Reproductive function in patients with malignant ovarian germ cell tumours

Чекини, Д. А.; Трякин, А. А.; Федянин, М. Ю.; Жорданиа, К. И.; Pokataev, Ilya; Bulanov, A.; Zakharova, T.; Тюляндин, С. А.

doi:10.18027/2224-5057-2017-2-47-53

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Беременность в сроки 1-3 года после завершения ХТ наступила у 33,3% женщин, 4-6 лет -у 38,9%, 7-10 лет -в 22,2%. Тем не менее следует учитывать мужской фактор и социальные причины, которые могли объяснить наступление беременности в сроки 1-3 года после завершения ХТ лишь у 1/3 пациенток [5].…”

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Reproductive function in persons who have been cured of cancer

Gavrilenko¹,

Валиев²,

Поликарпова³

et al. 2021

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Modern cancer therapy programs allow an increasing number of patients to be cured, and therefore the quality of their subsequent life is an important task of clinical oncology. The ability to realize reproductive potential is one of the main criteria for the quality of life. Nevertheless, chemoradiation therapy used in the treatment of malignant tumors can cause temporary or permanent infertility. Currently, there are options to protect the reproductive system from chemoradiation treatment (administration of ethinylestradiol drugs, gonadotropin-releasing hormone agonists) or harvesting seminal fluid/oocytes, and cryopreservation of ovarian tissue. However, the low awareness of doctors about modern reproductive technologies in the treatment of persons cured from cancer leads to the fact that these methods are not used actively enough. The article presents the main chemotherapy drugs used in the treatment of malignant tumors that can cause an impairment of reproductive function; describes their pathological effects on oocytes and spermatozoa; provides methods of protecting the reproductive function in persons who take chemoradiation therapy or have completed antitumor therapy.

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Reproductive function in persons who have been cured of cancer

Gavrilenko¹,

Валиев²,

Поликарпова³

et al. 2021

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Sonographic features of ovarian tumors in pregnant women before surgical intervention and chemotherapy

Gerasimova

Klimenko

2021

BRSMU

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The problem of ovarian tumor differential diagnosis is solved using comprehensive ultrasound examination at different levels of efficiency. However, ultrasound imaging is an operator-dependent technique due to subjective interpretation of results. The study was aimed to assess the ultrasound signs of benign and malignant ovarian germ cell tumors (OGCTs) in pregnant women in order to determine the feasibility of surgical treatment and chemotherapy. The study was carried out using the logistic regression models. A group of 199 pregnant women with benign and malignant OGCTs were enrolled. Of them, 183 patients had benign, and nine patients had malignant tumors. In order to assess menstrual function and fertility, seven pregnant women were enrolled, who had previously received treatment for malignant OGCTs. Pre-operative assessment results were compared with morphological assessment data. Organ-preserving surgical treatment was performed (unilateral adnexectomy); if necessary, the patients received cisplatin-based chemotherapy. Perinatal outcomes were assessed. The median observation time between the malignant OGCT detection and the end of the study was 66 months (12–240 months). It was found that comprehensive ultrasound examination and logistic regression models (sensitivity 100%, specificity 92.3%, overall accuracy 92.8%) enabled differential diagnosis of benign and malignant OGCTs. The number of unnecessary surgical procedures in patients with benign OGCTs was been limited, the pregnancy and childbirth outcomes were improved. Nine pregnant women received organ-preserving surgical treatment for malignant OGCTs, and three patients received chemotherapy after surgery, which allowed the patients to realize their reproductive potential.

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The importance of compression sonoelastography in multiparametric ultrasound examination in the detection of malignant formations of ovaries

Stasiv

2022

RDRT

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In Ukraine ovarian cancer ranks third among pelvic malignancies in women of childbearing age and ranks first in the structure of mortality of women from oncogynecological pathology. The aim of the study – to increase the diagnostic value of multiparametric ultrasound examination of ovarian malignancies using compression sonoelastography. Material and methods. A comprehensive radiological study of 48 patients with ovarian cancer was performed. The average age of patients was (45.22 ± 4.08) years. Ultrasound was performed on a HITACHI ALOCA ARIETTA 70 using a cavitary multifrequency sensor with a frequency of 7.5-10 mHz Compression elastography was used to assess the rigidity of the detected formation. Results. In 30 (62.5%) women in the sonoelastography mode different elastotype was detected, because the liquid component had a blue-green-red color corresponding to 0 elastotype, and the solid component and papillary growths were mapped mostly blue, rarely with green admixtures, ie. had IV-V elastotype on the UENO scale. The hardness index of the solid component ranged from 4.3 to 46 um.od. In 18 (37.5%) patients malignant were mapped in blue, which corresponded to the V elanotype according to UENO and had a high hardness index, which ranged from 5.2 to 56 um.od. All of these formations were classified as high-risk - O-RADS 5, as all formations were characterized by ultrasonic descriptors with a high degree of prediction of malignancy. Conclusions. Innovative technology of sonoelastography provides qualitatively new information about the elasticity of tissues and allows to assess the stiffness of ovarian tumors with high accuracy and specificity.

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Reproductive function in patients with malignant ovarian germ cell tumours

Cited by 3 publications

References 14 publications

Reproductive function in persons who have been cured of cancer

Reproductive function in persons who have been cured of cancer

Sonographic features of ovarian tumors in pregnant women before surgical intervention and chemotherapy

The importance of compression sonoelastography in multiparametric ultrasound examination in the detection of malignant formations of ovaries

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