Reproducibility of Spectral-Domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

Suh, Min Hee; Yoo, Byeong Wook; Park, Ki Ho; Kim, Hyun‐Joong; Kim, Hee Chan

doi:10.1097/ijg.0000000000000143

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…In adults, the effect of disease severity in glaucoma on reproducibility has been contradictory. Studies using Cirrus OCT on normal and glaucoma eyes have shown both similar [ 23 ] and worse [ 24 ] reproducibility in the affected eyes. Whether, the intra-and inter variations are affected in children with optic nerve diseases has to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

Larsson¹,

Molnar²,

Holmström³

2018

BMC Ophthalmol

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BackgroundThe aim was, first, to collect normative data of the optic nerve head and the peripapillary retinal nerve fibre layer (RNFL) thickness assessed with Cirrus SD-OCT, in healthy children in a population-based study; second, using these data, to examine repeatability, reproducibility and the interocular difference.MethodsOne-hundred and ten eyes from 57 children aged 6–15 born at term, were examined. Best-corrected visual acuity and refraction were assessed. Both eyes were examined and the interocular difference was calculated. Repeatability was calculated by one examiner performing three assessments. Thereafter, a second examiner repeated the assessments to calculate reproducibility.ResultsMean RNFL thickness was 99.2 (SD 8.8) μm, mean disc area 1.89 (SD 0.37) mm2 and mean rim area 1.52 (SD 0.26) mm2. No significant correlations with age, gender or refraction were found. Repeatability and reproducibility were good overall. There was interocular symmetry between the eyes.ConclusionsNormal values for optic nerve head and RNFL thickness assessed with Cirrus SD-OCT were gathered to obtain a normal material in children. High repeatability and reproducibility indicated reliability of assessments performed by different examiners on different occasions. Overall, good correlation between right and left eyes was found.

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Section: Discussionmentioning

confidence: 99%

Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

Larsson¹,

Molnar²,

Holmström³

2018

BMC Ophthalmol

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“…Abnormal thickness of the macula and the RNFL in the optic disc is associated with numerous ocular disease states. Thinning of the RNFL is a characteristic trait of glaucoma 12 , 13 and changes in RNFL thickness are evident in patients with myopia. 14 , 15 Furthermore, RNFL thickness is increased in individuals with amblyopia, 16 and the thickness of the GCL in the macula is increased in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Retinal changes following rapid ascent to a high-altitude environment

Tian

Jia

et al. 2017

Eye

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PurposeTo determine what impact rapid ascension to a high-altitude environment has on the retina with the aim of preventing and treating high-altitude oculopathy.Patients and methodsParticipants in the study were members of the Chinese military assigned to the high-altitude environment of the Tibetan plateau. Ninety-one participants were enrolled in the study. Optical coherence tomography was used to measure the thickness of retina-related indicators. Measurements were taken before and after exposure to the high-altitude environment and upon return to the baseline altitude.ResultsFollowing exposure to the high-altitude environment in Tibet, there was a significant increase in retinal nerve fiber layer (RNFL) thickness in the temporal and nasal quadrants of the optic disc, whilst a significant decrease in RNFL thickness in the inferior optic disc was also observed. A significant increase in RNFL thickness in the superior and inferior macula was also evident, along with a significant increase in the ganglion cell layer thickness in the superior macula. Upon return to the baseline altitude, all measurements returned to baseline levels except for the RNFL of the inferior macula, which was significantly thicker. Pathological changes were also documented in the eyes of nine participants upon returning to baseline altitude, including ischemic optic neuropathy, myopia, and cortical amaurosis.ConclusionsThe high-altitude environment can have a negative impact on the health of the retina and may contribute to the incidence of various eye diseases. This study deepens the understanding of what impact a high-altitude environment has on retina and provides reliable data for blindness prevention and treatment.

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“…Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging technique that allows for in vivo quantification of the retinal nerve fiber layer (RNFL) and the optic disc features, thereby enabling determination of both the presence and progression of glaucomatous structural damage [ 13 , 14 ]. The measurement of RNFL thickness differences in follow-up visits is very important, especially for detecting the progression of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Retinoschisis in Glaucoma Patients

Bayraktar

Cebeci

Kabaalioglu

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate peripapillary retinoschisis and its effect on retinal nerve fiber layer (RNFL) thickness measurements by using spectral-domain optical coherence tomography (SD-OCT) in glaucomatous eyes. Methods. Circumpapillary RNFL (cpRNFL) B-scan images of 940 glaucoma patients (Group 1) and 801 glaucoma-suspect patients (Group 2) obtained by SD-OCT were reviewed. The structural and clinical characteristics of the retinoschisis were investigated. The RNFL thickness measurements taken at the time of retinoschisis diagnosis and at the follow-up visits were also compared. Results. Twenty-nine retinoschisis areas were found in 26 of the 940 glaucoma patients (3.1%) in Group 1 and seven areas were found in 801 patients (0.87%) in Group 2. In glaucomatous eyes, the retinoschisis was attached to the optic disc and overlapped with the RNFL defect. At the time of retinoschisis, the RNFL thickness was statistically greater in the inferior temporal quadrant when compared with the follow-up scans (p < 0.001). No macular involvement or retinal detachment was observed. Conclusion. The present study investigated 33 peripapillary retinoschisis patients. Increase in RNFL thickness measurements was observed at the time of retinoschisis. It is important to examine the cpRNFL B-scan images of glaucoma patients so that the RNFL thickness is not overestimated.

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Reproducibility of Spectral-Domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

Cited by 9 publications

References 32 publications

Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

Retinal changes following rapid ascent to a high-altitude environment

Peripapillary Retinoschisis in Glaucoma Patients

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