Reproduction expérimentale de la méningo-encéphalomyélite du cheval par l’arbovirus West Nile. III. — Relations entre la virologie, la sérologie, et l’évolution anatomo-clinique. Conséquences épidémiologiques et prophylactiques

Joubert, Louis; Oudar, J; Hannoun, C.; Chippaux, A.

doi:10.4267/2042/66261

Cited by 13 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Horses, as well as humans, are generally considered to be dead-end hosts of WN infection; however, little is known about the duration and magnitude of viremia. Experimental infections in horses and donkeys in Egypt (25) and in France (30,31) showed undetectable or low viremia of short duration. However, these experiments were conducted in different conditions with different WN strains; therefore, it is difficult to extrapolate from these results.…”

Section: Discussionmentioning

confidence: 98%

West Nile Outbreak in Horses in Southern France, 2000: The Return after 35 Years

Murgue

Murri

Zientara

et al. 2001

Emerg. Infect. Dis.

185

View full text Add to dashboard Cite

On September 6, 2000, two cases of equine encephalitis caused by West Nile (WN) virus were reported in southern France (Hérault Province), near Camargue National Park, where a WN outbreak occurred in 1962. Through November 30, 76 cases were laboratory confirmed among 131 equines with neurologic disorders. The last confirmed case was on November 3, 2000. All but three cases were located in a region nicknamed "la petite Camargue," which has several large marshes, numerous colonies of migratory and resident birds, and large mosquito populations. No human case has been confirmed among clinically suspected patients, nor have abnormal deaths of birds been reported. A serosurvey has been undertaken in horses in the infected area, and other studies are in progress.

show abstract

Section: Discussionmentioning

confidence: 98%

West Nile Outbreak in Horses in Southern France, 2000: The Return after 35 Years

Murgue

Murri

Zientara

et al. 2001

Emerg. Infect. Dis.

185

View full text Add to dashboard Cite

show abstract

“…According to the authors, their neuroinvasive potential was found not to be influenced by the source of the virus (mosquito, mammal, bird) or by its passage history. Individual factors of receptivity are also thought to be of major importance for the evolution and clinical expression of WNF (Joubert et al., 1971; Beasley et al., 2002). Indeed, several authors (Glass et al., 2005; Brault et al., 2007; Lim et al., 2009) demonstrated that variations in certain loci of the host’s genome influenced susceptibility to and clinical presentation of WNV infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical Diagnosis of West Nile Fever in Equids by Classification and Regression Tree (CART) Analysis and Comparative Study of Clinical Appearance in Three European Countries

Porter

Leblond²,

Lecollinet

et al. 2011

Transboundary and Emerging Diseases

View full text Add to dashboard Cite

This retrospective study describes risk/protection factors for the development of clinical West Nile Fever (WNF) in equids, compares clinical presentation in three European countries, France, Italy and Hungary, and creates classification and regression trees (CART) to facilitate clinical diagnosis. The peak of WNF occurrence was observed in September whatever the country. A significant difference between Italy and France was observed in the delay between initial clinical signs and veterinary consultation. No clinical sign was significantly associated with WNF. Despite similar clinical presentations in the three countries, occurrence of hyperthermia was more frequently reported in France. Classification and regression tree demonstrated the major importance of geographical locality and month to reach a diagnosis and emphasized differences in predominant clinical signs depending on the period of detection of the suspected case (epizootic or not). However, definite diagnosis requires specific serological tests. Centralized reporting system and time-space risk mapping should be promoted in every country.

show abstract

“…The development of the infection depends upon a series of conditions, such as the vector biology and the host's general health status. Transmission from incidental hosts seems unlikely, since viraemia is of short duration (Joubert et al 1971). The onset of clinical signs is usually abrupt, generally occurring after the development of viraemia and the CNS localisation of the virus.…”

Section: Discussionmentioning

confidence: 99%

Clinical and neuropathological features of West Nile virus equine encephalomyelitis in Italy

Cantile

Guardo

Eleni

et al. 2000

Equine Veterinary Journal

171

163

View full text Add to dashboard Cite

West Nile (WN) virus infection is a mosquito-borne flavivirosis endemic in Africa and Asia. Clinical disease is usually rare and mild and only in a few cases the infection causes encephalomyelitis in horses, fever and meningoencephalitis in man. We report here the clinical and pathological findings in an epidemic of the disease involving 14 horses from Tuscany, Italy. All cases were observed from August to October 1998. Affected horses showed ataxia, weakness paresis of the hindlimbs and, in 6 cases, there was paraparesis progressing to tetraplegia and recumbency within 2 to 9 days. Eight animals recovered without any important consequences. Serological investigations revealed positivity to WN virus in all the 14 horses and the agent was isolated from the cerebellum and spinal cord of an affected horse. Postmortem examination was carried out on 6 horses. The neuropathological pattern was that of a mild to moderate, nonsuppurative polioencephalomyelitis with constant involvement of the ventral horns of the thoracic and lumbar spinal cord, where focal gliosis and haemorrhage were also apparent in some cases. Differential diagnoses with other equine viral encephalomyelitides are discussed. Climatological and environmental characteristics of the geographic area in which the outbreaks occurred suggest the existence of suitable conditions for the development of the disease. This is the first report of WN virus equine encephalomyelitis in Italy.

show abstract

Reproduction expérimentale de la méningo-encéphalomyélite du cheval par l’arbovirus West Nile. III. — Relations entre la virologie, la sérologie, et l’évolution anatomo-clinique. Conséquences épidémiologiques et prophylactiques

Cited by 13 publications

References 0 publications

West Nile Outbreak in Horses in Southern France, 2000: The Return after 35 Years

West Nile Outbreak in Horses in Southern France, 2000: The Return after 35 Years

Clinical Diagnosis of West Nile Fever in Equids by Classification and Regression Tree (CART) Analysis and Comparative Study of Clinical Appearance in Three European Countries

Clinical and neuropathological features of West Nile virus equine encephalomyelitis in Italy

Contact Info

Product

Resources

About