Reproductive impairment in a fish inhabiting a contaminated coastal environment off Southern California

Hose, Jo Ellen; Cross, Jeffrey N.; Smith, Steven G.; Diehl, Dario W.

doi:10.1016/0269-7491(89)90006-7

Cited by 77 publications

(39 citation statements)

References 24 publications

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“…The observed effects on gonadal development and histopathology in the present study are consistent with some previous studies of effects of DDT exposure on fishes, yet inconsistent with other studies. Female white croakers (Genyonemus lineatus) collected from San Pedro Bay, California, with body burdens of ≥ 3.8 ppm ΣDDT (total of all isomers of DDT and its breakdown products) could not be induced to spawn and exhibited only earlystage oocytes, of which high numbers were atretic relative to reference fish (Hose et al 1989). In contrast to our results, Metcalfe et al (2000) reported advanced oogenesis in female medaka developed from eggs with o,p´-DDT concentrations of approximately 80-102 ng/egg, although both reference and treated groups began producing viable eggs at the same time.…”

Section: Discussionmentioning

confidence: 99%

“…However, like o,p´-DDT, o,p´-DDE is believed to work through the ER and to have a similar ER agonist potency (Donohoe and Curtis 1996), and exposure to o,p´-DDE has been associated with decreased fecundity and fertility and increased early oocyte atresia (Hose et al 1989). Recently, Wells and Van Der Kraak (2000) showed that o,p´-DDE and o,p´-DDT will also bind to the androgen receptor in goldfish (Carassius auratus) but not rainbow trout (Oncorhynchus mykiss) testes at approximately half the affinity of p,p´-DDE.…”

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confidence: 99%

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In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Papoulias

Villalobos

Meadows

et al. 2003

Environ Health Perspect

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Despite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p -DDT, o,p -DDE is estrogenic and is believed to exert its effects through binding to the estrogen receptor. The limited toxicologic data for o,p -DDE suggest that it decreases fecundity and fertility of fishes. We conducted an egg injection study using the d-rR strain of medaka and environmentally relevant concentrations of o,p -DDE to examine its effects on sexual differentiation and development. The gonads of exposed fish showed no evidence of sex reversal or intersex. However, other gonad abnormalities occurred in exposed individuals. Females exhibited few vitellogenic oocytes and increased atresia. Male testes appeared morphologically normal but were very small. Gonadosomatic index values for both sexes were lower for exposed fish. Our observations of abnormal female and very small male gonads after in ovo o,p -DDE exposure may be indicative of effects on early endocrine processes important for normal ovarian and testicular development.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Papoulias

Villalobos

Meadows

et al. 2003

Environ Health Perspect

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“…Previous studies in coastal areas of the Southern California Bight (SCB), including areas affected by sewage discharges, have shown that white croaker were susceptible to effects from xenobiotic contaminants. Adverse responses to chemical contaminants were manifested by elevated concentrations of organochlorines in muscle tissues (e.g., Gossett et al 1983), reproductive impairment (Hose et al 1989), and toxicopathic liver lesions (Malins et al 1987;Myers et al 1994;Stehr et al 1998). Thus, white croaker represents a potentially important sentinel species for evaluating effects from wastewater exposures.…”

Section: Introductionmentioning

confidence: 99%

Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Basmadjian

Perkins

Phillips

et al. 2007

Environ Monit Assess

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The prevalence of toxicopathic liver lesions in demersal fish on the San Pedro Shelf, California was determined for a 15-year period (1988-2003). Fish livers were sampled at fixed locations as part of the Orange County Sanitation Districts (OCSD) ocean monitoring program. Histopathological examination of selected fish liver tissues was studied to determine whether the wastewater discharge had affected fish health. The prevalence of toxicopathic lesion classes neoplasms (NEO), preneoplastic foci of cellular alteration (FCA), and hydropic vacuolation (HYDVAC) varied among species and locations. For all species sampled, severe lesions occurred in 6.2% of the fish examined (n=7,694). HYDVAC (4.1%) was the most common toxicopathic lesion type followed by FCA (1.4%) and NEO (0.7%). HYDVAC occurred only in white croaker (Genyonemus lineatus), accounting for 84.8% of the toxicopathic lesions for this species. Prevalence of HYDVAC, NEO, and FCA in white croaker was 15.2, 2.0, and 0.7%, respectively. The prevalence of HYDVAC and NEO in white croaker increased with age and size but there was no sexual difference. A linear regression model was used for hypothesis testing to account for significant differences in fish size (and age for croakers) at the different sampling locations. This analysis showed that for HYDVAC there was no spatial or location effect for lesion rate or size/age of onset. For NEO, the model predicted that white croaker near the wastewater outfall may acquire these lesions at a smaller size/younger age, and at a higher rate, than at other sites. However, this result may be biased due to the unequal size frequency distributions and the low prevalence of NEO in white croaker at the different sampling sites. Bigmouth sole (Hippoglossina stomata) had a prevalence of FCA and NEO of 1.3 and 0.35%, respectively, but the prevalence and distribution of lesions was too few for statistical testing. There was no sexual difference for lesion prevalence in hornyhead turbot (Pleuronichthys verticalis) and the prevalence of FCA and NEO was 3.4 and 0.37%, respectively. FCA prevalence increased with size in hornyhead turbot and there were no significant spatial differences for lesion rates and fish size at lesion onset. Overall, consistent spatial differences for lesion prevalence were not demonstrated and highlight the analytical difficulties of detecting a possible point source impact when the effect is rare, correlated with the size/age structure of the population, and may be caused by exposure to unknown multiple sources. Thus, the usefulness of liver histopathology as a point-source monitoring tool is best applied to where the spatial scale of impact generally exceeds the home range of the target species.

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“…Contaminants can enter the food chain and some can subsequently bioaccumulate in wildlife. A few of these chemicals have been associated with reproductive injury in wildlife (2)(3)(4)(5)(6)(7). In December 1993, a group of North American wildlife biologists convened to critically assess evidence of specific instances where these contaminants were reported to produce deleterious effects in wildlife populations through interference with reproduction or embryonic development.…”

Section: Introductionmentioning

confidence: 99%

Defining the Role of Pollutants in the Disruption of Reproduction in Wildlife

Hose¹,

Guillette²

1995

Environmental Health Perspectives

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Although chemical exposure has been associated with reduced reproduction in certain North American fish, reptiles, and mammals, definitive causeand-effect data are lacking in many instances. Because the increasing use and global transport of industrial chemicals pose significant risk to successful reproduction, methods should be developed that can define the geographic extent and magnitude of injury and risk to wildlife. Because industrial chemicals are articles of commerce, information about injury to wildlife has been contentious and too often ineffective in changing societal behavior. The following strategies are advocated for inferring causal relationships. First, a balanced and comprehensive assessment of the data is necessary to determine the geographic extent of exposure and reproductive effects associated with environmental pollution. Initial efforts to document reproductive injury should focus on specific ecosystems in which detrimental effects have been observed, but lack sufficient causal data. Model systems (including experimental mesocosms or field ecosystems) should be identified or designed that can adequately test multigenerational reproductive effects. Mechanistic data from supportive laboratory studies on reproductive toxicity, quantitative structure-activity relationships, and bioaccumitlation can be used to predict effects of related pollutants and to determine risk. Such information is essential to prevent future injury to wildlife and to prioritize the numerous remediation decisions facing our society. -Environ Health Perspect 1 03(Suppl 4): 87-91 (1995)

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Reproductive impairment in a fish inhabiting a contaminated coastal environment off Southern California

Cited by 77 publications

References 24 publications

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Defining the Role of Pollutants in the Disruption of Reproduction in Wildlife

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