Background: In recent years, the importance of health literacy in public health has attracted global interest as it affects people’s ability to make health decisions and is associated with health outcomes. Reproductive health literacy (RHL), in particular, affects adolescent’s ability to make sound sexual and reproductive health (SRH) decisions and is shown as a strong predictor of adolescent’s RH outcomes. This study aimed to determine the RHL status and associated factors among high school adolescents in Eastern Ethiopia.Methods: Institutional‐based cross‐sectional study was conducted among 403 randomly selected secondary school adolescents in Boke District, Eastern Ethiopia, from January 1–5, 2021. Data were collected through pretested, structured, and self‐administered questionnaires, entered into Epidata version 3.1, and analyzed by Statistical Package for the Social Sciences (SPSS) version 23. A comprehensive questionnaires were designed to measure adolescents’ RHL in four functional dimensions (access, understand, appraise, and apply information). A participant’s RHL was categorized as limited or adequate, based on a transformed scale of measurements from 0 to 50. The predictors of the outcome variable were assessed using a logistic regression model and reported using adjusted odds ratio (AOR) with 95% confidence interval (CI). A statistical significance was declared at a p value of <0.05.Results: The overall prevalence of limited RHL among adolescents was 81.6% with a 95% CI (77.5%−85.2%). In‐school male adolescents were 52% less likely to score in limited RHL status than their female counterparts (AOR = 0.48, 95% CI = 0.26, 0.88). Adolescents who reported attending reproductive health (RH)–related topics in class were 56% less likely to score in limited RHL status than their counterparts (AOR = 0.44, 95% CI = 0.23, 0.84). Furthermore, adolescents who reported using at least one RH service component were 60% times less likely to score in limited RHL status compared to their counterparts (AOR = 0.40, 95% CI = 0.23, 0.70).Conclusion: A high proportion of school adolescents have limited RHL, suggesting school adolescents are at higher risk of RHL–related problems. Improving adolescent RHL with due attention to school, SRH education is warranted.