Reproducible Diuresis and Chloruresis for Bioassay of Antidiuretic Activity

Ham, George C.

doi:10.3181/00379727-53-14254

Cited by 15 publications

(3 citation statements)

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“…CO. The antidiuretic activity of urines of six patients was measured by a bio-assay technic (14) damage; and IV. Patients with low serum albumin levels without edema or ascites.…”

Section: Methodsmentioning

confidence: 99%

The Use of Concentrated Human Serum Albumin in the Treatment of Cirrhosis of the Liver 1

Kunkel¹,

Labby²,

Ahrens³

et al. 1948

J. Clin. Invest.

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The formation of ascites in patients with cirrhosis of the liver probably depends on at least three factors: (1) hypoalbuminemia, (2) portal hypertension, and (3) increased amounts of circulating antidiuretic substance. The relative importance of these factors varies with the individual patients. Although the formation and disappearance of ascites do not correlate perfectly with levels of serum albumin in all patients, in the majority of cases the two findings are coincident and apparently related (1, 2). The use of concentrated human serum albumin in these patients for its osmotic effect would be expected to cause a diuresis. The extent to which this diuresis is produced would depend in large part upon the relative importance of the various factors of ascites production, being most marked in those patients in whom hypoalbuminemia is most specifically at fault.The observations of Janeway (3) and Thorn (4) and their co-workers in patients with liver disease demonstrated that the albumin level of the serum could be raised to normal by repeated injections of albumin. Certain of their patients showed a loss of edema and ascites but the oncotic effects were disappointing in their experience.

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“…CO. The antidiuretic activity of urines of six patients was measured by a bio-assay technic (14) damage; and IV. Patients with low serum albumin levels without edema or ascites.…”

Section: Methodsmentioning

confidence: 99%

The Use of Concentrated Human Serum Albumin in the Treatment of Cirrhosis of the Liver 1

Kunkel¹,

Labby²,

Ahrens³

et al. 1948

J. Clin. Invest.

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show abstract

“…The multiplicity of methods of Pitressin or ADS assay (18)(19)(20)(21)(22)(23)(24) attests to the technical difficulties and lack of uniformity of results encountered in such procedures; some of these assay procedures have been summarized well by Ham (23).…”

Section: Introductionmentioning

confidence: 99%

“…An analysis of the pertinent literature (23,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) indicates that the lack of agreement on this problem may be ascribed to several experimental variables: (a) types of extracts of the posterior pituitary lobe that have been administered; (b) dosages used; (c) routes of administration; (d) species of experimental test organism; (e) methods of expressing the changes in excretion of electrolytes following the administration of posterior pituitary fractions, either in terms of concentration (mEq./l) or in absolute quantity per unit time (mEq./min. ).…”

Section: Introductionmentioning

confidence: 99%