Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study

Saeed, Ayesha; Akhtar, Muhammad Furqan; Saleem, Ammara; Akhtar, Bushra; Sharif, Ali

doi:10.1007/s11356-023-26565-6

Cited by 23 publications

(2 citation statements)

References 60 publications

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“…These findings of the present study are only partially consistent with the results of earlier studies, although the duration of administration is different. Increases in insulin levels were detected in Wistar rats treated with MPs (2.5, 5, and 10 mg/kg/day) for 45 days, but mice treated with MPs (5 and 15 mg/kg) for 21 days did not show any significant alteration in insulin secretion [17,47]. Therefore, our results provide additional evidence that the MP-induced disruption of the lipid and Glu metabolism in the liver is associated with the disruption of insulin resistance.…”

Section: Discussionmentioning

confidence: 56%

Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice

Roh,

Kim,

Song

et al. 2024

IJMS

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The impact of microplastics (MPs) on the metabolic functions of the liver is currently unclear and not completely understood. To investigate the effects of the administration of MPs on the hepatic metabolism of normal and obese mice, alterations in the lipid, glucose (Glu), and amino acid regulation pathways were analyzed in the liver and adipose tissues of C57BL/6Korl (wild type, WT) or C57BL/6-Lepem1hwl/Korl mice (leptin knockout, Lep KO) orally administered polystyrene (PS) MPs for 9 weeks. Significant alterations in the lipid accumulation, adipogenesis, lipogenesis, and lipolysis pathways were detected in the liver tissue of MP-treated WT and Lep KO mice compared to the vehicle-treated group. These alterations in their liver tissues were accompanied by an upregulation of the serum lipid profile, as well as alterations in the adipogenesis, lipogenesis, and lipolysis pathways in the adipose tissues of MP-treated WT and Lep KO mice. Specifically, the level of leptin was increased in the adipose tissues of MP-treated WT mice without any change in their food intake. Also, MP-induced disruptions in the glycogenolysis, Glu transporter type 4 (GLUT4)-5′ AMP-activated protein kinase (AMPK) signaling pathway, levels of lipid intermediates, and the insulin resistance of the liver tissues of WT and Lep KO mice were observed. Furthermore, the levels of seven endogenous metabolites were remarkably changed in the serum of WT and Lep KO mice after MP administrations. Finally, the impact of the MP administration observed in both types of mice was further verified in differentiated 3T3-L1 adipocytes and HepG2 cells. Thus, these results suggest that the oral administration of MPs for 9 weeks may be associated with the disruption of lipid, Glu, and amino acid metabolism in the liver tissue of obese WT and Lep KO mice.

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Section: Discussionmentioning

confidence: 56%

Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice

Roh,

Kim,

Song

et al. 2024

IJMS

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“…Although few studies investigated the sex differences associated with MPs/NPs exposure, evidence suggests that liver metabolic and toxic effects may be worse for females [ 180 , 181 ], given the major impact of these plastic particles and their associated chemical additives (i.e., EDCs) on female reproductive parameters and functions [ 181 , 182 , 183 , 184 ].…”

Section: Nutrition Environmental Pollutants and Nafldmentioning

confidence: 99%

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Dolce

Torre

2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause–effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.

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Health risk of human exposure to microplastics: a review

Tang,

Li,

et al. 2024

Environ Chem Lett

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Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study

Cited by 23 publications

References 60 publications

Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice

Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution

Health risk of human exposure to microplastics: a review

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