Reproducibility of non‐invasive measurement and of short‐term variability of blood pressure and heart rate in healthy volunteers.

Dimier-David, L.; Billon, N; Costagliola, Dominique; Jaillon, Patrice; Funck‐Brentano, Christian

doi:10.1111/j.1365-2125.1994.tb04333.x

Cited by 26 publications

(12 citation statements)

References 17 publications

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“…Specifically, studies have shown frequency domain measures of BPV to be highly reproducible in healthy individuals [6,8], but as intraclass correlations were not used in those investigations direct comparisons to the present study are not possible.…”

Section: Discussionmentioning

confidence: 79%

“…Thus, measures of HRV and BPV are attractive means to evaluate changes in cardiovascular health and fitness in response to various interventions including exercise training. The true efficacy of HRV and BPV measures in this respect, however, hinge largely on their day-to-day reproducibility, and as such several investigations have been published in this area in both healthy individuals [8,25,31], and those with cardiovascular disease [11].…”

Section: Introductionmentioning

confidence: 99%

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Reproducibility of heart rate variability and blood pressure variability in individuals with spinal cord injury

et al. 2005

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Individuals with spinal cord injury (SCI) are prone to orthostatic intolerance and an increased risk of cardiovascular disease. The use of heart rate variability (HRV) and blood pressure variability (BPV) as indices of cardiovascular regulation would be valuable in this population; however, their reproducibility has yet to be tested in those with SCI. The purpose of this study was to examine the day-to-day reproducibility of resting HRV and BPV in individuals with SCI. Ten individuals (age 35.9 +/- 13.2 yrs) with chronic (5.4 +/- 7.7 years post injury) SCI (C4-T12; ASIA A-C) participated. On two occasions within a two-week period, 10-minute supine electrocardiogram and Finapres blood pressure recordings were obtained during spontaneous breathing. Computer software calculated frequency domain measures of HRV and BPV (Low frequency (LF) power, High frequency (HF) power, and LF:HF ratio). Intraclass correlations coefficients (R) were used as an index of day-to-day reproducibility, and analyses were conducted on all participants and only those with tetraplegia. For HRV, measures of heart rate, LF, and LF:HF were found to be highly reproducible (R = 0.82-0.88); however, the reproducibility of HF was found to be poor (all participants: R = 0.53, tetraplegia: R = 0.66). Measures of blood pressure as well as systolic BPV also showed high reproducibility (R = 0.72-0.93). Measures of diastolic BPV were less reproducible but still acceptable (R = 0.71-0.89) with the exception of LF:HF(DBP) (R = 0.51). In conclusion, despite the autonomic dysfunction associated with SCI, measures of HRV and BPV may still be used as reproducible indices of autonomic cardiovascular regulation in this population.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Reproducibility of heart rate variability and blood pressure variability in individuals with spinal cord injury

et al. 2005

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“…Studies in other groups, including normal subjects [9], subjects with Type I diabetes [10], chronic angina sufferers [11] and subjects with congestive heart failure [12], have suggested that low-frequency HRV is a reproducible measurement. Those studies dealt largely with measurements from 24 h tapes, which were repeated only once and at varying time intervals.…”

Section: Discussionmentioning

confidence: 99%

Low-frequency heart rate variability: reproducibility in cardiac transplant recipients and normal subjects

et al. 2000

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Heart rate variability is a measure of autonomic nervous influence on the heart. It has been suggested that it could be used to detect autonomic reinnervation to the transplanted heart, but the reproducibility of the measurement is unknown. In the present study, 21 cardiac transplant recipients and 21 normal subjects were recruited. Three measurements of heart rate variability were performed during the day: in the morning, in the early afternoon and in the late afternoon. These tests were then repeated 1 week later and then again 1 week after that, making nine tests in all. The within-subject S.D. was 0.49 log units in normal subjects and 0.79 log units in transplant recipients. In both cases, this is about 15% of the population range. There was significant variation in heart rate variability between different times of day in both groups, and from day to day in transplant recipients. It was concluded that the reproducibility of measurements of heart rate variability is low, and that differences between measurements performed at different times of day should be interpreted with caution.

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“…Indices of autonomic circulatory control have been shown by our group and numerous other investigators to be quite stable over time and between study days at baseline conditions in a variety of study populations. 19,[23][24][25] For this reason a time control group was not justified, and the changes in measurements over time can be assumed to be due primarily to drug effects at the different infusion rates. In addition, although the investigators administering the protocol were unblinded and could have been biased in the assignment of sedation scores, the drug infusion scheme was designed to target specific plasma concentrations, rather than titrating to sedation score.…”

Section: Methodsmentioning

confidence: 99%

Autonomic circulatory and cerebrocortical responses during increasing depth of propofol sedation/hypnosis in humans

Lafreniere

Milne

Brunet

et al. 2000

Can J Anesth/J Can Anesth

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Purpose: To describe the relative effects of graded central nervous system (CNS) depression, using increasing propofol infusion rates, on neurovegetative brainstem-mediated circulatory control mechanisms and higher cortical activity in healthy humans.Methods: Propofol was administered using an infusion scheme designed to achieve three target blood concentrations in ten healthy volunteers. Blood propofol concentrations and sedation scores were determined at baseline, during the three propofol infusion levels, and 30 min into the recovery period. Electroencephalographic (EEG) power was measured in three frequency bands to quantify cortical activity, and autonomic heart rate control was quantified using spontaneous baroreflex assessment and power spectral analysis of pulse interval. Results: Sedation scores closely paralleled propofol blood concentrations (0, 0.53 ± 0.34, 1.24 ± 0.21, 3.11 ± 0.80, and 0.96 ± 0.42 µg·mL -1 at baseline, three infusion levels and recovery respectively), and all subjects were unconscious at the deepest level. Indices of autonomic heart rate control were decreased only at the deepest levels of CNS depression, while EEG effects were apparent at all propofol infusion rates. These EEG effects were frequency specific, with power in the beta band being affected at light levels of sedation, and alpha and delta power altered at deeper levels. Conclusions: The results of this study support a relative preservation of neurovegetative circulatory control mechanisms during the early stages of CNS depression using gradually increasing rates of infusion of propofol. Indices of circulatory control did not reliably reflect depth of sedation.Objectif : Décrire les effets relatifs d'une dépression graduée du système nerveux central (SNC) sur les mécanismes d'origine centrale du contrôle neurovégétatif de la circulation, et l'activité corticale supérieure chez des humains sains, en utilisant des perfusions de propofol à vitesses croissantes. Méthode : Le propofol a été administré, chez dix volontaires en santé, selon un schéma de perfusion conçu pour atteindre trois concentrations sanguines cibles. Les concentrations sanguines de propofol et les scores de sédation ont été déterminés au départ, pendant les trois régimes de perfusion de propofol et à 30 min pendant la récupéra-tion. La puissance électroencéphalographique (EEG) a été mesurée selon trois bandes fréquentielles pour quantifier l'activité corticale, et le contrôle autonome de la fréquence cardiaque a été mesuré à l'aide d'une évaluation baroréflexe spontanée et de l'analyse spectrale de la puissance de l'intervalle pulsé.Résultats : Les scores de sédation ont présenté un étroit parallélisme avec les concentrations sanguines de propofol (0; 0,53 ± 0,34, 1,24 ± 0,21; 3,11 ± 0,80, et 0,96 ± 0,42 µg·mL -1 au début, pendant les trois perfusions et la récupération, respectivement), et tous les sujets ont connu un profond sommeil. Les indices de contrôle autonome de la fréquence cardiaque ont diminué seulement au moment de la plus profonde dépression d...

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Reproducibility of non‐invasive measurement and of short‐term variability of blood pressure and heart rate in healthy volunteers.

Cited by 26 publications

References 17 publications

Reproducibility of heart rate variability and blood pressure variability in individuals with spinal cord injury

Reproducibility of heart rate variability and blood pressure variability in individuals with spinal cord injury

Low-frequency heart rate variability: reproducibility in cardiac transplant recipients and normal subjects

Autonomic circulatory and cerebrocortical responses during increasing depth of propofol sedation/hypnosis in humans

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