Reproducibility of optic disc measurements acquired with spectral‐domain optical coherence tomography

Abstract

Purpose To compare the reproducibility of peripapillary retinal nerve fiber layer (RNFL) measurements of 2 optical coherence tomography (OCT) systems. Methods Fifty‐seven healthy individuals were prospectively selected. Only one eye was randomly chosen. All participants had intraocular pressure less than 21 mmHg and normal standard automated perimetry. Peripapillary RNFL thicknesses were measured with the Cirrus (Carl Zeiss Meditec, Dublin, Ca) and Spectralis (Heidelberg Engineering, Heidelberg, Germany) OCTs. The same operator acquired 3 consecutive series of scans. Left eye data were converted to a right eye format. Intraclass correlation coefficient (ICC), coefficient of variation (COV), and test‐retest variability were calculated for all parameters. Results Mean age was 58.3±11.3 years. The ICC was higher than 0.92 for all parameters of both OCTs. The COV ranged from 1.8% (average thickness, Spectralis) and 2.5% (average thickness, Cirrus) to 5,8% (nasal inferior segment, Spectralis) and 6.4% (2 o’clock segment, Cirrus). Test‐retest variability was lower than 12.2 µm for Cirrus parameters and lower than 10.9 µm for Spectralis parameters. Conclusion Both OCT systems had similar reproducibility of peripapillary RNFL measurements.