Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance

González-Bulnes, Antonio; Torres-Rovira, Laura; Óvilo, Cristina; Astiz, Susana; Gómez-Izquierdo, E.; González-Añover, P.; Pallarés, Pilar; Perez-Solana, Maria L.; Sánchez-Sánchez, Raúl

doi:10.1016/j.ygcen.2011.12.038

Cited by 24 publications

(17 citation statements)

References 56 publications

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“…In the current study, lower cholesterol concentration in maternal plasma correlated with deficiencies in foetal development, which it is consistently with previous studies on GD 42 [16]. In contrast, poor availability of glucose, the main energy source for developing foetuses [40], affected foetal development on GD 90 but not on GD 70 in our study, consistent with reports that hypoglycaemia in early development is non-critical and can be compensated [41].…”

Section: Discussionsupporting

confidence: 92%

“…Maternal malnutrition compromises foetal metabolism and development, causing growth retardation and triggering adaptive changes in the foetus to increase likelihood of survival [14]. Work from other groups has shown that the maternal lipid profile and placental efficiency are strongly related to cholesterol and triglyceride availability for human and other animal foetuses, which affects their viability and growth [15,16,17,18,19,20]. The developing foetus requires substantial amounts of lipids, mainly polyunsaturated fatty acids (PUFA), the availability of which is determined largely by maternal circulating levels and placental transfer [21].…”

Section: Introductionmentioning

confidence: 99%

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Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition

García-Contreras

Vázquez-Gómez

Astiz

et al. 2017

IJMS

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Sex-related differences in lipid availability and fatty acid composition during swine foetal development were investigated. Plasma cholesterol and triglyceride concentrations in the mother were strongly related to the adequacy or inadequacy of foetal development and concomitant activation of protective growth in some organs (brain, heart, liver and spleen). Cholesterol and triglyceride availability was similar in male and female offspring, but female foetuses showed evidence of higher placental transfer of essential fatty acids and synthesis of non-essential fatty acids in muscle and liver. These sex-related differences affected primarily the neutral lipid fraction (triglycerides), which may lead to sex-related postnatal differences in energy partitioning. These results illustrate the strong influence of the maternal lipid profile on foetal development and homeorhesis, and they confirm and extend previous reports that female offspring show better adaptive responses to maternal malnutrition than male offspring. These findings may help guide dietary interventions to ensure adequate fatty acid availability for postnatal development.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition

García-Contreras

Vázquez-Gómez

Astiz

et al. 2017

IJMS

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“…In pregnant swine genetically predisposed to obesity, the number of conceptuses was found to be diminished and appeared to be related to lower placental expression of VEGF (Gonzalez‐Bulnes et al. ). These observations provide experimental evidence supporting the involvement of placental VEGF in HFD‐induced maternal obesity and poor pregnancy outcome.…”

Section: Introductionmentioning

confidence: 99%

“…This decline in angiogenic factor may function as a protective mechanism to reduce placental vascular development and thus maternal nutrient delivery to the fetus (Ma et al 2010). In pregnant swine genetically predisposed to obesity, the number of conceptuses was found to be diminished and appeared to be related to lower placental expression of VEGF (Gonzalez-Bulnes et al 2012). These observations provide experimental evidence supporting the involvement of placental VEGF in HFD-induced maternal obesity and poor pregnancy outcome.…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal western-style diet on amniotic fluid volume and amnion VEGF profiles in a nonhuman primate model

et al. 2018

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During pregnancy, high fat diet (HFD) induces maternal obesity, insulin resistance, and placental inflammatory responses that compromise placental and fetal development. Whether maternal HFD would adversely affect amniotic fluid volume (AFV) has not been explored. Vascular endothelial growth factor (VEGF) is expressed in the amnion and has been proposed as a regulator of AFV. Our aim was to investigate the effects of HFD on AFV and the associated changes in VEGF and soluble VEGF receptor 1 (sFlt‐1) expression profiles in three amnion regions of a nonhuman primate model. Further, we examined the relationships between VEGF expression and HFD‐induced changes in maternal metabolic status. Japanese macaques were maintained on control or HFD and amniotic fluid index (AFI) was measured as an ultrasonic estimate of AFV. Amniotic fluid VEGF concentrations were determined by ELISA and amnion VEGF and sFlt‐1 mRNA levels by real‐time RT‐qPCR. HFD increased maternal plasma triglyceride while glucose levels were unchanged. Maternal weight gain was found in diet‐sensitive animals whereas amniotic fluid VEGF concentration was reduced in diet‐resistant animals. HFD did not alter AFI and there was no correlation between AFI and maternal weight or amniotic fluid VEGF concentrations. VEGF mRNA levels were lowest in secondary placental amnion while sFlt‐1 mRNA were lowest in the primary placental amnion. HFD did not affect amnion VEGF or sFlt‐1 mRNA expression. These findings suggest that although maternal HFD increased maternal weight in diet‐sensitive and reduced amniotic fluid VEGF concentrations in diet‐resistant phenotype, AFV as indicated by the AFI, was not significantly affected.

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“…The reproductive physiology of sows is affected by various factors including the environment [3,7], hormones [10,15,16], diet [4,9], and genetics [5,13]. These factors are important not only for increasing litter sizes on commercial farms but also improving embryo production by somatic cell nuclear transfer (SCNT) in the laboratory.…”

mentioning

confidence: 99%

Relationship between pregnancy rate and serum progesterone concentration in cases of porcine embryo transfer

et al. 2014

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The level of P4 at the time of embryo transfer (ET) is important. P4 concentrations and numbers of corpora lutea for 126 recipients were evaluated. Nuclear transfer embryos were transferred into 126 surrogates. 11 maintained their pregnancy until full-term delivery, 17 miscarried, and implantation failed in 98 animals. P4 levels in the full-term group were significantly different from those of the pigs that aborted or in which implantation failed (p < 0.05). However, the numbers of corpora lutea were not significantly different. These findings indicate that the concentration of progesterone can be an important factor for successful ET in pigs.

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Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance

Cited by 24 publications

References 56 publications

Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition

Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition

Effects of maternal western-style diet on amniotic fluid volume and amnion VEGF profiles in a nonhuman primate model

Relationship between pregnancy rate and serum progesterone concentration in cases of porcine embryo transfer

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