Reproductive cycles of the domestic bitch

Concannon, Patrick W.

doi:10.1016/j.anireprosci.2010.08.028

Cited by 297 publications

(389 citation statements)

References 36 publications

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“…Although some studies in bitches report endometrial histological alterations at different moments of the cycle and pathological or hormone induced alterations, no studies were found relating the specific phases of the major hormonal alterations of E2 and P4 during diestrus, described by Fonseca et al (2012) and Concannon (2011), with the morphological and physiological characteristics of the endometrium and its cell proliferation. Knowledge about the morphological changes and proliferation of endometrial cells during the diestrus phase in bitches is important to better comprehend the physiology and endocrinology of canines.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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This study aimed to determine the histological features of the endometrium of bitches, as well as the cell proliferation at specific moments of diestrus, 10, 20, 30, 40, 50 and 60 days post ovulation, correlating the endometrial thickness with the uterine cell proliferation and the metabolic state (weight, blood glucose and plasma cholesterol) of the animals. Therefore, the right and left uterine horns of 26 clinically healthy bitches submitted to ovariohysterectomy were histologically analyzed 10, 20, 30, 40, 50 and 60 days post ovulation. The hematoxylin-eosin and AgNOR staining techniques were performed. All parameters were evaluated by ANOVA and post-hoc Tukey test (p<0.05). The correlation between endometrial thickness and uterine cell proliferation, weight, blood glucose and plasma cholesterol of animals was observed using the Pearson method (p<0.05). In the present study, it is concluded that endometrial thickness does not differ at any of the moments analyzed in diestrus. The endometrial thickness is not influenced by hormones, weight, blood glucose or serum cholesterol of bitches in this phase of the estrous cycle. However, there is greater cell proliferation in the endometrium at day 40 compared to day 60 post ovulation under the influence of the endocrine profile.

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Section: Introductionmentioning

confidence: 99%

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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“…Entre los animales domésticos, la perra (Canis lupus familiaris) posee una biología reproductiva excepcional, clasificándosela como hembra monoéstrica típica, polítoca, no estacional y ovuladora espontánea (Concannon, 2011), con un intervalo interestral (IIE) entre 4 y 12 meses (Sánchez, 1999).…”

Section: Fisiología Reproductiva De La Perraunclassified

“…A este periodo le sigue la fase del proestro, con una duración promedio de nueve días, que se caracteriza por una importante actividad folicular y secreción de 17β-estradiol, con la aparición de signos clínicos tales como edema vulvar, descarga vaginal sanguinolenta y atracción del macho. Endocrinológicamente, el proestro finaliza con la aparición del pico de hormona luteinizante (LH) (Concannon, 2011). En la fase siguiente, el estro, aparece la receptividad sexual y una marcada queratinización del epitelio vaginal, con una duración promedio de nueve días.…”

Section: Fisiología Reproductiva De La Perraunclassified

“…Durante el primer tercio del estro suele ocurrir el pico de LH y la ovulación con el consecuente desarrollo de los cuerpos hemorrágicos y cuerpos lúteos (Groppetti et al, 2015). Una vez finalizada la receptividad sexual y que el epitelio vaginal disminuye significativamente el nivel de queratinización celular, se señala que ha comenzado el metaestro o diestro (fase lútea), durante el cual, los niveles plasmáticos de progesterona (P 4 ) se mantienen elevados (>2 ng/ml) por alrededor de 60 a 90 días (Concannon, 2011).…”

Section: Fisiología Reproductiva De La Perraunclassified

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Fundamentos y Consideraciones de la Patología Endometrial Canina

Riquelme

Ruiz

2017

Rev. investig. vet. Perú

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RESUMENEl estudio de las patologías reproductivas es de importancia para el adecuado abordaje clínico y médico. El objetivo del presente artículo fue realizar una investigación bibliográfica sobre los fundamentos y consideraciones de la patología endometrial canina, con énfasis en la hiperplasia endometrial quística y la piometra, buscando sostener o refutar el concepto arraigado o dogma, acerca de la condicionalidad existente entre ellas, el cual ha sido denominado complejo hiperplasia endometrial quística-piometra. De acuerdo a la evidencia analizada, se puede señalar que en la perra existen dos tipos de lesiones uterinas comunes que pueden ser de presentación independiente: alteraciones del crecimiento (hiperplasia) y alteraciones inflamatorias/infecciosas (endometritis-piometra). En la etiopatogenia de ambas entidades, el rol de la progesterona, en tanto generadora de cambios celulares y moleculares en el epitelio uterino, resulta indiscutible.Palabras clave: canino, endometrio, piometra, hiperplasia endometrial quística ABSTRACTThe study of reproductive diseases is of great importance for clinical and medical approach. The aim of this article was to conduct a literature search on the grounds and considerations of canine endometrial pathology, with emphasis on endometrial cystic hyperplasia and pyometra, seeking support or refute the established concept or dogma, about the existing conditionality between them, which has been called cystic endometrial hyperplasia pyometra complex. According to the evidence, it is noted that there are two

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“…Canine reproductive physiology depicts several characteristics distinguishing this species from other domestic animals, particularly non-carnivorous. Of particular interest is the relatively long estrous phase and a remarkable long luteal phase which is of similar length in pregnant and non-pregnant cycles [38]. The dog presents an endotheliochorial placenta type, where the invasive trophoblast destroys the luminal epithelium and the underlying lamina propria in the process of implantation and placentation [39,40].…”

Section: Introductionmentioning

confidence: 99%

Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium

et al. 2016

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Putative changes in E-cadherin and β-catenin during implantation in dogs are of interest to study, as they are both relevant for epithelial integrity. E-cadherin and β-catenin were immunolocalised in the canine cyclic and early pregnant endometrium, using monoclonal antibodies. Both molecules were detected in all types of endometrial epithelia (surface, superficial glandular and deep glandular epithelia) at all stages of the estrous cycle and in early placental structures. E-cadherin depicted a gradient of immunoreaction, intensity apparently being lowest in the surface epithelium to progressively increase towards the deepness of the endometrial glands, regardless of the stage of estrous cycle. The overall immunostaining was, however, weaker at diestrus. In pregnant samples trophoblast immunolabeling was stronger than in the endometrial surface epithelium; in the latter, the cytoplasmic pattern predominated over the membranous, as was also seen in the giant decidual cells in the labyrinth. In the early placenta, only trophoblast cells and lacunae retained membrane signals. β-catenin membrane labeling appeared relatively constant through the cycle, although a tendency towards a decrease in intensity was detected at the secretory stages. In addition, a dislocation of the immunoreaction to the cytoplasm was observed in both the surface and the glandular epithelia in particular stages of the cycle. In early pregnancy, a loss of the membranous pattern was observed in the surface epithelium and labyrinth, but neither on trophoblast nor in lacunae. The results showed the existence of a softening of adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during implantation.

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Reproductive cycles of the domestic bitch

Cited by 297 publications

References 36 publications

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Fundamentos y Consideraciones de la Patología Endometrial Canina

Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium

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