Reproduction as a window for health in men

Belladelli, Federico; Muncey, Wade

doi:10.1016/j.fertnstert.2023.01.014

Cited by 8 publications

(6 citation statements)

References 112 publications

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“…Previous studies have suggested that MI may increase the risk of developing type 2 diabetes. 6,7,[9][10][11]22,23 A few studies have also investigated whether diabetes may contribute to the development of MI. One study of 27 diabetic and 29 non-diabetic maleidentified patients found few differences in semen parameters between the two groups, with the exception of volume.…”

Section: Discussionmentioning

confidence: 99%

“…5 There has also been growing consensus that MI could be a marker of current and future health. [6][7][8] Indeed, numerous retrospective and prospective case-control and cohort studies have investigated MI in the context of numerous health outcomes, including whether MI is associated with an increased incidence of diabetes, cardiovascular disease, and autoimmune disease, as well as whether conditions such as chronic kidney disease could be a risk factor for MI. [9][10][11][12][13] However, there have been no prior studies leveraging a data-driven approach for identifying the full breadth of potential comorbidities that are risk factors for or adverse health outcomes of MI.…”

Section: Introductionmentioning

confidence: 99%

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Leveraging Electronic Medical Records from Two Hospital Systems Identifies Male Infertility Associated Comorbidities Across Time

Sirota,

Woldemariam,

Xie

et al. 2023

Preprint

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Male infertility (MI) accounts for at least 30% of infertility etiology, yet the full breadth of potential MI risk factors and adverse health outcomes has not been explored. Here, we use electronic medical records (EMRs) from the University of California (UC) and Stanford to implement a data-driven case-control study to identify MI-associated comorbidities. We identified 6,531 and 5,551 MI patients at UC and Stanford, respectively, as well as 8,353 and 2,464 vasectomy control patients at UC and Stanford, respectively. We used temporally-stratified logistic regression analyses to identify MI-associated comorbidities before or after 6 months after a patient’s first MI diagnosis or vasectomy-related record. We found 15 and 2 diagnoses positively associated with MI before and after the 6-month cutoff across both hospital systems and all analyses, respectively, including less expected comorbidities such as hypothyroidism and type 2 diabetes. Our findings can set the groundwork for future studies to clarify the relationship between less expected comorbidities and MI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leveraging Electronic Medical Records from Two Hospital Systems Identifies Male Infertility Associated Comorbidities Across Time

Sirota,

Woldemariam,

Xie

et al. 2023

Preprint

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“…There is a surge of interest in male reproductive health (MRH) fueled by emerging evidence of globally declining sperm counts ( Levine et al , 2023 ), associations between poor MRH and somatic disorders ( Latif et al , 2017 ; Belladelli et al , 2023 ), and the impact of paternal morbidities on the next generation ( Yu et al , 2023 ), among others. As with any emerging health concern, there is a need for a rational approach to identify the important questions, gather intelligence, and use the data to formulate evidence-based actions ( Kimmins et al , 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Current global status of male reproductive health

De Jonge,

Barratt,

Aitken

et al. 2024

Human Reproduction Open

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BACKGROUND The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identify critical questions, collect pertinent information, and utilize this data to develop evidence-based strategies. The methods for addressing these questions and the pathways towards their answers will inevitably vary based on the variations in cultural, geopolitical, and health-related contexts. To address these issues, a conjoint ESHRE and Male Reproductive Health Initiative (MRHI) Campus workshop was convened. OBJECTIVE AND RATIONALE The three objectives were: first, to assess the current state of MRH around the world; second, to identify some of the key gaps in knowledge; and, third, to examine how MRH stakeholders can collaboratively generate intelligent and effective paths forward. SEARCH METHODS Each expert reviewed and summarized the current literature that was subsequently used to provide a comprehensive overview of challenges related to MRH. OUTCOMES This narrative report is an overview of the data, opinions and arguments presented during the workshop. A number of outcomes are presented and can be summarized by the following overarching themes: MRH is a serious global issue and there is a plethora of gaps in our understanding; there is a need for widespread international collaborative networks to undertake multidisciplinary research into fundamental issues, such as lifestyle/environmental exposure studies, and high quality clincial trials; and there is an urgent requirement for effective strategies to educate young people and the general public to safeguard and improve MRH across diverse population demographics and resources. LIMITATIONS, REASONS FOR CAUTION This was a workshop where worldwide leading experts from a wide range of disciplines presented and discussed the evidence regarding challenges related to MRH. Whilst each expert summarised the current literature and placed it in context, the data in a number of areas is limited and/or sparse. Equally, important areas for consideration may have been missed. Moreover, there are clear gaps in our knowledge base, which makes some conclusions necessarily speculative and warranting of further study. WIDER IMPLICATIONS Poor MRH is a global issue that suffers from low awareness among the public, patients and heathcare professionals. Addressing this will require a coordinated multidisciplinary approach. Addressing the significant number of knowledge gaps will require policy makers prioritizing MRH and its funding. STUDY FUNDING/COMPETING INTEREST(S) The authors extend their gratitude to ESHRE for financial support of the Budapest Campus Workshop. PB is the Director of the not-for-profit organization Global Action on Men’s Health and receives fees and expenses for his work, (which includes the preparation of this manuscript. Conflicts of interest: CJDJ, CLRB, RAA, PB, MPC, MLE, NG, NJ, CK, AAP, MKO, SR-H, MHV-L: ESHRE Campus Workshop 2022 (Travel support—personal). CJDJ: Cambridge University Press (book royalties—personal). ESHRE Annual Meeting 2022 and Yale University Panel Meeting 2023 (Travel support—personal). CLRB: Ferring and IBSA (Lecture), RBMO editor (Honorarium to support travel etc), ExSeed and ExScentia (University of Dundee), Bill & Melinda Gates Foundation (for research on contraception). MPC: Previously received funding from pharmaceutical companies for health economic research. The funding was not in relation to this work and had no bearing on the contents of this work. No funding from other sources has been provided in relation to this work (Funding was provided to his company Global Market Access Solutions. MLE: Advisor to Ro, Doveras, Next, Hannah, Sandstone CK: European Academy of Andrology (Past president UNPAID), SK: CEO of His Turn, a male fertility Diagnostic and Therapeutic company (No payments or profits to date). RIM: www.healthymale.org.au (Australian Government funded not for profit in men’s health sector (Employed as Medical Director 0.2 FET), Monash IVF Pty Ltd (Equity holder). NJ: Merck (consulting fees), Gedeon Richter (honoraria). SR-H: ESHRE (Travel reimbursements). CN: LLC (Nursing educator); COMMIT (Core Outcomes Measures for Infertility Trials) Advisor, meeting attendee and co-author; COMMA (Core Outcomes in Menopause) Meeting attendee and co-author; International Federation of Gynecology and Obstetrics (FIGO) Delegate Letters and Sciences; ReproNovo, Advisory board; American Board of Urology Examiner; American Urological Association Journal subsection editor, committee member, guidelines co-author Ferring Scientific trial NexHand Chief Technology Officer, stock ownership Posterity Health Board member, stock ownership. AP: Economic and Social Research Council (A collaborator on research grant number ES/W001381/1). Member of an advisory committee for Merck Serono (November 2022), Member of an advisory board for Exceed Health, Speaker fees for educational events organized by Mealis Group; Chairman of the Cryos External Scientific Advisory Committee: All fees associated with this are paid to his former employer The University of Sheffield. Trustee of the Progress Educational Trust (Unpaid). MKO’B: National Health and Medical Research Council and Australian Research Council (Funding for research of the topic of male fertility), Bill and Melinda Gates Foundation (Funding aimed at the development of male gamete-based contraception), Medical Research Future Fund (Funding aimed at defining the long-term consequences of male infertility). MHV-L: Department of Sexual and Reproductive Health and Research (SRH)/Human Reproduction Programme (HRP) Research Project Panel RP2/WHO Review Member; MRHI (Core Group Member), COMMIT (member) EGOI (Member); Human Reproduction (Editor), Fertility and Sterility (Editor), AndroLATAM (Founder and Coordinator).

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“…Recent data clearly indicate that impaired semen quality may also be a marker of increased risk of common non-contagious diseases. 8 Thus, in the future, examining male semen may not only be relevant for reproductive clinicians and researchers but could be used as a tool in general medical practice. These additional applications not only increase the need for improving the quality of analysis, but also stress the importance of accurate reports of basic semen test results…”

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confidence: 99%

“…It is also used in epidemiological and other research studies assessing environmental, lifestyle, and occupational exposures potentially hazardous to male reproductive function. Recent data clearly indicate that impaired semen quality may also be a marker of increased risk of common non‐contagious diseases 8 . Thus, in the future, examining male semen may not only be relevant for reproductive clinicians and researchers but could be used as a tool in general medical practice.…”

mentioning

confidence: 99%