Reproductive outcome after anesthesia and operation during pregnancy: A Registry study of 5405 cases

Mazze, Richard I.; Källén, Bëngt

doi:10.1016/0002-9378(89)90659-5

Cited by 492 publications

(126 citation statements)

References 18 publications

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“…Maternal abdominal disease and its operative treatment are associated with a fetal loss rate of 2–24%, according to recent literature [1, 2, 3]. Additional risks to the fetus include teratogenicity during the first trimester and preterm labor and delivery during the second and third trimesters.…”

Section: Introductionmentioning

confidence: 88%

“…No fetal loss occurred during any trimester. Fetal loss of 2–24% has been reported [1, 2, 3], with the lower end of this range representing more recent trends. Similar to another report [3], we found no identifiable neonatal birth defects.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal loss of 2–24% has been reported [1, 2, 3], with the lower end of this range representing more recent trends. Similar to another report [3], we found no identifiable neonatal birth defects. Five percent of the patients delivered prematurely in this series, while other authors have reported preterm delivery ranging from 2–22% [1, 3].…”

Section: Discussionmentioning

confidence: 99%

“…The scope of the problem is significant, as approximately 13–44 out of every 10,000 women require nonobstetric abdominal surgery during pregnancy [1, 2, 3]. Appendectomy, cholecystectomy and adnexal procedures are the most commonly performed operations [1].…”

Section: Introductionmentioning

confidence: 99%

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Safety and Timing of Nonobstetric Abdominal Surgery in Pregnancy

et al. 2001

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Background/Aims: Abdominal disorders occurring during pregnancy pose special difficulties in diagnosis and management to the obstetrician and surgeon. The advisability of nonobstetric abdominal surgery during pregnancy is uncertain. Our objective was to evaluate the safety and timing of abdominal surgery during pregnancy. Methods: We retrospectively reviewed 77 consecutive gravid patients undergoing nonobstetric abdominal surgery from 1989 to 1996 at an urban academic medical center and a large affiliated community teaching hospital. Medical records were evaluated for clinical presentation, perioperative management, preterm labor, and maternal and fetal morbidity and mortality. Results: The rate of nonobstetric abdominal surgery during pregnancy was 1 in every 527 births. Among the 77 patients, the indications for surgery were adnexal mass (42%), acute appendicitis (21%), gallstone disease (17%) and other (21%). There was no maternal or fetal loss or identifiable neonatal birth defect. Preterm labor occurred in 26% of the second-trimester patients and 82% of the third-trimester patients. Preterm labor was most common in patients with appendicitis and after adnexal surgery. Preterm delivery occurred in 16% of the patients, but appeared to be directly related to the abdominal surgery in only 5%. Conclusion: Surgery during the first or second trimester is not associated with significant preterm labor, fetal loss or risk of teratogenicity. Surgery during the third trimester is associated with preterm labor, but not fetal loss.

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Section: Introductionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety and Timing of Nonobstetric Abdominal Surgery in Pregnancy

et al. 2001

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“…Patients with a lung tumor larger than 2.0-cm or with enlarged mediastinal lymph nodes (>1.0 cm) usually also undergo a mediastinoscopy with lymph node sampling. This requires general anesthesia which in two large case control studies of 2,565 and 5,405 pregnant women undergoing surgical procedures did not result in an increase in congenital anomalies [36, 37]. However, the former study did find an increased risk of spontaneous abortions in patients receiving general anesthesia (RR = 1.58; 95% CI = 1.19–2.09) while the latter study found an increase in low-birth-weight (<2,500 g) infants (RR = 2.0; 95% CI = 1.8–2.2) and premature births (gestational age <37 weeks; 7.47 vs. 5.13% in controls; p < 0.001) in patients undergoing an operation while pregnant (any trimester).…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy for a Patient with Advanced Non-Small-Cell Lung Cancer during Pregnancy: A Case Report and a Review of Chemotherapy Treatment during Pregnancy

et al. 2001

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Background: Lung cancer is the most common cause of cancer death in women in the USA. Lung cancer arising during pregnancy is rare and has been reported only 15 times since the 1950s. However, the use of chemotherapy for lung cancer during pregnancy has not previously been reported. Methods: The history, treatment and outcome of a patient with stage IV non-small-cell lung carcinoma (NSCLC) diagnosed during pregnancy is presented. Previous published reports on lung cancer were retrieved by a literature search of Medline and Cancerlit. Results: A 31-year-old woman was diagnosed as having stage IV NSCLC with bilateral pulmonary involvement when 26 weeks pregnant. Her shortness of breath progressed to dyspnea at rest on 100% inspired oxygen. Therefore, she was treated with systemic chemotherapy using cisplatin and vinorelbine. Despite this treatment, her oxygenation declined further over the next 4 days and thus the baby was delivered via cesarean section after 27 weeks of gestation. Four cycles of vinorelbine and cisplatin have now been administered. Following this treatment, the patient has experienced a significant clinical improvement and no longer requires supplemental oxygen. No chemotherapy-related adverse effects have been noted in the baby. In the 15 previously reported patients with concurrent lung cancer and pregnancy, chemotherapy administration during pregnancy has not been described. Conclusions: Treatment of lung cancer with chemotherapy during pregnancy should be considered on an individual basis with regard to the stage of the cancer and the maturity of the fetus. To our knowledge, the case presented here is the first report of a woman receiving chemotherapy for lung cancer while pregnant.

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Breast Cancer in Pregnancy

Woo

Yu²,

Hurd³

2003

Arch Surg

254

164

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Breast cancer in pregnancy will increase as more women postpone childbearing until later in life. Objective: To review the literature on diagnosis, staging, treatment, and prognosis. Design and Methods: Articles were obtained from MEDLINE (1966-present) using the keywords breast, cancer, carcinoma, and pregnancy. Additional articles were sought using the references of those obtained. A total of 171 articles were found, 125 in English. More than 100 were reviewed, including 7 prospective and 40 retrospective studies, 6 case reports, and at least 47 review articles on various aspects of pregnancy and cancer. Data extraction was performed by 1 reviewer. Results: Diagnostic delays are shorter than in the past but remain common. Mammography has a high falsenegative rate during pregnancy. Biopsy or needle aspi

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Reproductive outcome after anesthesia and operation during pregnancy: A Registry study of 5405 cases

Cited by 492 publications

References 18 publications

Safety and Timing of Nonobstetric Abdominal Surgery in Pregnancy

Safety and Timing of Nonobstetric Abdominal Surgery in Pregnancy

Chemotherapy for a Patient with Advanced Non-Small-Cell Lung Cancer during Pregnancy: A Case Report and a Review of Chemotherapy Treatment during Pregnancy

Breast Cancer in Pregnancy

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