Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomograph

Garas, Anita; Vargha, P.; Holló, Gábor

doi:10.1016/j.ophtha.2009.08.039

Cited by 156 publications

(154 citation statements)

References 30 publications

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“…Ganglion cell complex thickness in AMD E Yenice et al there is no available literature that investigated ganglion cell complex thickness with the SD-OCT in this patient group. 13,15 In a study, which was performed histopathological manner in AMD donors, GCL and photoreceptor topography was measured and GCL neurons survival level and relationship between photoreceptor loss was examined in the same eyes. These study findings were 47% loss of GCL neurons in end-stage cases of exudative AMD (EAMD) but preservation of GCL neurons in NEAMD.…”

Section: Discussionmentioning

confidence: 99%

Ganglion cell complex thickness in nonexudative age-related macular degeneration

Yenice

Şengün

Demirok

et al. 2015

Eye

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Purpose To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD). Methods Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 28 age-matched healthy subjects were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT were obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. GCC thickness was evaluated automatically as the average, minimum, temporal superior, superior, nasal superior, nasal inferior, inferior, and temporal-inferior segments by SD-OCT and parameters were compared between groups. Results The mean age was 68.7 ± 8.73 years in patient group, and 61.51 ± 5.66 years in control group. There were no significant differences in mean age, gender distribution, intraocular pressure, and sferic equivalent at imaging between the groups (P40.05). The mean (± SD) GCC thicknesses were as follows; average 71.53 ±16.53 μm, minumum 62.36 ± 21.51 μm, temporal superior 72.23 ± 14.60 μm, superior 72.76 ± 20.40 μm, nasal superior 72.31 ± 20.13 μm, nasal inferior 69.74 ± 20.51 μm, inferior 69.38 ± 19.03 μm, and temporal-inferior 73.12 ± 15.44 μm in patient group. Corresponding values in control group were 81.46 ± 4.90 μm, 78.66 ± 6.00 μm, 81.51 ± 4.66 μm, 82.94 ± 5.14 μm, 81.79 ± 5.86 μm, 80.94 ± 6.18 μm, 80.14 ± 6.30 μm, and 81.75 ± 5.26 μm, respectively. There were significant differences between two groups in each segments (Mann-Whitney U-test, Po0.05). Conclusion The average GCC thickness values (in all segments) of NEAMD patients were lower than control group. NEAMD, which is considered as a disease of outer layers of retina, may be accompanied with a decrease of ganglion cell thickness, so inner layers of retina may be affected.

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Section: Discussionmentioning

confidence: 99%

Ganglion cell complex thickness in nonexudative age-related macular degeneration

Yenice

Şengün

Demirok

et al. 2015

Eye

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“…The working principle of the device has been described in detail elsewhere. [1][2][3][4] In brief, the RTVue-OCT employs a near-infrared lightsource centred at 840 nm, with a 50 nm bandwidth. The normative database for diagnostic classification consists of 861 healthy eyes of mixed ethnicity subjects, with ages ranging between 19 and 82 years.…”

Section: Fourier Domain Octmentioning

confidence: 99%

“…For RNFLT, GCC and ONH measurements the standard glaucoma protocol was used. 2 This includes a 3D optic disc scan for the definition of the disc margin on the basis of the computer-assisted determination of retinal pigment epithelium endpoints, an ONH scan to measure the optic disc parameters and RNFLT within an area of diameter 4 mm, centred on the pre-defined disc, and the standard GCC scan. Each ONH scan consists of 12 radial lines and six concentric rings, which are used to create an RNFLT map.…”

Section: Fourier Domain Octmentioning

confidence: 99%

“…[1][2][3][4][5][6] In various studies, [7][8][9][10][11][12] the sensitivity and specificity of the Stratus OCT in detecting early glaucoma has been found to be only moderate to high. OCT instruments employing the Fourier-domain technology have significantly higher resolution and scan speed, improved image segmentation and better measurement reproducibility compared with the timeFdomain OCT. [1][2][3][4][5][6] Though the technology is new, information on the diagnostic accuracy of the different Fourier-domain OCT instruments to detect glaucoma of different severity, is increasing. 5,6,[13][14][15][16][17][18][19][20][21] The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is one of the new commercially available Fourier-domain OCT instruments.…”

Section: Introductionmentioning

confidence: 99%

“…5,6,[13][14][15][16][17][18][19][20][21] The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is one of the new commercially available Fourier-domain OCT instruments. [1][2][3][4][17][18][19][20][21] Its axial resolution is approximately 5 mm and the scan speed is 26 000 A-scans per second. Thus the speed is 65 times higher than that of the Stratus OCT system, and the resolution is about twice as good as such time-domain OCT instruments.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Garas

Vargha

Holló

2010

Eye

138

107

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Purpose To evaluate the diagnostic accuracy of retinal nerve fibre layer thickness (RNFLT), ganglion cell complex (GCC), and optic disc measurements made with the RTVue-100 Fourier-domain optical coherence tomography (OCT) to detect glaucoma in a Caucasian referral population. Methods One randomly selected eye of 286 Caucasian patients (93 healthy, 36 ocular hypertensive, 46 preperimetric glaucoma, and 111 perimetric glaucoma eyes) was evaluated. Results Using the software-provided classification, for the total population sensitivity did not exceed 73.6% for the optic nerve head parameters, and 62.7% for the other parameters. Specificity was high (94.6-100%) for most RNFLT and GCC parameters, but low (72.0-76.3%) for the optic disc parameters. Positive predictive value varied between 98.1 and 100% for the main RNFLT parameters, 92.6 and 100% for the 16 RNFLT sectors, 92.4 and 99.0% for the GCC parameters, but did not exceed 86.3% for any of the optic disc parameters. Positive likelihood ratio (PLR) was higher than 10 for average, inferior and superior RNFLT (25.5 to infinite), 12 of the 16 RNFLT sectors (12.6 to infinite), and three of the four GCC parameters (40.0 to 48.6). No optic disc parameter had a PLR higher than 3.0. Conclusions RNFLT and GCC parameters of the RTVue-100 Fourier-domain OCT showed moderate sensitive but high specificity, positive predictive value and PLR for detection of glaucoma. The optic disc parameters had lower diagnostic accuracy than the RNFLT and GCC parameters.

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Utilizing Optical Coherence Tomography in Glaucoma Management

Fox

Reznik

Medeiros

2020

Essentials in Ophthalmology

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Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomograph

Cited by 156 publications

References 30 publications

Ganglion cell complex thickness in nonexudative age-related macular degeneration

Ganglion cell complex thickness in nonexudative age-related macular degeneration

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Utilizing Optical Coherence Tomography in Glaucoma Management

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