Reproductive aging: insights from model organisms

Ye, Alice L.; Bhalla, Needhi

doi:10.1042/bst20110694

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Building upon these properties, several previous works described different aspects of oogenesis at some phases of germline aging in C. elegans (Hughes et al 2007;Andux & Ellis 2008;Luo et al 2009;Luo et al 2010;Ye & Bhalla 2011;Wang et al 2014;Bohnert & Kenyon 2017;Templeman & Murphy 2018). These works showed that aging oocytes undergo gross morphological and functional changes.…”

Section: Introductionmentioning

confidence: 97%

Oocyte Aging is Controlled by Mitogen Activated Protein Kinase Signaling

Achache

Falk

Lerner

et al. 2020

Preprint

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Oogenesis is one of the first processes to fail during aging. In women, most oocytes cannot successfully complete meiotic divisions during the fourth decade of life. Studies of the nematode Caenorhabditis elegans have uncovered conserved genetic pathways that control lifespan, but our knowledge regarding reproductive aging in worms and humans is limited. Specifically, little is known about germline internal signals that dictate the oogonial biological clock. Here, we report a thorough characterization of the changes in the worm germline during aging. We found that shortly after ovulation halts, germline proliferation declines, while apoptosis continues, leading to a gradual reduction in germ-cell numbers. In late aging stages, we observed that meiotic progression is disturbed and crossover designation and DNA double-strand break repair decrease. In addition, we detected a decline in the quality of mature oocytes during aging, as reflected by decreasing size and elongation of interhomolog distance, a phenotype also observed in human oocytes. Many of these altered processes were previously attributed to MAPK signaling variations in young worms. In support of this, we observed changes in activation dynamics of MPK-1 during aging. We therefore tested the hypothesis that MAPK controls oocyte quality in aged worms using both genetic and pharmacological tools. We found that in mutants with high levels of activated MPK-1, oocyte quality deteriorates more rapidly than in wild-type worms, whereas reduction of MPK-1 levels enhances quality. Thus, our data indicate that MAPK signaling controls germline aging and could be used to attenuate the rate of oogenesis quality decline

show abstract

Section: Introductionmentioning

confidence: 97%

Oocyte Aging is Controlled by Mitogen Activated Protein Kinase Signaling

Achache

Falk

Lerner

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Building upon these properties, several previous works described different aspects of oogenesis at certain phases of germline aging in C . elegans (Andux & Ellis, 2008; Bohnert & Kenyon, 2017; Hughes et al, 2007; Luo et al, 2009, 2010; Templeman & Murphy, 2018; Wang et al, 2014; Ye & Bhalla, 2011). These works showed that aging oocytes undergo gross morphological and functional changes.…”

Section: Introductionmentioning

confidence: 99%

Oocyte aging is controlled by mitogen‐activated protein kinase signaling

et al. 2021

View full text Add to dashboard Cite

Oogenesis is one of the first processes to fail during aging. In women, most oocytes cannot successfully complete meiotic divisions already during the fourth decade of life. Studies of the nematode Caenorhabditis elegans have uncovered conserved genetic pathways that control lifespan, but our knowledge regarding reproductive aging in worms and humans is limited. Specifically, little is known about germline internal signals that dictate the oogonial biological clock. Here, we report a thorough characterization of the changes in the worm germline during aging. We found that shortly after ovulation halts, germline proliferation declines, while apoptosis continues, leading to a gradual reduction in germ cell numbers. In late aging stages, we observed that meiotic progression is disturbed and crossover designation and DNA double‐strand break repair decrease. In addition, we detected a decline in the quality of mature oocytes during aging, as reflected by decreasing size and elongation of interhomolog distance, a phenotype also observed in human oocytes. Many of these altered processes were previously attributed to MAPK signaling variations in young worms. In support of this, we observed changes in activation dynamics of MPK‐1 during aging. We therefore tested the hypothesis that MAPK controls oocyte quality in aged worms using both genetic and pharmacological tools. We found that in mutants with high levels of activated MPK‐1, oocyte quality deteriorates more rapidly than in wild‐type worms, whereas reduction of MPK‐1 levels enhances quality. Thus, our data suggest that MAPK signaling controls germline aging and could be used to attenuate the rate of oogenesis quality decline.

show abstract

Reproductive aging: insights from model organisms

Cited by 2 publications

References 41 publications

Oocyte Aging is Controlled by Mitogen Activated Protein Kinase Signaling

Oocyte Aging is Controlled by Mitogen Activated Protein Kinase Signaling

Oocyte aging is controlled by mitogen‐activated protein kinase signaling

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