Reproductive History in Mothers of Children with Neural Tube Defects

Rivas, Fernando; Dávalos, Ingrid P.; Olivares, Norma; Dávalos, Nory Omayra; Pérez-Medina, R; Gómez-Partida, Guillermo; Chakraborty, Ranajit

doi:10.1159/000010255

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…An alternative explanation might be that previous miscarriages of women with children who have anencephaly, also had some type of NTD, as the frequency of congenital malformations is greater in miscarriages than in live‐borns 31 . On the other hand, the negative association found between shorter interpregnancy intervals and anencephaly coincides with what has been reported by Rivas et al ., in Mexico, 32 although it differs from the results of Myrianthropoulos and Melnick; 10 Todoroff and Shaw 13 found an association between short interpregnancy intervals and NTDs only when the result of the immediately previous pregnancy was a live birth. We could not evaluate this interaction between the interpregnancy interval and the result of the immediately previous pregnancy due to the small size of the sample.…”

Section: Discussionmentioning

confidence: 59%

Maternal miscarriage history and risk of anencephaly

Blanco-Muñoz¹,

Lacasaña²,

Borja-Aburto

2006

Paediatric Perinatal Epid

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Women with a history of reproductive loss may be at an increased risk of having an unfavourable outcome in subsequent pregnancies. Using data from a matched case-control study based on the record of the Epidemiological Surveillance System of Neural Tube Defects, we evaluated the association between history of maternal reproductive loss and the risk of anencephaly in three Mexican states. Mothers of 157 cases of anencephaly and 151 controls born during the period March 2000 to February 2001, were interviewed about their reproductive history and other additional factors, including socio-economic characteristics, prenatal care, use of tobacco and alcohol, presence of chronic diseases, acute illnesses and fever during the periconceptional period, and consumption of multivitamins and medicines during this period; mothers who reported no prior pregnancies were excluded from the analysis; 58 matched case-control pairs were used for the analysis. After adjusting for potential confounders, women with a history of miscarriage in previous pregnancies had 4.58 times more risk of having a child with anencephaly, than those who did not have this history; OR = 4.58, [95% CI 1.22, 17.23]. Our results suggest that a history of previous miscarriages is a risk indicator for anencephaly in future gestations. This does not necessarily mean that the miscarriage itself is the cause, but that common mechanisms could be involved in the aetiology of both events. Thus, women who have had histories of reproductive losses, especially miscarriages, should be a priority group for the primary and secondary prevention of neural tube defects.

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Section: Discussionmentioning

confidence: 59%

Maternal miscarriage history and risk of anencephaly

Blanco-Muñoz¹,

Lacasaña²,

Borja-Aburto

2006

Paediatric Perinatal Epid

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“…Abortuses previous to [ 6 , 13 , 17 , 22 - 25 ] and subsequent to [ 13 ] NTD offspring have been documented. Although previous abortuses have been suggested to increase the risk of NTD embryogenesis [ 6 , 22 - 25 ], abortuses subsequent to probands suggest that abortus proximity to probands is not a causative but a temporal [ 26 ] relationship.…”

Section: Resultsmentioning

confidence: 99%

“…Spontaneous abortions were defined as non-induced delivery of the fetus at 28 weeks or less after conception. Twenty-eight weeks was chosen because it was a natural break in the distribution of the data and for comparison with prior research [ 13 ]. Stillbirths were defined as delivery of a non-live fetus at 29 weeks or more.…”

Section: Methodsmentioning

confidence: 99%

A reproductive history of mothers with spina bifida offspring-a new look at old issues

Farley

2006

Fluids Barriers CNS

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BackgroundSpina bifida is a disorder of the cerebrospinal fluid system associated with failure of neural tube closure in the fetus. Reproductive history studies of mothers with spina bifida offspring have often been conducted shortly after the affected child's birth. In this study, a large group of community-based mothers were studied after most had completed their families. The aims were to present a more comprehensive reproductive history and to test several hypotheses regarding the nature of spina bifida.MethodsData from 271 mothers was collected by interview 18.3 mean years after the affected child's birth. Data analysis was by χ-square, Fisher exact test and t test with a p value less than 0.05 considered significant.ResultsFemales made up 56.5% of affected offspring (probands) and 53.1% of unaffected offspring. The spina bifida and anencephaly recurrence rate was 4.0%. The twinning rate was 8.6/1000 live births. 24.4% of mothers had a history of spontaneous abortion and the rate varied by pregnancy order from 87 to 185/1000 live births. Duration of pregnancies subsequent to probands was shorter for female than male probands. Mean birth weight of probands with high lesions exceeded those with low lesions. A spontaneous abortion preceded female probands more often than males as compared to live births. Affected males with high lesions conceived by white mothers were at greater risk to be spontaneously aborted. Previous inter-gestational interval for mothers with no history of spontaneous abortion was longer for probands than unaffected offspring but not for mothers with a history of spontaneous abortion.ConclusionOverall, and for every major subgroup of these mothers, more affected and unaffected female than male offspring were born. Differences by gender and lesion level among probands and between probands and unaffected offspring were consistent with an etiology of unknown genetic factors, hormonal and/or immune system factors.

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“…However, the data on the effects of maternal history of prior pregnancies and miscarriages on the risk of isolated congenital defects are sparse. The strongest indication that these factors may be important comes from epidemiological studies of neural tube defects (NTDs) 9–12 . Gravidity also has emerged as a potential risk factor for Down's syndrome that may be independent of maternal age 13–15 .…”

Section: Introductionmentioning

confidence: 99%

“…The strongest indication that these factors may be important comes from epidemiological studies of neural tube defects (NTDs). [9][10][11][12] Gravidity also has emerged as a potential risk factor for Down's syndrome that may be independent of maternal age. [13][14][15] Similar to newborns from multiparous mothers, offspring of mothers with history of prior miscarriages may be at a higher risk of NTDs 16 as well as aneuploidy.…”

Section: Introductionmentioning

confidence: 99%

Maternal reproductive history and the risk of isolated congenital malformations

Materna‐Kiryluk

Więckowska²,

Wiśniewska

et al. 2011

Paediatric Perinatal Epid

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We examined the relationship between maternal reproductive history and the newborn's risk of isolated congenital malformations in a large case-control cohort from the Polish Registry of Congenital Malformations. Congenital malformations were classified into four categories: isolated congenital heart defects (n=1673), isolated cleft palate (n=255), cleft lip with or without cleft palate (n=448) and renal agenesis (n=103). The case groups were compared with a shared group of 2068 controls recruited in the same time period and geographic area. Multivariable logistic regression was used to assess the risk associated with maternal gravidity and of previous miscarriages after accounting for maternal age and other potential risk factors. In unadjusted analyses, maternal gravidity was significantly associated with increased risk of all four classes of congenital malformations. After adjustment, a significant association persisted for congenital heart defects [odds ratio (OR)=1.22, [95% confidence interval (CI) 1.09, 1.36], P=0.0007] and cleft lip with or without cleft palate (OR=1.21, [95% CI 1.09, 1.36], P=0.0005). A similar trend existed for isolated cleft palate (OR=1.18, [95% CI 1.02, 1.37], P=0.03). There was no appreciable increase in the risk of congenital malformations associated with a maternal history of miscarriages, but a trend for a protective effect on the occurrence of cleft lip with or without cleft palate was observed (OR=0.72, [95% CI 0.52, 0.99], P=0.045). Based on our data, maternal gravidity represents a significant risk factor for congenital heart defects and cleft lip with or without cleft palate in the newborn infant. Our data do not support an increase in risk because of past history of miscarriages.

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Reproductive History in Mothers of Children with Neural Tube Defects

Cited by 7 publications

References 18 publications

Maternal miscarriage history and risk of anencephaly

Maternal miscarriage history and risk of anencephaly

A reproductive history of mothers with spina bifida offspring-a new look at old issues

Maternal reproductive history and the risk of isolated congenital malformations

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