Reproductive Effects of Occupational DDT Exposure among Male Malaria Control Workers

Salazar-García, F.; Gallardo-Díaz, Esperanza; Cerón-Mireles, Prudencia; Loomis, Dana; Borja-Aburto, Víctor Hugo

doi:10.1289/ehp.6759

Cited by 33 publications

(10 citation statements)

References 35 publications

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“…However, because of their chemical stability, lipophilic nature, and propensity to bioaccumulate, DDT/DDE remain ubiquitous contaminants in food, human adipose tissue, and human breast milk (4). Furthermore, DDT is still used today in many countries where malaria is a public health problem (5). For example, 23 countries in Africa, Asia, and Latin America currently use DDT to control disease-carrying insects (6).…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women

Perry

Ouyang

Korrick

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Basic health indicators, such as body mass index (BMI), have been associated with serum 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT/DDE) levels; however, both positive and inverse associations of BMI with serum DDT/DDE have been reported. Given the association of BMI with a number of outcomes, it may confound studies of DDT/DDE-associated health effects. We investigated the relationship of BMI with serum DDT/DDE accounting for other determinants of exposure among women with relatively recent environmental exposures to DDT. Methods: Serum DDT/DDE was analyzed in 466 nonsmoking, nulliparous women recruited from Anhui province in China between 1996 and 1998 as part of a reproductive health study of textile workers. The women in the sample were born between 1963 and 1977, 8 to 21 years before China's 1984

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Section: Introductionmentioning

confidence: 99%

Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women

Perry

Ouyang

Korrick

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The present cross-sectional results cannot provide causal evidence, but they suggest two hypotheses: (1) folate and cysteine may increase metabolism and excretion of DDT and its metabolites, and (2) DDT decreases the levels of folate and cysteine in the body. Although DDT has been banned in most countries, it is still used in some for malarial vector control [7][8][9][10], and its persistence in the environment leads to continued human exposure even after its use has stopped [5]. Furthermore, because DDT has a long half-life in humans, the body burden of its residues remains long after exposure [13].…”

Section: Discussionmentioning

confidence: 99%

“…Use of DDT in the United States was banned by the Environmental Protection Agency in 1972, except in cases of public health emergencies [6]. By the 1980s, its use was banned in most developed countries, although DDT is still used today in many countries in which malaria is a public health problem [7][8][9][10]. China banned agricultural use of DDT in 1984 but continues to use it for malaria control in some regions [11,12].…”

Section: Introductionmentioning

confidence: 99%

Serum folate and DDT isomers and metabolites are inversely associated in Chinese women: A Cross-Sectional Analysis

Arguelles

Liu

Venners

et al. 2009

International Journal of Cardiology

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“…Өзінің жасушалар кеңісітігінде орын алу қасиетімен адам ағзасына анағұрлым қауіп туғызатын, иммунды және репродуктивті жүйелер ауруларын, балаларда тума ақаулар, онкологиялық аурулармен жүретін көптеген патологиялық жағдай-лармен үдерістердің себептері болып табылады [2][3][4][5][6][7]. ТОЛ зияндылығы дамып жатқан ұрпаққа плацента арқылы, ал нәрестеге емшек сүті арқылы өтеді [8][9].…”

Section: кіріспеunclassified

Features of the endocrine system of female adolescents in cotton-growing regions

Bapayeva¹,

Kulbayeva²,

Zhumadilova³

2017

J CLIN MED KAZ

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Objective: to study the features of the endocrine system during the puberty in females living in regions, where organochlorine pesticides are widely used.Materials and Methods:172 females (adolescents aged 10-17) were examined. They were divided into 2 groups, depending on their place of residence. The first (main) group included 89 females who from birth lived in a territory where organochlorine pesticides were widely used to grow cotton. The second (control) group included 83 females that did not live in such areas. Gonadotropic hormones -follicle stimulating (FSH), luteinizing (LH), prolactin (PL) -and steroid hormones -estradiol (E2), cortisol (K), dehydroepiandrosterone (DHEA) -were examined in all girls.Results:It was found that the levels of FSH and LH in the females of the main group were significantly lower (p>0.02) during the whole period of puberty compared to their peers. Thus, the level of FSH at the age of 15-17 years was in the main group -10.79 ± 0.98 mU / l compared to 16.26 ± 0.21 mU / l, and the level of LH -10.95 ± 0.66 mU / L and 18.42 ± 1.28 mU / l, respectively. A similar pattern has been established with respect to prolactin at the age of 10-12 years and 13-14 years.Conclusion: the females of the main group have a decreased production of gonadotropic and steroid hormones in the period of the formation of the reproductive system,.Keywords: organochlorine pesticides, endocrine status, reproductivehealth. Зерттеудің мақсаты: хлорорганикалық пестицидтер кеңінен қолданылған аймақта тұратын жасөспірім қыздардың эндокринді жағдайының ерекшеліктерін зерттеу. Features of the endocrine system of female adolescents in cotton-growing regionsӘдістері: 10-17 жас аралығындағы 172 жасөспірім қыздарға (89 негізгі топтағы және 83 -салыстырмалы) зерттеу жүргізілді. Тұрғылықты жеріне байланысты олар 2 топқа бөлінді. Бірінші (негізгі) топқа, мақтаны өсіруде хлорорганикалық пестицидтерді кеңінен қолданған аумақта тұратын 89 қыздар кірді.Екінші топқа (салыстырмалы) ауыл шаруашылығында мал шаруашылығымен айналысатын аумақта тұратын 83 қыз кірді. Ол қыздарда гонадотропты (ФСГ, ЛГ, ПЛ) және стероидты гормондарға (Е2, кортизол, ДГЭАСанықтау жүргізілді.Нәтижесі: Жыныстық жетілу кезеңі бойынша негізгі топтағы қыздарда ФСГ және ЛГ деңгейлері құрыбыларымен салыстырғанда анық төмен болғандығы анықталды (р>0,02). Сонымен, негізгі топта 15-17 жас шамасында ФСГ және Лг деңгейлері -10,79±0,98 mU/l қарсы 16,26±0,21 mU/l, ал ЛГ деңгейі -10,95±0,66 mU/l және 18,42±1,28 mU/l сәйкес құрады. 10-12 жас және 13-14 жаста пролактинге қатыстыда осыған ұқсас заңдылық тұрақталды.Қорытынды: Негізгі топтағы қыздарда репродуктивті жүйенің қалыптасуы кезеңінде гонадотропты және стероидты гормондар өндірілуінің төмендеуі орын алып отыр.Маңызды сөздер:хлорорганикалық пестицидтер, гормоналды жағдай, репродуктивті денсаулық.

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Reproductive Effects of Occupational DDT Exposure among Male Malaria Control Workers

Cited by 33 publications

References 35 publications

Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women

Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women

Serum folate and DDT isomers and metabolites are inversely associated in Chinese women: A Cross-Sectional Analysis

Features of the endocrine system of female adolescents in cotton-growing regions

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