Objective: In India, national databases indicate anaemia prevalence of 80 % among 6-35-month-old children and 58 % among 36-59-month-old children. The present study aimed to characterise anaemia and the associated factors among infants and pre-schoolers living in rural India. Design: Multivariate logistic regression analysis of data collected prior to an intervention trial. Fe-deficiency with anaemia (IDA), Fe deficiency with no anaemia (IDNA) and anaemia without Fe deficiency were defined. Serum ferritin, soluble transferrin receptor (sTfR) and sTfR/log ferritin index were used to indicate Fe status. Setting: Twenty-six villages of Nalgonda district, Telangana, India. Data were collected in community sites. Participants: Four hundred and seventy-six infants (aged 6-12 months), 316 pre-schoolers (aged 29-56 months) and their mothers. Results: Prevalence of anaemia among infants and pre-schoolers was 66·4 and 47·8 %, prevalence of IDA was 52·2 and 42·1 %, prevalence of IDNA was 22·2 and 29·8 %, prevalence of anaemia without Fe deficiency was 14·2 and 5·7 %. Among infants, anaemia was positively associated with maternal anaemia (OR = 3·31; 95 % CI 2·10, 5·23; P < 0·001), and sTfR/log ferritin index (OR = 2·21; 95 % CI 1·39, 3·54; P = 0·001). Among pre-schoolers, anaemia was positively associated with maternal anaemia (OR = 3·77; 95 % CI 1·94, 7·30; P < 0·001), sTfR/log ferritin index (OR = 5·29; 95 % CI 2·67, 10·50; P < 0·001), high C-reactive protein (OR = 4·39; 95 % CI 1·91, 10·06, P < 0·001) and young age (29-35 months: OR = 1·92; 05 % CI 1·18, 3·13, P = 0·009). Conclusions: Anaemia prevalence continues to be high among infants and pre-schoolers in rural India. Based on sTfR/ferritin index, Fe deficiency is a major factor associated with anaemia. Anaemia is also associated with inflammation among pre-schoolers and with maternal anaemia among infants and preschoolers, illustrating the importance of understanding the aetiology of anaemia in designing effective control strategies.
KeywordsAnaemia Infants Pre-schoolers India Risk factors sTfR/log ferritin index Global estimates indicate that 43 % of children under the age of 5 years suffer from anaemia (1) and that about half of anaemia is caused by Fe deficiency. However, the prevalence and aetiology of anaemia are likely to be context-specific (2) . Due to the high nutrient (e.g. dietary Fe) demands needed to support early physical growth, rapid brain development and early learning capacity, the infancy and pre-school periods are especially vulnerable to anaemia (3,4) . Anaemia and Fe deficiency are associated with perinatal mortality (5) , delayed child mental and physical development, negative behavioural consequences and reduced auditory and visual function (6,7) . Some of the consequences of early anaemia and Fe deficiency may be irreversible (8,9) . In low-and middle-income countries, epidemiological evaluation is important in designing anaemia control programmes (10,11) . In India, national databases indicate an alarming anaemia prevalence of 80 % a...