Reproducibility of ¹⁹F‐MR ventilation imaging in healthy volunteers

Abstract

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Functional lung imaging using novel and emerging MRI techniques

“…Furthermore, preliminary data suggests a strong correlation between 19 F-MRI VDP and FEV1 in a cohort of COPD subjects ( 217 ). Intra-and inter-session reproducibility has also been demonstrated ( 218 , 219 ).…”

Small Molecule Probes for 19F Magnetic Resonance Imaging

“…The search for alternative magnetic nuclei for imaging to compensate for the drawbacks of 1 H MRI has been conducted for decades. 19 F has been gradually realized and accepted as a promising complement to 1 H for MRI owing to its favorable properties, such as excellent sensitivity (∼90% of 1 H), high natural abundance (100%), broad range of chemical shifts (>350 ppm), and low biological distribution (<10 –6 M and only in bones and teeth). − These advantages allow for in vivo multiplex detection of low-concentration targets by 19 F MRI and rendering them quantitatively in “hot-spot” images with negligible background. − Furthermore, some substantial progress has been made in challenging pulmonary imaging with 19 F MRI. − It is noteworthy that some fluorinated compounds, such as perflubron (perfluorooctyl bromide, PFOB), perflexane (tetradecafluorohexane, C 6 F 14 ), and perflutren (octafluoropropane, C 3 F 8 ), have been approved for clinical use, which facilitates the popularization of 19 F MRI …”

Volume‐Controlled 19F MR Ventilation Imaging of Fluorinated Gas

“…Gutberlet et al showed the repeatability of dynamic washout parameters under free breathing within 2 weeks in a small cohort of COPD patients, 9 whereas Pippard et al showed the reproducibility of the static ventilation without patient repositioning in a large cohort of healthy participants. 14 Since parameters deduced from dynamic gas imaging strongly depend on the volume of inspired gas in relation to the total lung volume, variations of inspiratory gas volumes between different patients hinders intersubject comparisons. Furthermore, variations of inspiratory gas volumes within the gas wash-in procedure destabilize the fitting of monoexponential models for dynamic ventilation parameters.…”

“…To further the clinical translation of this technique, the stability of certain imaging markers has been investigated in the literature. Gutberlet et al showed the repeatability of dynamic washout parameters under free breathing within 2 weeks in a small cohort of COPD patients, 9 whereas Pippard et al showed the reproducibility of the static ventilation without patient repositioning in a large cohort of healthy participants 14 …”