REPRODUCTION STUDIES OF CARBOPLATIN(II) : Intravenous administration to rats during the period of fetal organogenesis

Kai, Shuichi; Kohmura, Hisashi; Ishikawa, Katsumi; Takeuchi, Yukako; Ohta, Satoshi; Kuroyanagi, Kohji; Kadota, Toshihito; Kawano, Shigeo; Chikazawa, Hirotaka; Kondo, Hiroshi; Sakai, Atsuko; Takahashi, Norimitsu

doi:10.2131/jts.13.supplementii_35

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…Carboplatin was also found to be associated with inhibition of fetal growth and reduced brain weight but did not affect postnatal differentiations, early behavioural development, learning ability, motor activity, or emotional development when administered to rats during the period of fetal organogenesis 69 . Paclitaxel administration in rats during early pregnancy can cause craniofacial malformations, diaphragmatic hernias, and kidney and cardiovascular system defects 70 . In advanced pregnancy, paclitaxel did not affect body weight, learning ability, and memory or spontaneous motor activity 71 …”

Section: Discussionmentioning

confidence: 99%

Epithelial ovarian cancer in pregnancy: a review of the literature

Palmer

Vatish

Tidy

2009

BJOG

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Maternal epithelial ovarian cancer (EOC) is rare, and consequently, management strategies remain unclear due to the low incidence and paucity of reported data. Management depends on gestation, disease stage, future fertility desires, and the mother's wishes to continue pregnancy. Forty-one cases of maternal EOC were identified in the literature. Reporting of clinicopathological variables, treatment regimens, and follow up varied markedly. There are currently no definitive guidelines regarding the management of maternal EOC. Case reporting should contain detailed information on clinicopathological variables, treatment regimens, and maternal and neonatal outcomes. Data centralisation may be beneficial in identifying optimal management strategies in these rare tumours.

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Section: Discussionmentioning

confidence: 99%

Epithelial ovarian cancer in pregnancy: a review of the literature

Palmer

Vatish

Tidy

2009

BJOG

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“…In these rodents no teratogenic effects were detected when carboplatin was administered from day 7 to 17 of gestation. However, treatment in early pregnancy during organogenisis induced intra-uterine death and congenital malformations like gastroschisis, dilatation of cerebral ventricles, or skeletal malformations [42][43][44][45]. Therefore, cytotoxic treatment should be reserved to the later stages of pregnancy and abortion has to be considered in patients scheduled for chemotherapy during organogensis.…”

Section: Chemotherapy During Pregnancymentioning

confidence: 99%

Adnexal Masses in Pregnancy

et al. 2003

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With the widespread use of routine abdominal ultrasound examination during pregnancy, adnexal masses are observed with increasing frequency. Most patients are clinically asymptomatic at the time of presentation, and most of the adnexal masses detected during early pregnancy disappear during the first 16 weeks of pregnancy. Ovarian tumors are estimated to occur in about 1 in 1,000 pregnancies and of these 3% are malignant. Here we present an overview about frequency, diagnostic procedures and pathological characteristics of these ovarian tumors. Moreover, current modalities for treatment during pregnancy are summarized. Surgical treatment of the adnexal masses has to be performed with adequate staging and debulking equal to the treatment of non-pregnant women. However, whereas during organogenesis abortion has to be considered prior to chemotherapy, later in pregnancy surgical debulking as complete as possible, followed by taxol-platinum chemotherapy is indicated. If the fetus is not viable at the time of primary surgery, neoadjuvant chemotherapy and complementation of surgery after delivery of the baby should be performed. It should be stressed that chemotherapy for ovarian cancer applied during pregnancy appears to be safe. However, no studies have evaluated the long-term consequences for children exposed to intra-uterine chemotherapy. Aspiration of cysts should be avoided, as the correlation between the histological evaluation of an ovarian malignancy and the cytological evaluation of aspirates is poor. Moreover, spillage of malignant cysts is hazardous for the patient.

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“…Paclitaxel administered in early pregnancy in rats, may cause craniofacial malformations, diaphragmatic hernias, kidney and cardiovascular defects. 31 But carboplatin and paclitaxel did not affect postnatal differentiation like behavioural development, learning ability, motor activity, memory or emotional development. 32,33 Chemotherapy is contraindicated in first trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 93%

Successful treatment of clear cell carcinoma of ovary during pregnancy: a case report

Ashok

Kannan

2021

Int J Reprod Contracept Obstet Gynecol

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The incidence of malignant ovarian tumor is rare during pregnancy. Most women hope to maintain the pregnancy and preserve fertility thus increasing the need for standard guidelines regarding surgery and chemotherapy for safe oncologic and fetal outcomes. Here we present a 30-years-old primigravida, diagnosed with bilateral ovarian mass during routine ultrasound imaging at 8 weeks of gestation. CA125 was 14.2 U/ml. MRI pelvis taken at 13 weeks showed bilateral complex cystic masses with internal septations. The patient underwent bilateral salphingo-oopherectomy and infracolic omentectomy during 18th week of gestation, the histopathology showing clear cell carcinoma with capsular invasion and microscopic omental deposit thus staged as IIIA. She was planned for adjuvant chemotherapy comprising of paclitaxel and carboplatin during the 21st week along with serial ultrasounds for fetal monitoring. After 5 cycles, at 37 weeks of gestation, she was taken up for elective LSCS followed by completion of surgery for ovarian malignancy, that is, hysterectomy with bilateral pelvic lymphadectomy. Endometrium showed gestational changes with all lymph nodes being negative for tumor deposits. A healthy male child weighing 3.4 kg was delivered. She was given 6th cycle of chemotherapy post-surgery and two years later, mother and baby are doing well and on regular follow up. Thus, the successful treatment of clear cell ovarian carcinoma in this woman with safe pregnancy outcomes can be attributed to timely diagnosis and feasibility of surgery and chemotherapy during second trimester.

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REPRODUCTION STUDIES OF CARBOPLATIN(II) : Intravenous administration to rats during the period of fetal organogenesis

Cited by 8 publications

References 11 publications

Epithelial ovarian cancer in pregnancy: a review of the literature

Epithelial ovarian cancer in pregnancy: a review of the literature

Adnexal Masses in Pregnancy

Successful treatment of clear cell carcinoma of ovary during pregnancy: a case report

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