Reproductive health in women with serious mental illnesses

Özcan, Neslihan Keser; Boyacıoğlu, Nur Elçin; Enginkaya, Semra; Dinç, Hüsniye; Bilgin, Hülya

doi:10.1111/jocn.12332

Cited by 39 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The relationship between reproductive behavior and susceptibility to psychiatric disorders is likely complex and bidirectional. Individuals with psychiatric illness and their relatives may be more prone to risk taking and impulsive behavior, which cause early pregnancy and childbirth in women, or they may exhibit poor social interactions that result in delays in key reproductive transitions such as marriage, pregnancy and childbirth [15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

The genetic relationship between female reproductive traits and six psychiatric disorders

Amare

Zhou

et al. 2018

Preprint

View full text Add to dashboard Cite

Female reproductive behaviors have an important implication in evolutionary fitness and health of offspring. Previous studies have shown that age at first birth of women (AFB) is genetically associated with schizophrenia (SCZ). However, for most other psychiatric disorders and reproductive traits, the latent shared genetic architecture is largely unknown. Here we used the second wave of UK Biobank data (N=220,685) to evaluate the association between five female reproductive traits and polygenetic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N=429,178). We found that the PRS of attentiondeficit/hyperactivity disorder (ADHD) were strongly associated with AFB (genetic correlation of -0.68 ± 0.03 with p-value = 1.86E-89), age at first sexual intercourse (AFS) (-0.56 ± 0.03 with p-value = 3.42E-60), number of live births (NLB) (0.36 ± 0.04 with p-value = 4.01E-17) and age at menopause (-0.27 ± 0.04 with p-value = 5.71E-13). There were also robustly significant associations between the PRS of eating disorder (ED) and AFB (genetic correlation of 0.35 ± 0.06), ED and AFS (0.19 ± 0.06), Major depressive disorder (MDD) and AFB (-0.27 ± 0.07), MDD and AFS (-0.27 ± 0.03) and SCZ and AFS (-0.10 ± 0.03). Our findings reveal the shared genetic architecture between the five reproductive traits in women and six psychiatric disorders, which have a potential implication that helps to improve reproductive health in women, hence better child outcomes. Our findings may also explain, at least in part, an evolutionary hypothesis that causal mutations underlying psychiatric disorders have positive effects on reproductive success.

show abstract

Section: Introductionmentioning

confidence: 99%

The genetic relationship between female reproductive traits and six psychiatric disorders

Amare

Zhou

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Women with mental illness, however, often experience problems and increased risk of complications related to childbearing [10]. Female patients with psychiatric disorders seem to have more negative attributes with regard to sexuality and reproduction [11]. The complex picture of problems that women with BD face include: sexually risky behaviour during episodes of mania, health related risks for the mother and/or the baby, decisions regarding medication during pregnancy, as well as decisions related to unplanned/undesired pregnancy, and sexually transmitted infections [12–16].…”

Section: Introductionmentioning

confidence: 99%

Bipolar disorder in pregnancy and childbirth: a systematic review of outcomes

Rusner

Berg

Begley

2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundBipolar Disorder (BD) is a mental disorder usually diagnosed between 18 and 30 years of age; this coincides with the period when many women experience pregnancy and childbirth. As specific problems have been reported in pregnancy and childbirth when the mother has BD, a systematic review was carried out to summarise the outcomes of pregnancy and childbirth, in mother and child, when the mother has BD diagnosed before pregnancy.MethodsAn a priori protocol was designed and a systematic search conducted in PubMed, CINAHL, Scopus, PsycINFO and Cochrane databases in March 2015. Studies of all designs were included if they involved women with a diagnosis of bipolar disorder prior to pregnancy, who were pregnant and/or followed up to one year postpartum. All stages of inclusion, quality assessment and data extraction were done by two people. All maternal or infant outcomes were examined, and narrative synthesis was used for most outcomes. Meta-analysis was used to achieve a combined prevalence for some outcomes and, where possible, case and control groups were combined and compared.ResultsThe search identified 2809 papers. After screening and quality assessement (using the EPHPP and AMSTAR tools), nine papers were included. Adverse pregnancy outcomes such as gestational hypertension and antepartum haemorrhage occur more frequently in women with BD. They also have increased rates of induction of labour and caesarean section, and have an increased risk of mood disorders in the postnatal period. Women with BD are more likely to have babies that are severely small for gestational age (<2nd-3rd percentile), and it appears that those women not being treated with mood stabilisers in pregnancy might not have an increased risk of having a baby with congenital abnormalities.DiscussionDue to heterogeneity of data, particularly the use of differing definitions of bipolar disorder, narrative synthesis was used for most outcomes, rather than a meta-analysis.ConclusionsIt is evident that adverse outcomes are more common in women with BD and their babies. Large cohort studies examining fetal abnormality outcomes for women with BD who are not on mood stabilisers in pregnancy are required, as are studies on maternal-infant interaction.Electronic supplementary materialThe online version of this article (doi:10.1186/s12884-016-1127-1) contains supplementary material, which is available to authorized users.

show abstract

“…) and reproductive and mental health (Ozcan et al . ). It is through this that they can be equipped to recognise and respond to IPV appropriately.…”

Section: Discussionmentioning

confidence: 97%

Development of a practice framework for improving nurses’ responses to intimate partner violence

Bradbury‐Jones

Clark

Parry

et al. 2016

Journal of Clinical Nursing

View full text Add to dashboard Cite

Access to adequate and timely intimate partner violence education and training is important in improving nurses' responses to intimate partner violence. Getting this right can lead to enhanced safety planning and better health outcomes for women who experience intimate partner violence. Although difficult to measure as an outcome, nurses' improved responses can contribute to higher rates of referral for help and reduction in intimate partner violence rates.

show abstract

Reproductive health in women with serious mental illnesses

Abstract: The results of this study may be useful for nurses in the clinical field for calling an attention and raising an awareness of the reproductive health problems of women with psychiatric disorders, taking the necessary preventive measures, and developing damage-reducing strategies.

Cited by 39 publications

References 32 publications

The genetic relationship between female reproductive traits and six psychiatric disorders

The genetic relationship between female reproductive traits and six psychiatric disorders

Bipolar disorder in pregnancy and childbirth: a systematic review of outcomes

Development of a practice framework for improving nurses’ responses to intimate partner violence

Contact Info

Product

Resources

About