Reproducibility of In Vivo Carotid Intima-Media Thickness Measurements

Abstract

We conclude that a consensus concerning the assessment of IMT is urgently needed. Variability of IMT measurements is lowest when determining the mean thickness in the common carotid artery in different directions.

Manual or semi‐automated edge detection of the maximal far wall common carotid intima–media thickness: a direct comparison

“…The effect of semi-automated edge detection on the extent of reduction in measurement variability depends on the contribution of sonographers and readers to the total variability. A number of studies have indicated that differences between sonographers have a relatively larger effect on the CIMT measurements than differences between readers [15][16][17]. Indeed, reproducibility results from a study with images that were read using semi-automated edge detection were similar to those reported from other studies in which CIMT reading was performed manually [16].…”

Validation of a Carotid Intima-Media Thickness Border Detection Program for Use in an Office Setting

“…As expected, the reproducibility of the EXP reader was better than that of the NOV reader; however, CV for the measurements using BDP were excellent and comparable with other studies. 9,14,15 Measurements by both NOV and EXP readers correlated strongly with those of the REF laboratory with minimal systematic bias, and bioequivalence was demonstrated. BlandAltman plots and linear regression models for mean and maximum CIMT values successfully illustrate the striking similarity between the readers using BDP and the REF laboratory, and high intrareader repeatability.…”

Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men

“…We used carotidfemoral PWV and CIMT as surrogate measures for structural and functional abnormality of the arterial wall as they have shown to be valid and reproducible methods that are simple and non-invasive. 22,23 A major concern in studies that relate the biomarkers to disease is confounding by a third variable through unknown mechanisms. Consistent with previous evidence, our finding showed that most of the established cardiovascular risk factors are determinants of aortic PWV and CIMT.…”