Reproductive adverse effects of fipronil in Wistar rats

Ohi, Masahiko; Dalsenter, Paulo Roberto; Andrade, Andrey José de; Nascimento, Aguinaldo José do

doi:10.1016/j.toxlet.2003.08.008

Cited by 93 publications

(60 citation statements)

References 16 publications

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“…Furthermore, Fipronil altered the normal function of the endocrine system and caused adverse reproductive effects in female "Winstar" rats (Ohi et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of genotoxicity in Rhamdia quelen (Pisces, Siluriformes) after sub-chronic contamination with Fipronil

Ghisi

Ramsdorf

Ferraro

et al. 2010

Environ Monit Assess

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Diverse genetic biomarkers have been used to evaluate the effects of pollution by mutagenic agents such as metals and pesticides, as well as a large variety of chemical substances derived from human activities. This work researched the effects that an exposure of 60 days to the insecticide Fipronil (concentrations of 0.05, 0.10 and 0.23 μg/L) can cause in the fish Rhamdia quelen using Comet assay with gills, histopathological analysis of gills and the Piscine Micronucleus test and Nuclear Morphological Alterations. The results for the Comet assay and for gills histopathological injuries showed no difference between the control group and the contaminated groups. In the Piscine Micronucleus test, the smallest concentration of Fipronil (0.05 μg/L) was similar as the control group, while concentrations of 0.10 and 0.23 μg/L caused more damage to the DNA. These results suggested that only the highest concentrations of Fipronil tested cause damage in erythrocytes, but none of these concentrations was sufficient to alter the DNA in the gill cells. R. quelen may be a less sensitive bioindicator than other fish that have been tested. On the other hand, the concentrations used may not have been sufficient to detect alterations in the DNA of R. quelen with the chosen tests. Works like this take on great importance given the enormous quantity of substances that are thrown daily into the environment in an uncontrolled way, without evaluation of the consequences. The application of these tests with other concentrations, tissues and exposure times is suggested for future works.

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“…Furthermore, Fipronil altered the normal function of the endocrine system and caused adverse reproductive effects in female "Winstar" rats (Ohi et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of genotoxicity in Rhamdia quelen (Pisces, Siluriformes) after sub-chronic contamination with Fipronil

Ghisi

Ramsdorf

Ferraro

et al. 2010

Environ Monit Assess

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show abstract

“…[10] Ohi et al [11] showed that administration of an insecticide fipronil causes a significant reduction in estradiol level in female Wistar rats. Similarly, Gojmerac et al [12] showed that lindane, atrazine and simazine cause a decrease in circulating estradiol levels in rats.…”

Section: Resultsmentioning

confidence: 99%

Bio-Remedial Effect of Curcuma Longa on Estrogen and Sub-Cellular Structures of Ovaries of Pesticide Exposed Mice

2017

WJPR

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Pesticides are some of the most frequently released toxic chemicals into the environment. Although the use of pesticides enhances crop productivity, human beings also pay a price for the benefits.Chlorpyrifos (an organophosphate) is a broad-spectrum insecticide against a variety of insects and mites in agriculture and allied sectors.After absorption through the guts and lungs, it rapidly distributes to all organs exerting damaging effects at cellular and sub-cellular levels.The present work is designed to study the bio-remedial effect of Curcuma longa (Turmeric) on estrogen and sub-cellular structure of ovary of Chlorpyrifos exposed Swiss albino mice. Chlorpyrifos administration at 6 mg/kg b.w./day for 8 weeks was followed by 8 weeks administration of alcoholic rhizome extract (5% Ethanol) of Curcuma longa at 50 mg/kg b.w./day. Estrogen level was increased in Chlorpyrifos administered group while it gradually decreased in Curcuma longa administered group. Degeneration of nucleus, nuclear membrane, mitochondria, endoplasmic reticulum and Golgi complex was observed in Chlorpyrifos administered group, while Curcuma longa restored mitochondria, nuclear membrane, nucleus, endoplasmic reticulum and Golgi complex effectively. Thus it is evident from the study that Curcuma longa plays an effective role against Chlorpyrifos induced toxicity on estrogen. It also maintains histology of ovary effectively. It restores cellular and sub-cellular toxicity of Chlorpyrifos exposed ovary effectively and restores normal function of ovary in female.

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“…Higher doses of Frontline also reduced the number of female rats who were able to become pregnant following mating (Ohi et al, 2004). Offspring of rats fed fipronil during pregnancy were smaller than offspring of unexposed rats.…”

Section: Effects Of Other Insecticides or Mixture Of Insecticides On mentioning

confidence: 93%

“…A single dose of Frontline approximately doubled the time between periods of estrus in female rats (Ohi et al, 2004). Higher doses of Frontline also reduced the number of female rats who were able to become pregnant following mating (Ohi et al, 2004).…”

Section: Effects Of Other Insecticides or Mixture Of Insecticides On mentioning

confidence: 94%

Reproductive and Developmental Toxicity of Insecticides

Ngoula¹,

Ngouateu²,

Raphaël³

et al. 2012

Insecticides - Advances in Integrated Pest Management

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Reproductive adverse effects of fipronil in Wistar rats

Cited by 93 publications

References 16 publications

Evaluation of genotoxicity in Rhamdia quelen (Pisces, Siluriformes) after sub-chronic contamination with Fipronil

Evaluation of genotoxicity in Rhamdia quelen (Pisces, Siluriformes) after sub-chronic contamination with Fipronil

Bio-Remedial Effect of Curcuma Longa on Estrogen and Sub-Cellular Structures of Ovaries of Pesticide Exposed Mice

Reproductive and Developmental Toxicity of Insecticides

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