Reproducibility of Retinal Nerve Fiber Thickness Measurements Using the Stratus OCT in Normal and Glaucomatous Eyes

Budenz, Donald L.; Chang, Robert; Huang, Xinwei; Knighton, Robert W.; Tielsch, James M.

doi:10.1167/iovs.04-1174

Cited by 264 publications

(223 citation statements)

References 15 publications

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“…With evolution of technology, the accuracy of OCT has significantly improved and RNFL measurement with OCT is considered one of the most reliable methods to estimate the severity of glaucoma patients to date. 12,13 We utilized the same method to investigate the RNFL thickness of RP patients.…”

Section: Discussionmentioning

confidence: 99%

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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Purpose To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP). Design Cross-sectional observational study. Methods One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model. Results The average RNFL thickness was 104.1±21.7 lm. The multiple R 2 for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect. Conclusion RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.

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Section: Discussionmentioning

confidence: 99%

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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“…These instruments have been shown to provide measurements of the RNFL thickness with good repeatability and reproducibility, which are mandatory requisites for accurately assessing a disease and its progression. [7][8][9] Moreover, their measurements have been shown to correlate positively with ex vivo histological measurements of the retina. 10,11 Spectral-domain OCT (SD-OCT) has now replaced TD-OCT and a large number of instruments by different manufacturers are commercially available.…”

Section: Introductionmentioning

confidence: 88%

Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

Savini

Carbonelli²,

Parisi

et al. 2010

Eye

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“…Time-domain OCT provides reproducible RNFLT measurements around the ONH. 14 In this report, SLP-VCC and SLP-ECC imaging modalities are referred to as VCC and ECC respectively, whereas time-domain OCT is referred to as OCT. Previous longitudinal studies have shown that VCC, ECC, and OCT can provide good discrimination in rates of RNFLT change between progressing and non-progressing glaucoma patients determined by visual field changes and/or expertassessed stereophotograph change.…”

Section: Introductionmentioning

confidence: 99%

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

O’Leary

Artes

Hutchison

et al. 2012

Eye

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Purpose To examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and timedomain optical coherence tomography (OCT). Methods Sixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixedeffects models. Results The median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P ¼ 0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (Po0.01) in patients compared with controls. Rates of RNFLT change were not significantly different between patients and controls (PZ0.19). Mean rates of VCC-measured RNFLT change were À 0.18 and À 0.37 lm per year in patients and controls, whereas the respective figures for ECC and OCT were À 0.13 and À 0.31 lm per year, and 0.04 and 0.61 lm per year. Mean rates of MD change were À 0.20 and 0.03 dB per year in patients and controls, respectively (P ¼ 0.01). Conclusion Rates of RNFLT change in glaucoma patients were not statistically different from control subjects for any modality. A significantly negative rate of MD change in patients suggests a genuine, continued deterioration in these patients not reflected by RNFLT changes.

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Reproducibility of Retinal Nerve Fiber Thickness Measurements Using the Stratus OCT in Normal and Glaucomatous Eyes

Cited by 264 publications

References 15 publications

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

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