Reproducibility of in vivo magnetic resonance imaging T<sub>1</sub>rho and T<sub>2</sub> relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Nemeth, Angeline; Marco, L. Di; Boutitie, Florent; Sdika, Michaël; Grenier, Denis; Rabilloud, Muriel; Beuf, Olivier; Pialat, Jean‐Baptiste

doi:10.1002/jmri.25799

Cited by 23 publications

(29 citation statements)

References 35 publications

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“…in vivo reproducibility is affected not only by the intrinsic reproducibility of the technique, but also by subject and slice positioning, and segmentation. A recent in vivo reproducibility study reported 6% intrascanner variability for hip cartilage T 2 , whereas for our technique both intra‐ and interscanner T 2 variability were below 6%. Bittersohl et al repeatedly scanned 15 asymptomatic volunteers and reported 3.7–6.8% variability for the mean T 1 in the hip cartilage, whereas we found nearly perfect T 1 reproducibility.…”

Section: Discussioncontrasting

confidence: 52%

“…Our technique simultaneously yields high‐resolution PD, T 1 , and T 2 maps for six radial sections of the hip in 7:13 minutes, or 1:12 minutes scan time per slice when used in an interleaved multislice protocol. Previous work reported 17:41 minutes to acquire a single coronal T 2 map of the hip with 0.3 × 0.3 × 4.0 mm 3 resolution, and 11 minutes to acquire a 3D sagittal T 2 map of the hip with 0.4 × 0.4 × 1.5 mm 3 resolution . A scan time of ~9 minutes was reported for 3D T 1 mapping of the hip at 1.5 T with 0.8 mm isotropic resolution .…”

Section: Discussionmentioning

confidence: 99%

“…Previous work reported 17:41 minutes to acquire a single coronal T 2 map of the hip with 0.3 × 0.3 × 4.0 mm 3 resolution, 11 and 11 minutes to acquire a 3D sagittal T 2 map of the hip with 0.4 × 0.4 × 1.5 mm 3 resolution. 21 A scan time of~9 minutes was reported for 3D T 1 mapping of the hip at 1.5 T with 0.8 mm isotropic resolution. 22 However, a variable flip-angle T 1 mapping technique was used, which at 3 T requires an additional B 1 correction prescan.…”

Section: Discussionmentioning

confidence: 99%

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Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Cloos

Assländer

Abbas

et al. 2018

Magnetic Resonance Imaging

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Background Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. Purpose To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Study Type Reproducibility, technical validation. Subjects/Phantom A seven‐compartment phantom and three healthy volunteers. Field Strength/Sequence A novel MR pulse sequence that simultaneously measures proton density (PD), T1, and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow. Assessment Intra‐ and interscanner variability of our technique was assessed over multiple scans on three different MR scanners. Statistical Tests For each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance). Results The estimation error for T1 and T2 with respect to reference standard measurements was less than 3% on average for the phantom. The average interscanner coefficient of variation was 1.5% (1.2–1.9%) and 0.9% (0.0–3.7%) for T1 and T2, respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1, and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99% and 5.46% for T1 and T2, respectively. in vivo intrascanner variability was 1.15% for T1 and 3.24% for T2. Data Conclusion Our method, which includes slice positioning, model‐based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:810–815.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Cloos

Assländer

Abbas

et al. 2018

Magnetic Resonance Imaging

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“…Concerning body mass index, literature shows contradictory results. A recent study found correlation between body mass index and T 1ρ in the knee [38] while others decline a relation between body mass index and T 1ρ values in hip cartilage and intervertebral disc cartilage, respectively [39,40]. In our study, body mass index was not correlated to T 1ρ values.…”

Section: Discussioncontrasting

confidence: 81%

T1ρ-mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability

Barendregt

Mazzoli

et al. 2019

Pediatr Radiol

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Background Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage. Objective To study the feasibility and repeatability of T 1ρ for assessing knee cartilage in JIA and also to describe T 1ρ values and study correlation between T 1ρ and conventional MRI scores for disease activity. Materials and methods Thirteen children with JIA or suspected JIA underwent 3-tesla (T) knee MRI that included conventional sequences and a T 1ρ sequence. Segmentation of knee cartilage was carried out on T 1ρ images. We used intraclass correlation coefficient to study the repeatability of segmentation in a subset of five children. We used the juvenile arthritis MRI scoring system to discriminate inflamed from non-inflamed knees. The Mann-Whitney U and Spearman correlation compared T 1ρ between children with and without arthritis on MRI and correlated T 1ρ with the juvenile arthritis MRI score. Results All children successfully completed the MRI examination. No images were excluded because of poor quality. Repeatability of T 1ρ measurement had an intraclass correlation coefficient (ICC) of 0.99 (P<0.001). We observed no structural cartilage damage and found no differences in T 1ρ between children with (n=7) and without (n=6) inflamed knees (37.8 ms vs. 31.7 ms, P=0.20). However, we observed a moderate correlation between T 1ρ values and the juvenile arthritis MRI synovitis score (r=0.59, P=0.04). Conclusion This pilot study suggests that T 1ρ is a feasible and repeatable quantitative imaging technique in children. T 1ρ values were associated with the juvenile arthritis MRI synovitis score.

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“…An MRF‐based methodology was introduced to acquire PD, T 1 , and T 2 relaxation time maps along radial sections of the hip based on the plug‐n‐play (PnP‐MRF) method . This method's resolution was within the range of resolutions presented in previous hip mapping methods, with an overall faster scan time.…”

Section: Potential Clinical Usesmentioning

confidence: 99%

Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations

Poorman

Martin

et al. 2019

Magnetic Resonance Imaging

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Magnetic resonance fingerprinting (MRF) is a powerful quantitative MRI technique capable of acquiring multiple property maps simultaneously in a short timeframe. The MRF framework has been adapted to a wide variety of clinical applications, but faces challenges in technical development, and to date has only demonstrated repeatability and reproducibility in small studies. In this review, we discuss the current implementations of MRF and their use in a clinical setting. Based on this analysis, we highlight areas of need that must be addressed before MRF can be fully adopted into the clinic and make recommendations to the MRF community on standardization and validation strategies of MRF techniques. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:675–692.

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Reproducibility of in vivo magnetic resonance imaging T₁rho and T₂ relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Abstract: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1022-1033.

Cited by 23 publications

References 35 publications

Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

T1ρ-mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability

Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations

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Reproducibility of in vivo magnetic resonance imaging T1rho and T2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Abstract: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1022-1033.

Cited by 23 publications

References 35 publications

Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

T1ρ-mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability

Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations

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Product

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Reproducibility of in vivo magnetic resonance imaging T₁rho and T₂ relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Rapid Radial T₁ and T₂ Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting