Reproductive factors and its association with peripheral arterial disease in women aged 52–81 years: The KORA F4 study

Stöckl, Doris; Döring, Angela; Thorand, Barbara; Heier, Margit; Peters, Annette; Lamina, Claudia; Kronenberg, Florian; Meisinger, Christa

doi:10.1016/j.atherosclerosis.2013.01.035

Cited by 13 publications

(10 citation statements)

References 27 publications

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“…In a retrospective population-based study in Germany, menarche ≥15 years was associated with a 52% reduced odds of peripheral arterial disease compared with menarche at age 12 to 15 years. 117 The same study also found an association between later age at menarche and lower BMI, waist circumference, fasting glucose, and 2-hour glucose, trends that extended into the late menarche group (≥15 years). 118 More recent studies have suggested that later pubertal timing in fact has a negative effect.…”

Section: Metabolic and Cardiovascular Outcomesmentioning

confidence: 76%

Adult Consequences of Self-Limited Delayed Puberty

2017

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Delayed puberty is a common condition defined as the lack of sexual maturation by an age ≥2 SD above the population mean. In the absence of an identified underlying cause, the condition is usually self-limited. Although self-limited delayed puberty is largely believed to be a benign developmental variant with no long-term consequences, several studies have suggested that delayed puberty may in fact have both harmful and protective effects on various adult health outcomes. In particular, height and bone mineral density have been shown to be compromised in some studies of adults with a history of delayed puberty. Delayed puberty may also negatively affect adult psychosocial functioning and educational achievement, and individuals with a history of delayed puberty carry a higher risk for metabolic and cardiovascular disorders. In contrast, a history of delayed puberty appears to be protective for breast and endometrial cancer in women and for testicular cancer in men. Most studies on adult outcomes of self-limited delayed puberty have been in small series with significant variability in outcome measures and study criteria. In this article, we review potential medical and psychosocial issues for adults with a history of self-limited delayed puberty, discuss potential mechanisms underlying these issues, and identify gaps in knowledge and directions for future research.

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Section: Metabolic and Cardiovascular Outcomesmentioning

confidence: 76%

Adult Consequences of Self-Limited Delayed Puberty

2017

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“…KORA F4 was conducted between 2006 and 2008 and a total of 3080 individuals were finally included. 15,16 Lp(a) concentrations and LMW apo(a) phenotypes were measured in 3156 participants in KORA F3 and 3061 participants in KORA F4. In the KORA studies, PAD was defined as symptomatic disease according to the Edinburgh questionnaire or asymptomatic disease (ABI<0.90) or both.…”

Section: Methodsmentioning

confidence: 99%

Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

Laschkolnig¹,

Kollerits²,

Lamina³

et al. 2014

Cardiovascular Research

112

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AimsThe relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three independent cohorts and performed a Mendelian Randomization approach using instrumental variable regression.Methods and resultsLp(a) concentrations, apo(a) phenotypes, and one SNP in the LPA gene (rs10455872) were measured in the CAVASIC study, including 241 male patients with intermittent claudication and 246 age- and diabetes-matched controls as well as in the two population-based studies KORA F3 (n = 3184) and KORA F4 (n = 3080). In KORA F3/F4, 109/80 persons suffered from intermittent claudication, 200/144 from PAD, and 128/103 showed an ankle–brachial index (ABI) <0.9. In CAVASIC, adjusted logistic regression analyses revealed significant associations between an increase of log-Lp(a) per one standard deviation (SD) (OR = 1.28, P = 0.02) as well as LMW apo(a) phenotypes and symptomatic PAD (OR = 1.65, P = 0.03). Linear regression models with continuous ABI showed a significant association in the combined analyses of KORA F3/F4: an increase in log-Lp(a) per one SD (β = −0.006, P = 0.005) and the presence of LMW apo(a) phenotypes (β = −0.011, P = 0.02) or the minor allele of rs10455872 (ß = −0.016, P = 0.03) were associated with a decrease in ABI in the fully adjusted linear and instrumental variable regression models.ConclusionAnalyses in three independent populations showed significant associations of Lp(a) concentrations, LMW apo(a) phenotypes, and rs10455872 with PAD. This points to a causal relationship between Lp(a) and PAD since the genetically determined apo(a) phenotypes and SNP alleles are indeed associated with PAD.

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“…Reproductive parameters were obtained through personal interviews by trained medical staff in the KORA S4 and F4 surveys and have been described previously [25]. Most variables were obtained in both interviews and underwent rigorous quality assessment for internal validity.…”

Section: Methodsmentioning

confidence: 99%

Reproductive factors, intima media thickness and carotid plaques in a cross-sectional study of postmenopausal women enrolled in the population-based KORA F4 study

et al. 2014

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BackgroundReproductive events may affect the onset of chronic diseases. We examined the possible association between reproductive parameters and intima media thickness (IMT) or carotid plaques in the common carotid artery in a population-based sample.MethodsThis cross-sectional study analysed data of 800 postmenopausal women aged 50 to 81 years of the population-based KORA F4 study, conducted between 2006 and 2008 in Southern Germany. Reproductive parameters were obtained by standardised interviews.ResultsAge at menarche below 12 years compared to 12-15 years was significantly associated with carotid plaques (age-adjusted OR 2.23, 95% CI 1.13-4.43, p-value 0.018, multivariable adjusted 2.11, 1.05-4.26, 0.037), but not with IMT. Ever use of hormone replacement therapy was inversely associated with carotid plaques (age-adjusted 0.60, 0.44-0.81, p = 0.001, multivariable-adjusted 0.62, 0.45-0.86, 0.003) and IMT in the age-adjusted model (mean 0.89, 95% CI 0.88-0.90, p = 0.033) but not in the multivariable-adjusted model (mean 0.89, 95% CI 0.88-0.90, p = 0.075). Parity, age at menopause, time since menopause, duration of fertile period, current use of hormone replacement therapy, ever use of oral contraceptives, hysterectomy, bilateral oophorectomy, hot flashes and depressive mood in relation to the menopausal transition were not associated with carotid plaques or IMT.ConclusionOur study showed, that there may be an independent association between the reproductive parameters age at menarche and ever use of hormone replacement therapy with carotid plaques in the common carotid artery, but not with IMT. Further research, especially in studies with prospective population-based study design, is necessary to assess in detail what events in women’s life lead to increased IMT or CP.

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Reproductive factors and its association with peripheral arterial disease in women aged 52–81 years: The KORA F4 study

Cited by 13 publications

References 27 publications

Adult Consequences of Self-Limited Delayed Puberty

Adult Consequences of Self-Limited Delayed Puberty

Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

Reproductive factors, intima media thickness and carotid plaques in a cross-sectional study of postmenopausal women enrolled in the population-based KORA F4 study

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