Reproductive Health in Scleroderma, Vasculitis, and Sjögren Syndrome

Abstract

Women with systemic chronic inflammatory disease, such as those with scleroderma, systemic vasculitis, and Sjögren syndrome, need preconception evaluation by a multidisciplinary team. Counseling and pregnancy management should be tailored to patients' needs, considering specific disease features, organ involvement, treatment options, and risk factors to minimize risks of maternal-fetal complications during pregnancy. Additionally, considerations regarding fertility, assisted reproductive techniques, and contraception also need to be addressed for these women. In this narrative review, we integrate the current published literature with our expert opinion to address the issues faced by patients with the aforementioned inflammatory conditions.