Reproducibility of the study of placental vascularization by three-dimensional power Doppler

Mercé, Luis T.; Barco, María J.; Bau, Santiago

doi:10.1515/jpm.2004.043

Cited by 120 publications

(101 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, the increase in the number of vessels is followed by a progressive decrease in the vascular resistance, which contributes to the increase in perfusion and intraplacental flow (21) . The results of the present study are in agreement with those obtained by a Spanish group that has utilized the placental biopsy technique, in which the authors obtained ICC above 0.85 for the three indices, with best intraobserver reproducibility for the flow indices (FI and VFI) (4) . Recently, researchers evaluated the placental vascularization between the 12th and 40th gestational weeks, using the VOCAL method with manual delimitation of the whole external surface, and observed good intra-and interobserver reproducibility for the three indices, with FI presenting the highest ICC and the lowest difference between measurements (5) .…”

Section: Discussionsupporting

confidence: 92%

“…The 3D power Doppler vascular indices have been applied in the evaluation of the placental vascularization at the second and third gestational trimesters, presenting a proven intra-and interobserver reproducibility (4,5) . Recently, a good intraobserver reproducibility was also demonstrated for vascular indices of the intervillous and uteroplacental circulation between the 5th and 12th gestational weeks (6) ; however, no description is found about their reproducibility in the evaluation of the embryo's vascularization at the first gestational trimester.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reprodutibilidade interobservador dos índices vasculares do Doppler de amplitude tridimensional do embrião entre 7 e 10 semanas e 6 dias de gestação

et al. 2010

View full text Add to dashboard Cite

OBJETIVO: Avaliar a reprodutibilidade interobservador dos índices de vascularização do Doppler de amplitude tridimensional (Doppler de amplitude 3D) no primeiro trimestre de gestação. MATERIAIS E MÉTODOS: Realizou-se estudo de reprodutibilidade com 32 gestantes normais entre 7 e 10 semanas e 6 dias. Para o cálculo do volume tridimensional dos embriões utilizou-se o método VOCAL (Virtual Organ Computer-aided AnaLysis) com ângulo de rotação de 12°. Em seguida obtiveram-se, automaticamente, os três índices vasculares do Doppler de amplitude 3D: índice de vascularização (VI), índice de fluxo (FI) e índice de vascularização e fluxo (VFI). Para o cálculo da variabilidade interobservador, um examinador realizou uma segunda medida dos 32 embriões e um segundo examinador realizou uma terceira medida dos mesmos volumes, ambos desconhecendo os resultados do outro. Utilizaram-se, para análise estatística, o coeficiente de correlação intraclasse (CCI) e gráficos de Bland-Altman. RESULTADOS: Observou-se boa reprodutibilidade interobservador dos três índices vasculares. O VI apresentou CCI = 0,9 e média da diferença = -1,1; o FI apresentou CCI = 0,9 e média da diferença = -0,5; e o VFI apresentou CCI = 0,9 e média da diferença = -1,1. CONCLUSÃO: Os índices vasculares do Doppler de amplitude 3D do embrião no primeiro trimestre de gestação foram altamente reprodutíveis, em especial o FI.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Reprodutibilidade interobservador dos índices vasculares do Doppler de amplitude tridimensional do embrião entre 7 e 10 semanas e 6 dias de gestação

et al. 2010

View full text Add to dashboard Cite

show abstract

“…tion of placental volume and the vascularization indices derived therefrom in detail. [7][8][9] These studies varied in their design and inclusion criteria and may not be generalizable to all study populations because they were performed by pioneers in the area of study using earlier techniques for 3D volume acquisition. More current and detailed evaluation is needed before adopting these in routine assessment of normal and complicated pregnancies.…”

Section: T Articlementioning

confidence: 99%

Reproducibility of Placental Volume and Vasculature Indices Obtained by 3-Dimensional Power Doppler Sonography

Huster

Haas

Schoenborn

et al. 2010

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objective. The purpose of this study was to evaluate the reproducibility of 3‐dimensional (3D) power Doppler assessment of placental volumes and vascularization before adopting these in routine evaluation of normal and complicated pregnancies. Methods. A prospective study was performed on 30 normal singleton pregnancies from 11 to 14 weeks. To evaluate placental vascularization, 3D power Doppler sonography was applied to obtain a placental volume, and the volume acquired was analyzed using virtual organ computer‐aided analysis. Two consecutive measurements were taken from each patient by two observers blinded to each other's and the individual's previous measurement. This yielded a total of 60 data set pairs. The placental volume, vascularization index, flow index, and vascularization‐flow index (VFI) were calculated. Normal distribution of the data was confirmed with the Kolmogorov‐Smirnov test. Intraobserver and interobserver correlations were evaluated. Bland‐Altman plots and statistics were used to compare the 95% limits of agreement between measurements. Results. All 3D power Doppler placental volumes and vascular indices showed intraobserver correlations of 0.80 or higher. Similar excellent interobserver correlations were seen for all indices with the exception of the VFI, which showed a lower but acceptable correlation. The Bland‐Altman analyses indicated good reproducibility of the evaluated placental indices. Conclusions. Our findings provide validation of the technique, showing good reproducibility of the 3D power Doppler parameters when applied to studies of the placental volume and vascular tree.

show abstract

“…The Food Drug Agency approved initially higher doses [2]. Additional the clinical evidence based regimens use low doses of mifepristone (200 mg) and have similar efficacy with a shorter timing between mifepristone and misoprostol dosing to allow women more flexibility and the FDA released the new label for mifepristone recommending the 200-mg dose based on this vast history of clinical efficacy [6,7].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in Early Gestation: Pilot Study

Pellicer-Iborra¹,

Herraiz²,

Morales³

et al. 2017

Gynecol Obstet

View full text Add to dashboard Cite

Mifepristone (RU486) it is known as an effective abortifacient and postcoital contraceptive method, whose mechanism is not yet known. We carried on a pilot study with the aim of determining the effect that Mifepristone could have in utero-placental vascular compartment during the first trimester of pregnancy compared with placebo. This is a randomized, double-blind, placebo-controlled research. We randomly assigned to two groups patients requesting pregnancy termination with a gestational age between 9th and 11st weeks: Group A receiving placebo and Group B receiving RU. With transvaginal ultrasound tridimensional probe we measured at an initial time (t1) and then 4 hours after administration of Mifepristone or placebo (t2) Doppler parameters: uterine arteries mean Resistance Index, spiral arteries Resistance Index, intervillous flow, umbilical Resistance Index and tridimensional vascular settings and the placental volume. We observed how Mifepristone shows an immediate selective hemodynamic effect in trophoblastic tissue in the first hours of administration. A significant decrease in spiral arteries pulsatility index was demonstrated, without modifying uterine maternal and fetal territories or the other studied parameters. Angiopower 3D evaluation of the interface maternal fetal is complex and encourages to carry further investigations carry further investigations.

show abstract

Reproducibility of the study of placental vascularization by three-dimensional power Doppler

Cited by 120 publications

References 31 publications

Reprodutibilidade interobservador dos índices vasculares do Doppler de amplitude tridimensional do embrião entre 7 e 10 semanas e 6 dias de gestação

Reprodutibilidade interobservador dos índices vasculares do Doppler de amplitude tridimensional do embrião entre 7 e 10 semanas e 6 dias de gestação

Reproducibility of Placental Volume and Vasculature Indices Obtained by 3-Dimensional Power Doppler Sonography

Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in Early Gestation: Pilot Study

Contact Info

Product

Resources

About