Reproducibility of histologic classification of gastric cancer

Palli, Domenico; Bianchi, Simonetta; Cipriani, Francesco; Duca, Piergiorgio; Amorosi, Andrea; Avellini, Claudio; Russo, Antonio; A, Saragoni; Todde, Pierfelice; Valdés, E. López

doi:10.1038/bjc.1991.171

Cited by 51 publications

(40 citation statements)

References 4 publications

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“…17 The dominant histologic type of cancer was adenocarcinoma in which tubular subtype predominated (71.5%). Similar finding was observed by study done by Pallil D et al 18 who found 74% of cancer being adenocarcinoma. Signet ringtype was the second most frequent type of adenocarcinoma which was PAS stain positive ( fig.2).…”

Section: Discussionsupporting

confidence: 90%

Incidence of gastric cancer, its subtypes, and correlation with Helicobacter Pylori

Kc¹,

Amatya²,

Lakhey

et al. 2013

J Pathol Nep

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Background: Gastric cancer is the fourth most commonly diagnosed cancer and the second most common cause of cancer related death worldwide. It is the common cause of cancer related death in Nepal. Helicobacter Pylori has been classifi ed as a defi nite carcinogen along with other factors. The aim of this study was to fi nd the incidence of gastric cancer among the patients undergoing upper gastroscopy, its various subtypes and association with Helicobacter Pylori. Materials and Methods:This is a retrospective and prospective study carried out at GRP Polyclinic and Kist Medical College Teaching Hospital. All the patients undergoing upper gastrointestinal endoscopy were included in this study. Data of all the gastric endoscopic biopsies done from June 2011 to January 2013 were collected and analyzed. All the biopsy specimens were processed routinely in histopathology laboratory. Specimens showing carcinoma were enrolled in this study and all the relevant demographic data were collected. Results:Out of 3395 biopsy cases; 49 cases (1.44%) were diagnosed as adenocarcinoma stomach. The overall mean age for carcinoma was 47.6 years with a mild male preponderance. Thirty cases (61.2%) were of intestinal type, (n=11; 22.4%) were of diffuse type and (n=8; 16.3%) were mixed type of adenocarcinoma. According to WHO classifi cation the most common subtype was tubular adenocarcinoma (n=35; 71.5%) followed by signet ring type (11 cases; 22.4%). Out of 49 cases of adenocarcinoma stomach 39 cases (79.5%) were Helicobacter Pylori positive. Conclusion:This study shows that gastric carcinoma is a male predominant neoplasm usually of old age but can occur at younger ages. It predominantly occurs in Helicobacter Pylori infected patients and H. Pylori eradication will help to decrease the incidence rate and mortality of stomach cancer.

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Section: Discussionsupporting

confidence: 90%

Incidence of gastric cancer, its subtypes, and correlation with Helicobacter Pylori

Kc¹,

Amatya²,

Lakhey

et al. 2013

J Pathol Nep

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“…Details of the study protocol have been published elsewhere (Buiatti et al, 1989b(Buiatti et al, , 1990 (Buiatti et al, 1989b (Buiatti et al, 1991;Palli et al, 1991 (Fidanza & Versiglioni, 1988) (0) - (0) - (0) 3 (100) All others 146 (48) 98 (32) 20 (7) 41 (13) previous gastric surgery. For each site, risks decreased with increasing social class, and were higher in residents of rural than urban areas.…”

Section: Methodsmentioning

confidence: 99%

A case-control study of cancers of the gastric cardia in Italy

et al. 1992

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Summary In a case-control study of gastric cancer (GC) only a weak association with total alcohol intake. Cardia tumours showed a greater familial occurrence of GC than did other sites, with a 7-fold increase in risk for those reporting two first-degree relatives with GC. The authors discuss these findings in view of the rising incidence of adenocarcinomas of the cardia and lower oesophagus that has been reported in some western countries.

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“…The underlying reasons to the differences shown in these reports remain elusive at this point. One of the possibilities is that classifying gastric cancer by Lauren's subtypes could have high inter-observer variabilities (66,67). Since there is no "gold standard" for defining the Lauren's classification, discordance between pathologists vary from 20-30% and there also exists a considerable portion of mixed-type gastric cancer.…”

Section: Yap Signatures Are Enriched In a Subpopulation Of Human Gastmentioning

confidence: 99%