Reproducibility of organ position with respiratory gating for liver tumors: use in dose-escalation

Wagman, Raquel; Yorke, Ellen; Giraud, P.; Ford, Eric; Sidhu, K.; Mageras, G.; Minsky, B. D.; Rosenzweig, K.

doi:10.1016/s0360-3016(01)01872-7

Cited by 17 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inaccuracy in tumor localization for radiotherapy may result in either geographic miss of part of the tumor, or higher exposure to normal tissues. Many techniques have been developed to compensate for respiratory motion artifacts in CT and radiation therapy, including breath-hold methods ͑DIBH and ABC͒, 1-4 respiratory gating, [5][6][7][8][9] respiratory correlated CT ͑RCCT͒, 10,11 and 4D-CT. 12 To correct for respiratory motion artifacts in PET, two methods have been reported; Gated-PET ͑GPET͒, 13,14 and respiratory correlated dynamic PET ͑RCDPET͒. 15 All these techniques have tackled the problem of respiratory motion artifacts in CT and PET images separately.…”

Section: Introductionmentioning

confidence: 99%

Quantitation of respiratory motion during 4D‐PET/CT acquisition

et al. 2004

Self Cite

View full text Add to dashboard Cite

We report on the variability of the respiratory motion during 4D-PET/CT acquisition. The respiratory motion for five lung cancer patients was monitored by tracking external markers placed on the abdomen. CT data were acquired over an entire respiratory cycle at each couch position. The x-ray tube status was recorded by the tracking system, for retrospective sorting of the CT data as a function of respiration phase. Each respiratory cycle was sampled in ten equal bins. 4D-PET data were acquired in gated mode, where each breathing cycle was divided into ten 500 ms bins. For both CT and PET acquisition, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to their respiratory phases. The respiratory periods, and average amplitude within each phase bin, acquired in both modality sessions were then analyzed. The average respiratory motion period during 4D-CT was within 18% from that in the 4D-PET sessions. This would reflect up to 1.8% fluctuation in the duration of each 4D-CT bin. This small uncertainty enabled good correlation between CT and PET data, on a phase-to-phase basis. Comparison of the average-amplitude within the respiration trace, between 4D-CT and 4D- PET, on a bin-by-bin basis show a maximum deviation of approximately 15%. This study has proved the feasibility of performing 4D-PET/CT acquisition. Respiratory motion was in most cases consistent between PET and CT sessions, thereby improving both the attenuation correction of PET images, and co-registration of PET and CT images. On the other hand, in two patients, there was an increased partial irregularity in their breathing motion, which would prevent accurately correlating the corresponding PET and CT images.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantitation of respiratory motion during 4D‐PET/CT acquisition

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, liver tumors move significantly during respiration and the use of respiratory gating might allow for dose escalation. [27] In this instance, respiratory gating would be more appropriate than the DIBH technique because it is easier to perform and the advantage of the decreased lung density in the high dose radiation field is not applicable. Other organ sites that can potentially benefit from respiratory control include the stomach, pancreas, breast, and prostate.…”

Section: Discussionmentioning

confidence: 99%

Tumor Motion Control in the Treatment of Non Small Cell Lung Cancer

Rosenzweig¹,

Yorke²,

Amols³

et al. 2005

LCNV

View full text Add to dashboard Cite

show abstract

“…In the U.S., the University of California at Davis has reported on a gated radiotherapy system, developed jointly with Varian Medical Systems, which accepts respiratory signals from a video camera (now commercially available as the Real-Time Position Management Respiratory Gating System, or RPM) [19]. A number of centers have reported on clinical studies with the RPM system, which is described further below [20][21][22][23].…”

Section: Respiratory Gatingmentioning

confidence: 99%

“…For NSCLC patients, we have not reduced the PTV margin that has been used for conventional treatment, but rather assign patients to gated treatment if there is evidence of tumor mobility. Respiratory gated treatment for liver cancer patients has enabled a safe reduction of margins (GTV to PTV) from 2 cm to 1 cm, subject to continuing portal radiograph surveillance during treatment [21].…”

Section: Rpm System Descriptionmentioning

confidence: 99%