understanding the significance of MRI/S changes requires knowledge of the inherent technical and physiological consistency of these measurements. This longitudinal study examined the variance and reproducibility of commonly used quantitative MRI/S measurements in healthy subjects while controlling physiological and technical parameters.MethodsTwenty‐five subjects were imaged three times over 5 days on a Siemens 3T Verio scanner equipped with a 32‐channel phase array coil. Structural (T1, T2‐weighted, and diffusion‐weighted imaging) and physiological (pseudocontinuous arterial spin labeling, proton magnetic resonance spectroscopy) data were collected. Consistency of repeated images was evaluated with mean relative difference, mean coefficient of variation, and intraclass correlation (ICC). Finally, a “reproducibility rating” was calculated based on the number of subjects needed for a 3% and 10% difference.ResultsStructural measurements generally demonstrated excellent reproducibility (ICCs 0.872–0.998) with a few exceptions. Moderate‐to‐low reproducibility was observed for fractional anisotropy measurements in fornix and corticospinal tracts, for cortical gray matter thickness in the entorhinal, insula, and medial orbitofrontal regions, and for the count of the periependymal hyperintensive white matter regions. The reproducibility of physiological measurements ranged from excellent for most of the magnetic resonance spectroscopy measurements to moderate for permeability‐diffusivity coefficients in cingulate gray matter to low for regional blood flow in gray and white matter.DiscussionThis study demonstrates a high degree of longitudinal consistency across structural and physiological measurements in healthy subjects, defining the inherent variability in these commonly used sequences. Additionally, this study identifies those areas where caution should be exercised in interpretation. Understanding this variability can serve as the basis for interpretation of MRI/S data in the assessment of neurological disorders and treatment effects.

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“…However, it has been illustrated that the imaging processing pipeline is important for reproducibility (Vollmar, O'Muircheartaigh et al 2010). The differences in DTI due to different numbers of diffusion gradients and acquisition parameters are small relative to the variability of FA measures between sessions, which is in accordance with previous systematic evaluation of the reproducibility of FA (Bisdas, Bohning et al 2008, Vollmar, O'Muircheartaigh et al 2010. Whole brain analysis has good reproducibility but cannot be sensitive to pathological changes in clinical studies because it is hard to estimate the pathological state of the tissue (Jansen, Kooi et al 2007, Assaf andPasternak 2008).…”

Section: Serial Mri Studiessupporting

confidence: 89%

Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype

Alruwaili¹

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Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value

Cited by 74 publications

References 28 publications

Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage

Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage

Reproducibility of quantitative structural and physiological MRI measurements

Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype

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