Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI

Leontiev, Oleg; Buxton, Richard B.

doi:10.1016/j.neuroimage.2006.10.044

Cited by 161 publications

(150 citation statements)

References 33 publications

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“…These numbers are in agreement with the number of voxels detected as significantly active in this study. Despite the lower SNR, we observed a lower coefficient of variation for CBF percent signal change compared to BOLD, implying a higher reproducibility of CBF values, in agreement with previous studies (Leontiev and Buxton, 2007; Tjandra et al, 2005). …”

Section: Discussionsupporting

confidence: 92%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

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A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective regions using, for the first time, cerebral blood flow (CBF). We demonstrated the feasibility of CBF‐based tonotopy and found a good agreement with BOLD signal‐based tonotopy, despite the lower contrast‐to‐noise ratio of CBF. Quantitative perfusion mapping of baseline CBF showed a region of high perfusion centered on Heschl's gyrus and corresponding to the main high‐low‐high frequency gradients, co‐located to the presumed primary auditory core and suggesting baseline CBF as a novel marker for AC parcellation. Furthermore, susceptibility weighted imaging was employed to investigate the tissue specificity of CBF and BOLD signal and the possible venous bias of BOLD‐based tonotopy. For BOLD only active voxels, we found a higher percentage of vein contamination than for CBF only active voxels. Taken together, we demonstrated that both baseline and stimulus‐induced CBF is an alternative fMRI approach to the standard BOLD signal to study auditory processing and delineate the functional organization of the auditory cortex. Hum Brain Mapp 38:1140–1154, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 92%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

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“…Hypercapnia data were acquired for determination of the BOLD scaling factor, M, with results similar to previously reported values (Chiarelli et al, 2007a;Davis et al, 1998;Leontiev and Buxton, 2007a). Functional runs were acquired to enable the determination of an ROI within the visual cortex and to allow comparison of the coupling of CBF and CMRO 2 under the different conditions of visual stimulation and caffeine consumption.…”

Section: Discussionmentioning

confidence: 63%

“…The coupling between changes in blood flow and oxygen metabolism can be described by the ratio, n, of the fractional CBF change to the fractional CMRO 2 change. Previous calibrated-BOLD studies have typically reported a strong coupling between CBF and CMRO 2 changes during brain activation, with n values in the range 2-3 observed in the visual cortex in response to visual stimulation (Chiarelli et al, 2007a;Davis et al, 1998;Hoge et al, 1999;Kim et al, 1999;Leontiev and Buxton, 2007a). Regional differences in n across the brain have also been reported (Chiarelli et al, 2007a).…”

Section: Introductionmentioning

confidence: 97%

Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: A calibrated BOLD fMRI study

et al. 2008

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Although functional MRI (fMRI) based on blood oxygenation-level dependent (BOLD) signal changes is a sensitive tool for mapping brain activation, quantitative studies of the physiological effects of pharmacological agents using fMRI alone are difficult to interpret due to the complexities inherent in the BOLD response. Hypercapnia calibrated-BOLD methodology is potentially a more powerful physiological probe of brain function, providing measures of the changes in cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO 2 ). In this study, we implemented a quantitative R 2 * approach for assessing the BOLD response to improve the stability of repeated measurements, in combination with the calibrated-BOLD method, to examine the CBF and CMRO 2 responses to caffeine ingestion. Ten regular caffeine consumers were imaged before and after a 200mg caffeine dose. A dual echo arterial spin labeling technique was used to measure CBF and BOLD responses to visual stimulation, caffeine consumption and mild hypercapnia. For a region of interest defined by CBF activation to the visual stimulus, the results were: hypercapnia increased CBF (+46.6%, ±11.3, mean and standard error), visual stimulation increased both CBF (+47.9%, ±2.9) and CMRO 2 (+20.7%, ±1.4), and caffeine decreased CBF (-34.5%, ±2.6) with a non-significant change in CMRO 2 (+5.2%, ±6.4). The coupling between CBF and CMRO 2 was significantly different in response to visual stimulation compared to caffeine consumption. A calibrated-BOLD methodology using R 2 * is a promising approach for evaluating CBF and CMRO 2 changes in response to pharmacological interventions. Keywordsfunctional magnetic resonance imaging (fMRI); blood oxygenation level dependent (BOLD); cerebral blood flow (CBF); cerebral metabolic rate of oxygen (CMRO2); calibrated-BOLD; caffeine

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“…Unlike conventional T2 mapping, TRUST uses T2-preparation to modulate T2-weighting and also uses composite pulses and RF phase cycling to minimize the effect of RF imperfection on T2 value, thus the conversion from T2 to Yv is more accurate (Lu et al, 2011). Most existing noninvasive MRI techniques for CMRO 2 quantification involve special physiological challenges such as hypercapnia or hyperoxia (Chiarelli et al, 2007;Leontiev and Buxton, 2007) and/or exogenous agents (e.g., caffeine). These so-called calibrated functional MRI techniques are sensitive to changes of CMRO 2 but not to the baseline values; therefore, they may not be suitable for routine clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Characterizing Brain Oxygen Metabolism in Patients with Multiple Sclerosis with T2-Relaxation-Under-Spin-Tagging MRI

Zhang

Lu³

et al. 2012

J Cereb Blood Flow Metab

143

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In this study, venous oxygen saturation and oxygen metabolic changes in multiple sclerosis (MS) patients were assessed using a recently developed T2-relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI), which measures the superior sagittal venous sinus blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO 2 ), an index of global oxygen consumption. Thirty patients with relapsing-remitting MS and 30 age-matched healthy controls were studied using TRUST at 3 T MR. The mean expanded disability status scale (EDSS) of the patients was 2.3 (range, 0 to 5.5). We found significantly increased Yv (P < 0.0001) and decreased CMRO 2 (P = 0.003) in MS patients (mean±s.d.: 65.9%±5.1% and 138.8±35.4 lmol per 100 g per minute) as compared with healthy control subjects (60.2% ± 4.0% and 180.2 ± 24.8 lmol per 100 g per minute, respectively), implying decrease of oxygen consumption in MS. There was a significant positive correlation between Yv and EDSS and between Yv and lesion load in MS patients (n = 30); on the contrary, there was a significant negative correlation between CMRO 2 and EDSS and between CMRO 2 and lesion load (n = 12). There was no correlation between Yv and brain atrophy measures. This study showed preliminary evidence of the potential utility of TRUST in global oxygen metabolism. Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease.

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Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI

Cited by 161 publications

References 33 publications

Tonotopic maps in human auditory cortex using arterial spin labeling

Tonotopic maps in human auditory cortex using arterial spin labeling

Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: A calibrated BOLD fMRI study

Characterizing Brain Oxygen Metabolism in Patients with Multiple Sclerosis with T2-Relaxation-Under-Spin-Tagging MRI

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