Reproductive fitness in familial schizophrenia

Bassett, Anne S.; Bury, Alison; Hodgkinson, Kathy; Honer, William G.

doi:10.1016/0920-9964(96)00018-7

Cited by 76 publications

(31 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors have argued that since lower fertility has been consistent throughout the 20th century and has been reported in younger and older subjects, lower reproductive fitness in patients with schizophrenia may be an inherent part of the illness (25). Our finding of normal rates of general fertility in younger subjects with psychosis (and in younger women with nonaffective psychoses only) does not support this theory, although this may be due to the small numbers of subjects in these age groups.…”

Section: Discussionmentioning

confidence: 38%

The General Fertility Rate in Women With Psychotic Disorders

Howard¹,

Kumar²,

Leese³

et al. 2002

AJP

110

View full text Add to dashboard Cite

This study found markedly lower fertility rates in women with psychotic disorders than in matched normal comparison subjects, particularly in women with non-affective disorders. Knowledge of fertility rates in women with psychotic disorders is fundamental for clinicians and researchers, since it has implications for family planning services, prevention of obstetric complications, child-care support, and hypotheses about the etiology of these disorders.

show abstract

Section: Discussionmentioning

confidence: 38%

The General Fertility Rate in Women With Psychotic Disorders

Howard¹,

Kumar²,

Leese³

et al. 2002

AJP

110

View full text Add to dashboard Cite

show abstract

“…Reproductive fitness was estimated by the average number of liveborn offspring per subject in a specified group 14 18. The proportion of individuals childless was considered as an additional proxy for fitness 18.…”

Section: Methodsmentioning

confidence: 99%

“…The proportion of individuals childless was considered as an additional proxy for fitness 18. Data on the number of children born to study participants were collected via direct interviews and/or through collateral information from family history supplemented by genealogical records.…”

Section: Methodsmentioning

confidence: 99%

“…Data on the number of children born to study participants were collected via direct interviews and/or through collateral information from family history supplemented by genealogical records. Other pregnancy outcomes (eg, miscarriages, stillbirths) were not considered 18. We also recorded whether subjects were ever in a serious romantic relationship, which included marriage or a common-law arrangement of one year or more.…”

Section: Methodsmentioning

confidence: 99%

“…Based on the severity of the overall phenotype, we hypothesised that the mean number of liveborn offspring per subject with 22q11.2DS would be lower and that the proportion childless would be greater than for their siblings without 22q11.2 deletions. Furthermore, we predicted that decreased fitness within 22q11.2DS would be primarily associated with younger age and three phenotypes with independent evidence of fitness effects: CHD,15 16 mental retardation,17 and schizophrenia 18 19. We assessed sex as an independent factor but made no prediction, given that the neuropsychiatric conditions considered are known to have a disproportionate effect on the ability of men to find partners and to reproduce 18 19…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sex differences in reproductive fitness contribute to preferential maternal transmission of 22q11.2 deletions

Costain

Chow

Silversides

et al. 2011

Journal of Medical Genetics

View full text Add to dashboard Cite

show abstract

Fecundity of Patients With Schizophrenia, Autism, Bipolar Disorder, Depression, Anorexia Nervosa, or Substance Abuse vs Their Unaffected Siblings

Power¹,

Kyaga²,

Uher³

et al. 2013

JAMA Psychiatry

302

241

View full text Add to dashboard Cite

It is unknown how genetic variants conferring liability to psychiatric disorders survive in the population despite strong negative selection. However, this is key to understanding their etiology and designing studies to identify risk variants. Objectives: To examine the reproductive fitness of patients with schizophrenia and other psychiatric disorders vs their unaffected siblings and to evaluate the level of selection on causal genetic variants. Design: We measured the fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse and their unaffected siblings compared with the general population. Setting: Population databases in Sweden, including the Multi-Generation Register and the Swedish Hospital Discharge Register. Participants: In total, 2.3 million individuals among the 1950 to 1970 birth cohort in Sweden. Main Outcome Measures: Fertility ratio (FR), reflecting the mean number of children compared with that of the general population, accounting for age, sex, family size, and affected status. Results: Except for women with depression, affected patients had significantly fewer children (FR range for those with psychiatric disorder, 0.23-0.93; PϽ10 Ϫ10). This reduction was consistently greater among men than women, suggesting that male fitness was particularly sensitive. Although sisters of patients with schizophrenia and bipolar disorder had increased fecundity (FR range, 1.02-1.03; PϽ.01), this was too small on its own to counterbalance the reduced fitness of affected patients. Brothers of patients with schizophrenia and autism showed reduced fecundity (FR range, 0.94-0.97; PϽ.001). Siblings of patients with depression and substance abuse had significantly increased fecundity (FR range, 1.01-1.05; PϽ10 Ϫ10). In the case of depression, this more than compensated for the lower fecundity of affected individuals. Conclusions: Our results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism. Bipolar disorder did not seem to be under strong negative selection. Vulnerability to depression, and perhaps substance abuse, may be preserved by balancing selection, suggesting the involvement of common genetic variants in ways that depend on other genes and on environment.

show abstract

Reproductive fitness in familial schizophrenia

Cited by 76 publications

References 35 publications

The General Fertility Rate in Women With Psychotic Disorders

The General Fertility Rate in Women With Psychotic Disorders

Sex differences in reproductive fitness contribute to preferential maternal transmission of 22q11.2 deletions

Fecundity of Patients With Schizophrenia, Autism, Bipolar Disorder, Depression, Anorexia Nervosa, or Substance Abuse vs Their Unaffected Siblings

Contact Info

Product

Resources

About